A5091838242- Gynecological conditions and treatments
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Intestinal and Peritoneal Adhesions
- Ectopic Pregnancy Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Reproductive tract infections research
- Reproductive System and Pregnancy
- Cervical Cancer and HPV Research
- Maternal and fetal healthcare
- Cancer-related molecular mechanisms research
- Maternal and Perinatal Health Interventions
- RNA modifications and cancer
- Gut microbiota and health
- Pelvic floor disorders treatments
- Ovarian cancer diagnosis and treatment
- Cancer-related gene regulation
- RNA Research and Splicing
- Diet and metabolism studies
- Gestational Trophoblastic Disease Studies
- Ovarian function and disorders
- Minimally Invasive Surgical Techniques
- Tryptophan and brain disorders
- Surgical Sutures and Adhesives
- Reproductive Physiology in Livestock
Central South University
2014-2024
Third Xiangya Hospital
2014-2024
Second Xiangya Hospital of Central South University
2022
First Affiliated Hospital of GuangXi Medical University
2021
Guangxi Medical University
2021
Xiangya Hospital Central South University
1970-2021
Guangzhou Medical University
2020
Third Affiliated Hospital of Guangzhou Medical University
2020
Baylor College of Medicine
2015-2016
The aim of the study was to evaluate role Smad3, Smad7, and TGF- β 1 in intrauterine adhesion (IUA) patients experimental rabbit models. 60 IUA patients, 30 control participants, 18 female rabbits were enrolled this study. We found that plasma concentrations protein expressions significantly increased compared those controls (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle="italic">0.05</mml:mn></mml:math>)....
RNA adenosine modifications, which are primarily mediated by "writer" enzymes (RMWs), play a key role in epigenetic regulation various biological processes, including tumorigenesis. However, the expression and prognostic of these genes osteosarcoma (OS) remain unclear.Univariate multivariate Cox analyses were used to construct RMW signature for OS using Target datasets. tissue was detected qPCR analysis. Xcell GSVA determine relationship between RMWs immune infiltration. The DGIdb CMap...
Abstract It has been found that long noncoding RNA HOTAIR, microRNA‐130a (miR‐130a) and insulin‐like growth factor 1 (IGF1) expression are associated with ovarian cancer, thus, we hypothesised the HOTAIR/miR‐130a/IGF1 axis might associate endocrine disorders biological behaviours of granulosa cells in rat models polycystic ovary syndrome (PCOS). PCOS were established by injection dehydro‐isoandrosterone, followed treatment si‐HOTAIR, oe‐HOTAIR, miR‐130a mimics or inhibitors. Serum hormonal...
Objective: Intrauterine adhesion (IUA) is one of the major causes refractory secondary infertility, especially in regions and countries with high abortion rates.In this study, we used mouse IUA model to evaluate feasibility organoids, a 3D cell structure derived from endometrial tissue, as grafts for treatment post-traumatic regeneration disorders.Methods: The isolated cultured organoid was transplanted into uterus by hydrogel scaffold method.Results: organoids were basal layer damaged...
The vaginal microbiota dysbiosis is closely associated with the development of reproductive diseases. However, contribution mycobiome to intrauterine adhesion (IUA) disease remains unknown. Harnessing 16S and ITS2 rDNA sequencing analysis, we investigate both bacterial fungal compositions across 174 samples taken from cervical canal (CC) middle vagina (MV) sites IUA patients. Overall, there no significant difference in microbial diversity between healthy subjects (HS) observe IUA-specific...
Background. As a transitional state between normal aging and Alzheimer’s disease (AD), mild cognitive impairment (MCI) is characterized by worse decline than that of natural aging. The association AD gut microbiota has been reported in number studies; however, microbial research regarding MCI remains limited. Methods. This study examined 48 participants, whom 22 were cases 26 control cases. Fecal samples collected for 16S ribosomal RNA (rRNA) quantitative arrays bioinformatics analysis....
Abstract This study is to evaluate the efficacy and safety of vaginoscopic incision oblique vaginal septum in adolescents with Obstructed hemi-vagina ipsilateral renal agenesis (OHVIRA) syndrome. It about Fourteen OHVIRA syndrome managed by using a “No-touch” technique over an 8-year period. In all fourteen was incised successfully without any intraoperative complications. Postoperative pain unremarkable each patient’s symptoms resolved postoperatively. The 3-month postoperative follow up...
Objective To investigate the long-term reintervention of ultrasound-guided high intensity focused ultrasound (USgHIFU) treatment for uterine fibroids and analyze factors affecting rate after USgHIFU.Materials methods Three hundred eight-one patients with treated by USgHIFU at third Xiangya Hospital Central South University from April 2012 to December 2014 were retrospectively reviewed. The that affect analyzed.Results mean follow-up time was 70.0 ± 9.0 months. During period, 86.4% (329/381)...
The gut microbiota is associated with reproductive disorders in multiple ways. This research investigated possible differences microbiome compositions between patients uterine fibroids (UFs) and healthy control subjects order to further provide new insight into its etiology. Stool samples were collected from 85 participants, including 42 UF (case group) 43 (control group). was examined 16S rRNA quantitative arrays bioinformatics analysis. α-diversity UFs significantly lower than that of...
The objective of this study was to explore the association between disordered vaginal microbiota and missed abortion ascertain potential causes related microbiology.This a prospective cohort with comparison group (reference group). Vaginal secretions from posterior fornix women in early stages pregnancy were collected Xiangya Third Hospital Central South University Changsha, Hunan, China, November 2018 2019. A total 54 cases (case group) 50 normal requiring induced analyzed. Bacterial DNA...
Iatrogenic injury to endometrial tissue is the main cause of intrauterine adhesions (IUA) and infection can also damage endometrium. The microbiota plays an important role in health female reproductive tract. However, mechanism still unclear. In total, 908 patients with IUA 11,389 healthy individuals were retrospectively selected for this clinical study. Participant information including vaginal microecological results human papillomavirus (HPV) status collected. Univariate multivariate...
To evaluate the efficacy and safety of oral ibrexafungerp (HS-10366) versus placebo in Chinese patients with vulvovaginal candidiasis (VVC).
Intrauterine adhesion (IUA) prevalence is difficult to measure, but appears have increased over the last few decades. The reproductive outcomes following hysteroscopic adhesiolysis (HA) for moderate-severe IUAs were unsatisfactory, and studies analyzed clinical characteristics pre-, intra- post-HA determine main risk factors infertility in patients with IUAs.This retrospective observational study included 406 patients, desiring fertility, who had undergone HA between January 1st, 2016 May...
Dysbiosis of the female reproductive tract is closely associated with gynecologic diseases. Here, we aim to explore association between dysbiosis in genital and uterine fibroids (UFs) further provide new insights into UF etiology. We present an observational study profile vaginal cervical microbiome from 29 women UFs 38 healthy women, 125 samples were obtained sequenced. By comparing microbial profiles different parts tract, there no significant difference diversity subjects patients....
Baicalein, a major flavonoid, possesses anticancer and anti-inflammatory activity. The aim of the study is to explore efficiency combination therapy with baicalein taxol, as well molecular mechanism on antitumor Human ovarian cancer cells were treated different concentration for 48 h, cell viability was determined by MTT assay. Baicalein inhibited proliferation cells, IC50 value in A2780 SKOV3 OVCAR 46.23, 60.68, 38.03 μM, respectively. 10 μM combined increasing taxol results demonstrated...
Some studies have demonstrated interactions of AD-risk single nucleotide polymorphisms (SNPs) in non-APOE regions with APOE genotype. Nevertheless, no study reported expression quantitative trait locus (eQTL) for In present study, we included 9286 unrelated AD patients and 8479 normal controls from 12 cohorts NIA Genetics Alzheimer's Disease Data Storage Site (NIAGADS) Neuroimaging Initiative (ADNI). 34 brain eQTLs were compiled BRAINEAC GTEx. We used multi-covariate logistic regression...
Intrauterine adhesion (IUA) is one of the most important causes female infertility, while iatrogenic endometrial injury main, but not entire, cause IUA. The microorganisms reproductive tract play an role in its health and disease. imbalance immune regulation caused by dysbacteriosis may be link formation mechanism uterine cavity adhesion.We prospectively enrolled 30 patients diagnosed with IUA women a history intrauterine surgery, without IUA, as control subjects. All participants were...
In this study, raw Cordyceps militaris polysaccharide (CPS) was extracted with ultrasonic- assisted extraction method. Proteins in the CPS were removed enzymatic and Sevag methods. After dialysis, an rate of 0.82% achieved. Two components, namely CPS-1 CPS-2, obtained from DEAE-52 ionic exchange chromatography eluted NaCl solution at a gradient 0 to 0.6 mol•L-1. The ultraviolet scanning demonstrated that did not couple protein nucleic acid, but CPS-2 coupled few proteins acids. product...