A5101476511- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Cancer-related gene regulation
- Spine and Intervertebral Disc Pathology
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- Cytokine Signaling Pathways and Interactions
- Cancer Mechanisms and Therapy
- Immune cells in cancer
- Head and Neck Surgical Oncology
- Heterotopic Ossification and Related Conditions
- Advanced Drug Delivery Systems
- Drug-Induced Hepatotoxicity and Protection
- Traditional Chinese Medicine Analysis
- Cancer Immunotherapy and Biomarkers
- Nanoparticle-Based Drug Delivery
- Pharmacogenetics and Drug Metabolism
- Peptidase Inhibition and Analysis
- Parathyroid Disorders and Treatments
- Medicinal Plant Pharmacodynamics Research
- Magnesium in Health and Disease
Central South University
2012-2024
Third Xiangya Hospital
2012-2024
Sichuan University
2009
Indiana University – Purdue University Indianapolis
2009
Indiana University School of Medicine
2009
Abstract N 6 -methyladenosine (m A) regulators are involved in the progression of various cancers via regulating m A modification. However, potential role and mechanism modification osteosarcoma remains obscure. In this study, WTAP was found to be highly expressed tissue it an independent prognostic factor for overall survival osteosarcoma. Functionally, WTAP, as oncogene, proliferation metastasis vitro vivo. Mechanistically, M dot blot, RNA-seq MeRIP-seq, MeRIP-qRT-PCR luciferase reporter...
The switch between osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a key role in aging-induced osteoporosis. In this study, miR-19a-3p was obviously downregulated BMSCs from aged humans mice. Overexpressed evidently reduced loss mice promoted BMSCs, while silenced manifestly increased repressed BMSCs. Hoxa5 significantly the contribute to miR-19a-3p-induced osteoblast as direct target gene miR-19a-3p. Furthermore, lncRNA Xist found sponge repress...
Mesoporous silica nanoparticles (MSNs) carrying gatekeepers that are stimuli-responsive widely investigated for the controlled delivery of drug at target sites. In this study, thioketal (TK) functionalized methoxy poly(ethylene glycol) (mPEG-TK) as ROS-responsive gatekeeper is used to modify MSNs and leads a reactive oxygen species (ROS)-responsive antibacterial drug. Vancomycin (Van) was taken then physically encapsulated into surface amino (N-MSNs). Subsequently, mPEG-TK immobilized. Van...
RNA adenosine modifications, which are primarily mediated by "writer" enzymes (RMWs), play a key role in epigenetic regulation various biological processes, including tumorigenesis. However, the expression and prognostic of these genes osteosarcoma (OS) remain unclear.Univariate multivariate Cox analyses were used to construct RMW signature for OS using Target datasets. tissue was detected qPCR analysis. Xcell GSVA determine relationship between RMWs immune infiltration. The DGIdb CMap...
Abstract The rapid multiplication of residual tumor cells and poor reconstruction quality new bone are considered the major challenges in postoperative treatment osteosarcoma. It is a promising candidate for composite scaffold which combines photothermal therapy (PTT) regeneration induction local However, it inevitable to damage normal tissues around due hyperthermia PTT, while mild heat shows limited effect on antitumor as can be easily repaired by stress‐induced shock proteins (HSP). This...
Abstract Tanshinone I (Tan I) is a widely used diterpene compound derived from the traditional Chinese herb Danshen. Increasing evidence suggests that it exhibits anti‐cancer activity in various human cancers. However, vitro and vivo effects of Tan on osteosarcoma (OS) remain inadequately elucidated, especially those against tumour metastasis. Our results showed significantly inhibited OS cancer cell proliferation, migration invasion induced apoptosis vitro. Moreover, treatment with 10 20...
In the system of magnesium-loaded scaffolds, effect magnesium ions (Mg2+ ) on osteogenesis induction is restricted due to low transmembrane transport efficiency Mg2+ into cell, which limits application for bone defect repair. Inspired by fact that magnetic field can regulate ion channel proteins cell membrane, magnetite nanoparticle introduced poly (l-lactic acid) /magnesium oxide composite in this study, and a scaffold prepared via selective laser sintering . Notably, activities protein...
Studies have shown that miR-194 functions as a tumour suppressor and is associated with growth metastasis. This study intends to uncover the mechanism of suppression by miR-194. The expression in osteosarcoma cell lines tissues were monitored real-time PCR.The proliferation ability was examined MTT assay. Migration apoptosis cells migration assay flow cytometry, respectively. regulation on CDH2 determined luciferase assays western blot assays.The results showed significantly reduced compared...
So far, microRNA has attracted plenty of interest due to its role in tumorigenesis. Reportedly, miR-181b may be involved the tumorigenesis osteosarcoma (OS). In current study, we attempted investigate detailed function and mechanism OS carcinogenesis. Herein, miR-181a, miR-181b, miR-181c, miR-181d expressions tissues were higher than that nontumor tissue samples as examined real-time polymerase chain reaction. Via direct targeting, negatively regulated expression phosphatase tensin homolog...
Abstract Bruceantinol (BOL) is a quassinoid compound found in the fruits of Brucea javanica. Previous research has highlighted manifold physiological and pharmacological activities BOL. Notably, BOL demonstrated antitumor cytotoxic antibacterial effects, lending support to its potential as promising therapeutic agent for various diseases. Despite being recognized potent inhibitor multiple cancer types, efficacy against osteosarcoma (OS) not been elucidated. In this work, we investigated...
Wilms' tumor 1 associated protein (WTAP) is an essential component of the m6A methyltransferase complex. The research on WTAP has been continuously developed and promoted in recent years. It needed to make systematic specific bibliometric database analyses WTAP, identify cooperation impact authors, countries, institutions journals, evaluate knowledge base find hotspot trends, detect emerging topics regarding research. related articles reviews Web Science Core Collection from January 1999...
Osteosarcoma is a highly aggressive primary malignant bone tumor commonly seen in children and adolescents, with poor prognosis. Anchorage-dependent cell death (anoikis) has been proven to be indispensable metastasis, regulating the migration adhesion of cells at site. However, as type programmed death, anoikis rarely studied osteosarcoma, especially immune microenvironment. This study aims clarify prognostic value microenvironment-related gene treatment osteosarcoma.
Background: N6-methyladenosine (m6A) regulators are involved in the progression of various cancers via regulating m6A modification. However, potential role and mechanism modification osteosarcoma (OS) remains obscure. Methods: The expression were detected using qPCR western blot. Cell proliferation, colony formation, wound healing transwell invasion assays used to reveal WTAP OS. WTAP-mediated was explored M6A dot blot, RNA-seq MeRIP-seq, MeRIP-qRT-PCR luciferase reporter assays. Results:...
An innovative prone cervical spine surgical position using a body-shape plaster bed with skull traction (BSPST) was compared the traditional horseshoe headrests.A total of 47 patients, undergoing posterior surgery for fracture, were retrospectively classified into two groups, BSPST group (n = 24) and 23), underwent instrumented fusion or without decompression. Multiple indicators used to evaluate advantages position.All operations went smoothly. The mean recovery rate 56.30% in 48.55% (p...
Abstract Although neoadjuvant chemotherapy combined with surgical resection improved the prognosis of patients osteosarcoma, there was no significant effect on metastatic and recurrent osteosarcoma. Immunotherapy seems to have turned corner. However, as an important target immunotherapy, relationship between phenotype Tumor-associated macrophages osteosarcoma remains unclear. In single-cell RNA sequencing, immunotherapy in microenvironment analyzed, hub genes closely related macrophage...
Abstract Background A modified prone cervical spine surgical position using a body-shape plaster bed with skull traction (BSPST) was compared the traditional horseshoe headrests. Methods Forty-seven patients undergoing posterior surgery for fracture were retrospectively classified into two groups, BSPST group (n = 24) and 23) underwent instrumented fusion or without decompression. Multiple indicators used to evaluate advantages of position. Results All operations went smoothly. The mean...
Abstract Background RNA adenosine modifications, mediated mainly by the “writer” enzymes (RMWs), play a key role in epigenetic regulation various biological processes, including tumorigenesis. However, expression and prognosis of these genes osteosarcoma (OS) remains unclear. Methods The univariate multivariate cox analyses were used to construct RMWs signature OS using Target datasets. tissue detected qPCR analysis. Xcell GSVA for relationship between immune infiltration. DGIdb CMap...