A5101916208- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- MicroRNA in disease regulation
- Dendrimers and Hyperbranched Polymers
- Circular RNAs in diseases
- Cancer-related gene regulation
- Analytical Chemistry and Chromatography
- Bone Metabolism and Diseases
- biodegradable polymer synthesis and properties
- Remote Sensing and Land Use
- Graphene and Nanomaterials Applications
- Catalytic Processes in Materials Science
- Peptidase Inhibition and Analysis
- Multiple Sclerosis Research Studies
- Mesenchymal stem cell research
- Coordination Chemistry and Organometallics
- Bone Tissue Engineering Materials
- Axial and Atropisomeric Chirality Synthesis
- HVDC Systems and Fault Protection
- Oxidative Organic Chemistry Reactions
- Asymmetric Synthesis and Catalysis
- Surface Chemistry and Catalysis
- Systemic Lupus Erythematosus Research
- Catalytic C–H Functionalization Methods
Changsha Medical University
2015-2024
Abstract N 6 -methyladenosine (m A) regulators are involved in the progression of various cancers via regulating m A modification. However, potential role and mechanism modification osteosarcoma remains obscure. In this study, WTAP was found to be highly expressed tissue it an independent prognostic factor for overall survival osteosarcoma. Functionally, WTAP, as oncogene, proliferation metastasis vitro vivo. Mechanistically, M dot blot, RNA-seq MeRIP-seq, MeRIP-qRT-PCR luciferase reporter...
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an immune-mediated inflammatory demyelinating of the central nervous system. This study aimed to delineate clinical manifestations, imaging features, and long-term outcomes in Chinese patients with MOGAD analyze recurrence-associated factors. The phenotypic neuroimaging characteristics 15 Han were retrospectively analyzed. Demyelinating attacks, MOG antibodies cerebrospinal fluid/serum, response immunotherapy,...
RNA adenosine modifications, which are primarily mediated by "writer" enzymes (RMWs), play a key role in epigenetic regulation various biological processes, including tumorigenesis. However, the expression and prognostic of these genes osteosarcoma (OS) remain unclear.Univariate multivariate Cox analyses were used to construct RMW signature for OS using Target datasets. tissue was detected qPCR analysis. Xcell GSVA determine relationship between RMWs immune infiltration. The DGIdb CMap...
A mesoporous bioactive glass (MBG) surface modified with poly(lactic-co-glycolic acid) (PLGA) electrospun fibrous scaffold for bone regeneration was prepared by dip-coating a PLGA into MBG precursor solution. Different structures and properties were acquired different coating times. Surface morphology, chemical composition, microstructure, pore size distribution, hydrophilicity of the PLGA-MBG characterized. Results scanning electron microscopy indicated that made rougher increase content....
The disturbance of homeostasis in bone marrow-derived mesenchymal stem cell (BMSC) adipogenesis and osteogenesis could result pathologic consequences that plays a critical role osteoporosis pathogenesis. In the present study, we demonstrated miR-210-3p was abnormally upregulated within femur patients downregulated osteogenically differentiated BMSCs. predicted targets candidate miRNAs were enriched Pluripotent differentiation signaling. KRAS, as vital factor KRAS/MAPK/ERK signaling,...
A visible-light irradiation tandem oxidative aryl migration/carbonyl formation reaction, mediated by K 2 S O 8 and photoredox catalysis, has been discovered.
Monodisperse polyethylene glycol monomethyl ether and chiral glycidyl tosylate were utilized as substrates in the synthesis of monomer unit epoxypropyl (MPEG-EPO). The initiator propargyl-terminated alkyne-PEG3-OH was employed, while phosphazene base P4-t-Bu facilitated controlled ROP MPEG-EPO, resulting clickable dendritic P(MPEG-EPO) with terminal alkyne. four-arm polymer 4-Arm-PEG3-Mn synthesized through a click reaction between 4-Arm-PEG3-N3 P(MPEGn-EPO) using Cu(PPh3)3Br/CuBr catalyst....
Background: N6-methyladenosine (m6A) regulators are involved in the progression of various cancers via regulating m6A modification. However, potential role and mechanism modification osteosarcoma (OS) remains obscure. Methods: The expression were detected using qPCR western blot. Cell proliferation, colony formation, wound healing transwell invasion assays used to reveal WTAP OS. WTAP-mediated was explored M6A dot blot, RNA-seq MeRIP-seq, MeRIP-qRT-PCR luciferase reporter assays. Results:...
Abstract Background RNA adenosine modifications, mediated mainly by the “writer” enzymes (RMWs), play a key role in epigenetic regulation various biological processes, including tumorigenesis. However, expression and prognosis of these genes osteosarcoma (OS) remains unclear. Methods The univariate multivariate cox analyses were used to construct RMWs signature OS using Target datasets. tissue detected qPCR analysis. Xcell GSVA for relationship between immune infiltration. DGIdb CMap...