A5035509953- Chemical Synthesis and Analysis
- Advanced Photocatalysis Techniques
- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- Carbohydrate Chemistry and Synthesis
- Click Chemistry and Applications
- Folate and B Vitamins Research
- Copper-based nanomaterials and applications
- TiO2 Photocatalysis and Solar Cells
- Polysaccharides and Plant Cell Walls
- Phytochemicals and Antioxidant Activities
- Protein Hydrolysis and Bioactive Peptides
- Nanopore and Nanochannel Transport Studies
- Gas Sensing Nanomaterials and Sensors
- Marine Sponges and Natural Products
- X-ray Diffraction in Crystallography
- Photoreceptor and optogenetics research
- Advanced Nanomaterials in Catalysis
- Crystallization and Solubility Studies
- Photochromic and Fluorescence Chemistry
- Electrocatalysts for Energy Conversion
- Natural product bioactivities and synthesis
- Radical Photochemical Reactions
- Advanced biosensing and bioanalysis techniques
- Diatoms and Algae Research
Northwestern Polytechnical University
2015-2025
Ministry of Industry and Information Technology
2022-2024
China XD Group (China)
2016-2020
Scripps Research Institute
2019
The Ohio State University
2005
University of Hong Kong
2003-2004
Hong Kong University of Science and Technology
2003-2004
Huazhong University of Science and Technology
2001-2002
Hubei Polytechnic University
2002
C–N cross-coupling is one of the most valuable and widespread transformations in organic synthesis. Largely dominated by Pd- Cu-based catalytic systems, it has proven to be a staple transformation for those both academia industry. The current study presents development mechanistic understanding an electrochemically driven, Ni-catalyzed method achieving this reaction high strategic importance. Through series electrochemical, computational, kinetic, empirical experiments, key features have...
It goes both ways: A thiol-reactive cross-linker based on a bridged azobenzene derivative permits photoreversible control of peptide conformation irradiation with violet (407 nm) and green (500–550 light (see picture) through isomerization the cross-linker. The large separation absorbance bands cis (yellow) trans (red) isomers enables complete bidirectional photoswitching. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed,...
Herein, we present a unified strategy for the total synthesis of benzenoid and troponoid Cephalotaxus diterpenoids, specifically cephanolides A B (benzenoids) harringtonolide cephinoid H (troponoids), in 13 to 19 longest linear steps. This relies on palladium-catalyzed Csp2–Csp3 cross–coupling followed by an intramolecular doubly electron-deficient Diels–Alder reaction establish core skeleton complete benzenoids. late-stage regioselective phenol-to-tropone ring expansion was developed...
The fruit of mulberry (Morus alba L., Moraceae) has been used as medicinal food in China for a long history. pigment from the extract is kind natural colourant processing and potential medical commercial values. This study focuses on analysis characterisation anthocyanins pigment. fresh fruits were extracted with solvent 95% alcohol/0.1% HC l (1:1, ratio) at room temperature 4 h dark. After isolation using C-18 column, was identified UV-Visible Spectroscopy, HPLC-PAD, LC-MS, 1HNMR. results...
The fascinating benzenoid and troponoid Cephalotaxus diterpenoids are highly related biosynthetically, both of which popular targets for total synthesis. Herein, we describe a unified strategy the concise synthesis cephanolide A harringtonolide in 14 16 steps respectively. Palladium catalyzed Csp2-Csp3 cross-coupling followed by doubly electron-deficient intramolecular Diels-Alder reaction secure rapid construction carbon framework. Late-stage benzenoid-to-troponoid ring expansion was...
Es geht in beide Richtungen: Ein Thiol-reaktiver Netzbildner, der auf einem verbrückten Azobenzolderivat basiert, ermöglicht die photoreversible Steuerung Peptidkonformation durch Bestrahlung mit violettem (407 nm) und grünem Licht (500–550 nm; siehe Bild). Der große Abstand Absorptionsbanden cis- (gelb) trans-Isomere (rot) ein vollständiges bidirektionales Photoschalten.
Artificial solid-state nanochannels have garnered considerable attention as promising nanofluidic tools for ion/molecular detection, DNA sequencing, and biomimicry. Recently, devices emerged cost-effective detection heavy metal ions by modifying stimuli-responsive materials. In this work, high-purity glycyl-l-histidyl-l-lysine (GHK) peptide is synthesized using 7-diphenylphosphonooxycoumarin-4-methanol (DPCM) a protecting group auxiliary carrier homogeneous synthesis of photocleavable...
A series of novel tri(4-benzoylphenyl) phosphate (TBP) derivatives with unique precipitation-inducing properties were synthesized and used as C-terminal protecting groups amino acids recyclable supports in peptide synthesis.
Abstract Atherosclerosis is one of the leading causes morbidity and mortality, mainly due to immune response triggered by recruitment monocytes/macrophages in artery wall. Accumulating evidence have shown that matrix stiffness oxidized low‐density lipoproteins (ox‐LDL) play important roles atherosclerosis through modulating cellular behaviors. However, whether there a synergistic effect for ox‐LDL on macrophages behavior has not been explored yet. In this study, we developed model system...
Plecanatide is an oral guanylate cyclase-C agonist for the treatment of gastrointestinal disorders. The large-scale supply plecanatide restrained primarily by its industrial manufacture. Herein we developed diphenylphosphinyloxyl diphenyl ketone (DDK) derivatives as greener supports with unique precipitation-inducing properties to aid liquid-phase total synthesis without use chromatography. could be obtained in high yield, and ultimately sheared DDK derivative residue directly recycled or...
Nickel stands out as one of the prevalent heavy metal ionic pollutants found in water. It is urgent to devise a simple, efficient, budget-friendly, highly-selective and proficient method for detecting Ni(II). This work reports an approach design nanofluidic diode ultrasensitive label-free detection nickel ions based on layer-by-layer assembly polyarginine (PA) polyglutamic acid (γ-PGA) inner surface asymmetric nanochannels. We can tune adsorption/desorption characteristics nanochannels Ni2+...
Using an alanine-scanning method, we have found that the antibacterial and hemolytic activities of amphipathic cyclic decapeptide antibiotic tyrocidine A depend on different structural components. Single substitution glutamine-6 natural product with a cationic amino acid results in therapeutic index enhancement up to 140-fold. Successful dissociation two intimately associated properties should enable discovery novel analogues both high bacterial selectivity potency counter microbial resistance.