A5100706861- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Medical Imaging Techniques and Applications
- Bone Tissue Engineering Materials
- Dialysis and Renal Disease Management
- Graphene and Nanomaterials Applications
- Advanced Image Processing Techniques
- Venous Thromboembolism Diagnosis and Management
- Nanoplatforms for cancer theranostics
- PI3K/AKT/mTOR signaling in cancer
- Extracellular vesicles in disease
- interferon and immune responses
- Cancer therapeutics and mechanisms
- Vascular Malformations and Hemangiomas
- Nanoparticle-Based Drug Delivery
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Vascular Tumors and Angiosarcomas
- Cancer, Hypoxia, and Metabolism
- Image Enhancement Techniques
Huanggang Normal University
2025
Fudan University
2024
Satellite Healthcare (United States)
2020-2024
Central South University
2015-2024
Third Xiangya Hospital
2015-2024
Stomatology Hospital
2022-2024
Sun Yat-sen University
2022-2024
Xuzhou Medical College
2023-2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
The aggregation of graphene oxide (GO) is considered as main challenge, although GO possesses excellent mechanical properties which arouses widespread attention reinforcement for polymers.In this study, silicon dioxide (SiO2) nanoparticles were decorated onto surface nanosheets through in situ growth method promoting dispersion poly(l-lactic acid) (PLLA) bone scaffold.Hydroxyl and carboxyl functional groups provided sites SiO2 nucleation, grew with hydrolysis polycondensation tetraethyl...
Lumbar facet joint osteoarthritis (LFJ OA) is regarded as one of the common causes low back pain (LBP). The pathogenesis and underlying mechanism this disease are largely unknown, there still no effective disease-modifying therapy. This study aims to investigate efficacy exosomes derived from bone marrow mesenchymal stem cells (BMSCs) on behavioral signs LBP in LFJ OA mouse model. pathogenetic change cartilage aberrant nerve invasion subchondral a model after treatment with BMSC-exosomes was...
Mesoporous silica nanoparticles (MSNs) carrying gatekeepers that are stimuli-responsive widely investigated for the controlled delivery of drug at target sites. In this study, thioketal (TK) functionalized methoxy poly(ethylene glycol) (mPEG-TK) as ROS-responsive gatekeeper is used to modify MSNs and leads a reactive oxygen species (ROS)-responsive antibacterial drug. Vancomycin (Van) was taken then physically encapsulated into surface amino (N-MSNs). Subsequently, mPEG-TK immobilized. Van...
The cGAS-STING pathway, as a vital innate immune signaling has attracted considerable attention in tumor immunotherapy research. However, STING agonists are generally incapable of targeting tumors, thus limiting their clinical applications. Here, photodynamic polymer (P1) is designed to electrostatically couple with 56MESS-a cationic platinum (II) agent-to form NPPDT -56MESS. accumulation -56MESS the tumors increases efficacy and decreases systemic toxicity drugs. Moreover, generates...
Abstract The rapid multiplication of residual tumor cells and poor reconstruction quality new bone are considered the major challenges in postoperative treatment osteosarcoma. It is a promising candidate for composite scaffold which combines photothermal therapy (PTT) regeneration induction local However, it inevitable to damage normal tissues around due hyperthermia PTT, while mild heat shows limited effect on antitumor as can be easily repaired by stress‐induced shock proteins (HSP). This...
This study investigated the role of miR-143 in chemoresistance osteosarcoma tumor cells and associated mechanisms. Real-time PCR was used to measure levels. Western blot detect protein expression. Cell proliferation analyzed by MTT assay Matrigel colony formation assay. Forced expression established adenoviral vector infection. death detected Hoechst33342 staining. Loss observed osteosarcomas, which correlated with shorter survival patients osteosarcomas underlying chemotherapy. In...
Abstract Tanshinone I (Tan I) is a widely used diterpene compound derived from the traditional Chinese herb Danshen. Increasing evidence suggests that it exhibits anti‐cancer activity in various human cancers. However, vitro and vivo effects of Tan on osteosarcoma (OS) remain inadequately elucidated, especially those against tumour metastasis. Our results showed significantly inhibited OS cancer cell proliferation, migration invasion induced apoptosis vitro. Moreover, treatment with 10 20...
Diamagnetic metal sulfonates have been widely reported, while paramagnetic species are very rare, especially those that exhibit interesting magnetic and/or proton conduction properties. Herein, we report the synthesis, structure, magnetic, and proton-conducting properties of a hydrogen-bonded cobalt(II) organosulfonate complex. The coordination self-assembly CoII salts 8-quinolinesulfonic acid ligands affords mononuclear sulfonate featuring both coordinated noncoordinated sulfonic O atoms...
Background and objectives Mobile health is the care use of mobile devices, such as smartphones. readiness a prerequisite to successful implementation programs. The aim this study was examine status correlates among individuals on dialysis. Design, setting, participants, & measurements A cross-sectional 30-item questionnaire guided by Khatun conceptual model distributed dialysis from 21 in-center hemodialysis facilities 14 home centers. survey assessed availability devices internet,...
Indobufen is a new generation of anti-platelet aggregation drug, but studies were not sufficient on its anticoagulant effects. In the present study, activity indobufen was determined by monitoring activated partial thromboplastin time (APTT), prothrombin (PT), and thrombin (TT) in rabbit plasma. We evaluated mechanisms content platelet factor 3,4 (PF3,4), coagulation 1, 2, 5, 8, 10 (FI, II, V, VIII, X) rabbits, as well vivo bleeding clotting mice. The pharmacodynamic differences between...
ABSTRACT In the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated decreased bone vasculature and induce osteoporosis growth failure. The mechanism GC-suppression relationship to retardation remains largely unknown. Type H vessels, which regulated by preosteoclast (POC) platelet-derived factor–BB (PDGF-BB), specifically formation development. We determined effect GCs on POC synthesis PDGF-BB in relation type...
Peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of adipocyte differentiation, glucolipid metabolism, and inflammation. Thiazolidinediones are PPARγ full agonists with potent insulin-sensitizing effects, whereas their oral usage restricted because unwanted side including obesity cardiovascular risks. Here, via virtual screening, microscale thermophoresis analysis, molecular confirmation, we demonstrate that diosmin, natural compound wide long-term clinical use,...
Abstract Introduction To summarize the development of Innovative Undergraduate Dental Talents Training Project (IUDTTP) and investigate training effect this extracurricular dental basic research education activity from 2015 to 2020 obtain educational implications. Materials Methods The Guanghua School Stomatology established IUDTTP in 2015. authors recorded process analysed participation situation, effect, academic performance overall satisfaction during 2015–2020 through documental...