A5010387410- Genetics, Aging, and Longevity in Model Organisms
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Mitochondrial Function and Pathology
- Biochemical Analysis and Sensing Techniques
- Pharmaceutical studies and practices
- Insect Resistance and Genetics
- Mental Health Research Topics
- Cholinesterase and Neurodegenerative Diseases
- Crystallization and Solubility Studies
- Treatment of Major Depression
- Microbial Natural Products and Biosynthesis
- X-ray Diffraction in Crystallography
- Neurobiology and Insect Physiology Research
- Computational Drug Discovery Methods
- RNA Interference and Gene Delivery
- Chemical Synthesis and Analysis
- Adipose Tissue and Metabolism
- Click Chemistry and Applications
- RNA Research and Splicing
- Neuropeptides and Animal Physiology
- Ubiquitin and proteasome pathways
- Psychedelics and Drug Studies
- DNA and Nucleic Acid Chemistry
Scripps Research Institute
2017-2025
Scripps Institution of Oceanography
2024
Scripps (United States)
2024
C–N cross-coupling is one of the most valuable and widespread transformations in organic synthesis. Largely dominated by Pd- Cu-based catalytic systems, it has proven to be a staple transformation for those both academia industry. The current study presents development mechanistic understanding an electrochemically driven, Ni-catalyzed method achieving this reaction high strategic importance. Through series electrochemical, computational, kinetic, empirical experiments, key features have...
Tetrachloro-N-hydroxyphthalimide tetramethyluronium hexafluorophosphate (CITU) is disclosed as a convenient and economical reagent for both acylation decarboxylative cross-coupling chemistries. Within the former set of reactions, CITU displays reactivity similar to that common coupling reagents, but with increased safety reduced cost. latter, yields, more rapid conversion, simplified procedure are possible across range reported transformations.
ABSTRACT Analysis of existing lifespan‐extending geroprotective compounds suggested that polypharmacological are the most effective geroprotectors, specifically those bind multiple biogenic amine receptors. To test this hypothesis, we used graph neural networks to predict geroprotectors and evaluated them in Caenorhabditis elegans . Over 70% selected extended lifespan, with effect sizes top 5% compared all recorded DrugAge database. Thus, our study reveals rationally designing enables design...
Recent work has revealed an increasingly important role for mRNA translation in maintaining proteostasis. Here, we use chemical inhibitors targeting discrete steps of to compare how lowering the concentration all or only initiation-dependent proteins rescues Caenorhabditis elegans from proteotoxic stress. We systematically challenge proteostasis and show that pharmacologically inhibiting initiation elongation elicits a distinct protective profile. Inhibiting protects heat proteasome...
C–N cross-coupling is one of the most valuable and widespread transformations in organic synthesis. Largely dominated by Pd- Cu-based catalytic systems, it has proven to be a staple transformation for those both academia industry. The current study presents development mechanistic understanding an electrochemically driven, Ni-catalyzed method achieving this reaction high strategic importance. Through series electrochemical, computational, kinetic, empirical experiments key features have been...
<div> <p>C–N cross-coupling is one of the most valuable and widespread transformations in organic synthesis. Largely dominated by Pd- Cu-based catalytic systems, it has proven to be a staple transformation for those both academia industry. The current study presents development mechanistic understanding an electrochemically driven, Ni-catalyzed method achieving this reaction high strategic importance. Through series electrochemical, computational, kinetic, empirical experiments...
Analysis of lifespan-extending compounds suggested the most effective geroprotectors target multiple biogenic amine receptors. To test this hypothesis, we used graph neural networks to predict such polypharmacological and evaluated them in
Achiral N9-benzylguanine derivatives with alkene moieties attached to the benzyl group were synthesized intent of targeting a covalently linked unimolecular quadruplex using olefin cross-metathesis. Three N9-(3,5-bis(alkenyloxy)benzyl)-guanine and shown form stable G-quartet structures in presence central cation. Upon addition K+, guanine derivative, N9-(3,5-Bis(pent-4-en-1-yloxy)benzyl)-guanine, self-assembled into discrete [G]12-dodecamer structure. Keywords: Guanine, benzylguanine, DNA,...
Several naturally occurring molecules exhibit unique potential in treating certain elements of psychiatric illnesses and are being actively pursued therapeutic development. Among these termed entheogens, a preferred name for plant-derived compounds that alter human consciousness religious or spiritual purposes, which especially important to various Indigenous groups, their use within cultures precedes the contemporary medicalized use. Here, we acknowledge some entheogens were included DARK...
Abstract Recent work has revealed an increasingly important role for mRNA translation in maintaining proteostasis. Inhibiting protects from various proteostatic insults, including heat, expression of aggregation-prone proteins, or aging. However, multiple studies have come to differing conclusions about the mechanisms underlying protective effects inhibition. Here, we systematically lower either by pharmacologically inhibiting initiation elongation and show that each step activates distinct...