A5056480326- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Organometallic Complex Synthesis and Catalysis
- Crystallography and molecular interactions
- Synthesis and Catalytic Reactions
- Mass Spectrometry Techniques and Applications
- Asymmetric Hydrogenation and Catalysis
- Carbon dioxide utilization in catalysis
- Catalytic Alkyne Reactions
- Advanced Photocatalysis Techniques
- Synthetic Organic Chemistry Methods
- Advanced oxidation water treatment
- Photosynthetic Processes and Mechanisms
- Electrocatalysts for Energy Conversion
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- Advanced Proteomics Techniques and Applications
- Insect and Pesticide Research
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Automated Road and Building Extraction
- Quinazolinone synthesis and applications
Liaocheng University
2025
Shandong University
2022-2024
Anhui University of Science and Technology
2024
Beijing Jiaotong University
2024
Anhui Science and Technology University
2024
Wuhan University of Technology
2023
Shenyang University of Chemical Technology
2023
Megvii (China)
2023
Northeastern University
2023
Ningbo Institute of Industrial Technology
2022
We report realization of the first enantioselective Cope-type hydroamination oximes for asymmetric nitrone synthesis. The ligand promoted cyclopropene "hydronitronylation" process employs a Cu-based catalytic system and readily available starting materials, operates under mild conditions displays broad scope exceptionally high enantio- diastereocontrol. Preliminary mechanistic studies corroborate CuI-catalytic profile featuring an olefin metalla-retro-Cope aminocupration as key C-N bond...
The edge sites of MoS2 are catalytically active for hydrogen evolution reactions (HER). However, pristine usually contain only intrinsic atoms or defects, limiting the tuning on-site species adsorption and desorption, critical steps HER. In addition, number on edges is small compared to that electrochemically inert in bulk. Thus, it desirable develop a scalable technique creating large highly HER-active sites. Here, plasma etching strategy developed electrodes with controllable enable...
Keyhole imagery documented global surface from 1960 to 1980s and has contributed earth change research, while evaluation of its' coverage spatial heterogeneity is rare. In this work the boundary vectors with attributes all freely images within China were obtained USGS website automatically investigate characteristics using ArcPy library in Python. Images categorized into meter-level (C1), five-meter-level (C2), ten-meter-level (C3). The resolution distribution at national provincial levels...
Soil sickness is a critical problem for eggplant (Solanum melongena L.) under continuous cropping that affects sustainable production. Relay intercropping significant technique on promoting soil quality, improving eco-environment, and raising output. Field experiments were conducted from September 2010 to November 2012 in northwest China determine the effects of relay with garlic (Allium sativum enzyme activities, available nutrient contents, pH value plastic tunnel. Three treatments...
The use of functional-group-tolerant organoboron in lieu basic organometallic reagents base-metal-catalyzed cyclopropene carbometalation opens three-component cyclopropane synthesis, as exemplified by the modular assembly highly medicinally relevant 2-arylcyclopropylamine (ACPA) framework via stereoselective carboamination. enantioselective version has been realized to afford enantioenriched ACPAs with up all three cyclopropyl carbons stererogenic centers one operation, representing first...
Programmed cell death-1 (PD-1), an antigen co-receptor on surfaces, is one of the conspicuous immune checkpoints. Nivolumab, a monoclonal antibody therapeutic approved by FDA, binds to PD-1 and efficiently blocks its pathways. In this study, integrated approach was developed map epitope/paratope PD-1/nivolumab. The includes hydrogen-deuterium exchange mass spectrometry (HDX-MS) followed electron-transfer dissociation (ETD), chemical cross-linking, molecular docking. HDX-ETD offers some...
We describe an integrated approach of using hydrogen–deuterium exchange mass spectrometry (HDX-MS), chemical cross-linking (XL-MS), and molecular docking to characterize the binding interface predict three-dimensional quaternary structure a protein–protein complex in solution. Interleukin 7 (IL-7) its α-receptor, IL-7Rα, serving as essential mediators immune system, are model system. HDX kinetics reports widespread protection on IL-7Rα but shows no differential evidence binding-induced or...
Gamma-aminobutyric acid (GABA) has been reported to accumulate in plants when subjected salt stress, and GABA-transaminase (GABA-T) is the main GABA-degrading enzyme GABA shunt pathway. So far, tolerance mechanism of GABA-T gene behind metabolism remains unclear. In this study, cDNA (designated MuGABA-T) was cloned from mulberry, our data showed that MuGABA-T protein shares some conserved characteristics with its homologs several plant species. constitutively expressed at different levels...
Cyanobacterial phycobilisomes (PBSs) are photosynthetic antenna complexes that harvest light energy and supply it to two reaction centers (RCs) where photochemistry starts. PBSs can be classified into types, depending on the presence of allophycocyanin (APC): CpcG-PBS CpcL-PBS. Because accurate protein composition CpcL-PBS remains unclear, we describe here its isolation characterization from cyanobacterium
Cyanobacterial light-harvesting complex features efficient energy capture, transmission, and regulation to reaction centers.
Colorless polyimides with high glass transition temperatures and excellent optical transparency were developed from norbornyl bis-benzocyclobutene-containing diamines, the structure–property relationship of these was established.
A mild and environmentally electrochemical method for the synthesis of quinazolines quinazolinones has been developed through anodic oxidation decarboxylative α-oxocarboxylic acids. The present reaction was efficiently conducted by using simple cheap NH4I as N-source electrolyte in an undivided cell. desired products, quinazolinones, were isolated high yield under chemical oxidant free conditions.
We found that a newly developed method named LITPOMS (ligand titration, fast photochemical oxidation of proteins and mass spectrometry) can characterize section-by-section protein the conformational changes induced by metal-ion binding. Peptide-level applied to Ca2+ binding calmodulin reveals order site-specific affinity, providing new insights on behavior upon Ca2+. established EF hand-4 (EF-4) binds calcium first, followed EF-3, EF-2, EF-1 determined four affinity constants modeling...
Fast photochemical oxidation of protein (FPOP) has become an important mass spectrometry-based footprinting approach. Although the hydroxyl radical (•OH) generated by photolysis hydrogen peroxide (H2O2) is most commonly used, pathways for its reaction with amino-acid side chains remain unclear. Here, we report a systematic study •OH oxidative modification 13 amino acid residues using 18O isotopic labeling. The results differentiate three classes on basis their oxygen uptake preference toward...
The Pd<sup>0</sup>-catalyzed carboannulation of γ,δ-alkenyl oximes with organohalides offers catalyst-controlled access to 5-membered cyclic nitrones or 6-membered oxime ethers.