A5036910275- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Flame retardant materials and properties
- Surface Modification and Superhydrophobicity
- Peptidase Inhibition and Analysis
- Advanced Photocatalysis Techniques
- Carbohydrate Chemistry and Synthesis
- Electrodeposition and Electroless Coatings
- Polymer Nanocomposites and Properties
- Copper Interconnects and Reliability
- Pluripotent Stem Cells Research
- Electrohydrodynamics and Fluid Dynamics
- Analytical Chemistry and Chromatography
- Microbial Natural Products and Biosynthesis
- Aerogels and thermal insulation
- Anodic Oxide Films and Nanostructures
- Silicone and Siloxane Chemistry
- Bioactive natural compounds
- Monoclonal and Polyclonal Antibodies Research
- Nanofabrication and Lithography Techniques
- Embedded Systems and FPGA Applications
- Biological and pharmacological studies of plants
- Photopolymerization techniques and applications
- Hydrogen Storage and Materials
- Copper-based nanomaterials and applications
Shanghai University of Electric Power
2023-2024
Shanghai Stock Exchange
2024
Changchun University of Technology
2023-2024
Central South University
2024
Shanxi Medical University
2023-2024
Zhejiang Medicine (China)
2023
Southwest University
2021
Northwestern Polytechnical University
2020-2021
Zhejiang University of Technology
2021
China XD Group (China)
2020
A series of novel tri(4-benzoylphenyl) phosphate (TBP) derivatives with unique precipitation-inducing properties were synthesized and used as C-terminal protecting groups amino acids recyclable supports in peptide synthesis.
Plecanatide is an oral guanylate cyclase-C agonist for the treatment of gastrointestinal disorders. The large-scale supply plecanatide restrained primarily by its industrial manufacture. Herein we developed diphenylphosphinyloxyl diphenyl ketone (DDK) derivatives as greener supports with unique precipitation-inducing properties to aid liquid-phase total synthesis without use chromatography. could be obtained in high yield, and ultimately sheared DDK derivative residue directly recycled or...
To seek the novel application of organophosphorus compounds, designed tri(4-formylphenyl) phosphonate (TFP) derivatives were successfully synthesized herein, which used as C-terminal protecting groups amino acid or greener triple-equivalent supports in liquid-phase peptide synthesis (LPPS). Through support-aided precipitation effect TFP derivatives, intermediates during separated and collected via rapid facile filtration without chromatographic purification. Furthermore, derivative support...
Tri(4′-diphenylphosphonyloxylbenzoyl phenyl)phosphate (TDPBP) derivatives were developed as greener supports to aid high-efficiency liquid-phase peptide synthesis without the need for unrecyclable resin and tedious chromatographic separation.
Comprehensive Summary TAG‐assisted peptide synthesis technology enables optimal conservation of Fmoc amino acid raw materials and chemical solvents while eliminating the need for intricate chromatographic purification processes. This work presents a 4,4'‐diphenylphosphonoxy diphenylcarbinol tag‐mediated liquid‐phase approach preparing side‐to‐tail cyclopeptides macolacin which has strong activity against gram‐negative bacteria, its 15 analogues containing four N ‐methylation modified...
Traditionally, many coatings were merely concentrated on settling the inherent fire protection problem of steel structures, while surface contamination and corrosion susceptibility should also be considered. Concurrently addressing these problems in fireproof efficiency multifunctionality has become an issue great significance further expanding application value industrial daily scenarios. Based this condition, ecofriendly, graphene-based, superhydrophobic with multifunctional integration...
For settling the recycling problem of waste polyurethane sponges (PU) and environment pollution oil spills simultaneously, this work exploited multifunctional superhydrophobic PU materials via dip-coating method, which were prepared by anchoring modified Fe3O4 expandable graphite (EG) on under adhesion effect polydimethylsiloxane (PDMS). The water contact angle sliding as-prepared reached 154.1 ± 1.6 8°, respectively. Most importantly, endowed with multipath treatment ability, consisted...
Tylosin is a 16-membered macrolide antibiotic widely used in veterinary medicine to control infections caused by Gram-positive pathogens and mycoplasmas. To improve the fermentation titer of tylosin hyperproducing Streptomyces xinghaiensis strain TL01, we sequenced its whole genome identified biosynthetic gene cluster therein. Overexpression efflux tlrC, cluster-situated S-adenosyl methionine (SAM) synthetase metKcs, SAM genes adoKcs-metFcs, or pathway-specific activator tylR enhanced...
Abstract Previous studies revealed that early life stress is associated with romantic relationship quality in the history perspective Western nations. The current study examined relationships between strategy, harshness/parents' parenting style, and quality, as well strategy a mediator association style China. A total of 263 individuals participated questionnaire survey. Results direct effects quality. Both harshness parents' have indirect on through → communication/commitment paths. Thus,...
4,4′-bis(diphenylphosphinyloxyl) diphenyl ketoxime and 4-diphenyl phospholoxy benzyl alcohol were designed prepared as supports for peptide synthesis. The total synthesis of cyclic peptides in a resin-free manner was successfully demonstrated.
A series of phosphonate or aliphatic-based tags were developed to achieve sustainable peptide synthesis, resulting in over a 10-fold reduction solvent usage compared SPPS.