A5100726275- Advanced biosensing and bioanalysis techniques
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Nanocluster Synthesis and Applications
- Extracellular vesicles in disease
- Crystallography and molecular interactions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Quantum Dots Synthesis And Properties
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Molecular Junctions and Nanostructures
- Polymer Surface Interaction Studies
- Molecular Sensors and Ion Detection
- Metal-Organic Frameworks: Synthesis and Applications
- Microfluidic and Bio-sensing Technologies
- Analytical Chemistry and Sensors
- Advanced Photocatalysis Techniques
- Advanced Polymer Synthesis and Characterization
- Spectroscopy and Chemometric Analyses
Macquarie University
2017-2025
Xinyang Normal University
2016-2025
Henan University of Science and Technology
2025
Fuzhou University
2013-2025
Henan Institute of Science and Technology
2022-2024
Huainan Normal University
2024
Anhui Agricultural University
2020-2024
Anhui University
2024
Shanghai Jiao Tong University
2013-2024
Australian Research Council
2018-2024
Abstract Have you seen the film? Coupling a spray‐coating technique with facile, low‐cost, efficient and environmentally friendly electrochemical method may realize controllable synthesis of large‐area patterned electrochemically reduced graphene oxide films on various conductive insulating substrates thicknesses ranging from single monolayer to several microns (see figure). magnified image
Recent advances in fluorescent metal nanoclusters have spurred tremendous interest nanomedicine due to the ease of fabrication, excellent biocompatibility, and, more importantly, wavelength-dependent tunability. Herein, we report our findings on BSA-protected gold (AuNCs), ∼2 nm size conjugated with Herceptin (AuNCs-Her), for specific targeting and nuclear localization ErbB2 over-expressing breast cancer cells tumor tissue as a novel agent simultaneous imaging therapy. More interestingly,...
Nucleic acid amplification is a powerful molecular biology tool, although its use outside the modern laboratory environment limited due to relatively cumbersome methods required extract nucleic acids from biological samples. To address this issue, we investigated variety of materials for their suitability capture and purification. We report here that untreated cellulose-based paper can rapidly within seconds retain them during single washing step, while contaminants present in complex...
Abstract The inside walls of a nanopipette tip are decorated by Pt deposit that is used as an open bipolar electrochemiluminescence (ECL) device to achieve intracellular wireless electroanalysis. synergetic actions and ECL lead the spatial confinement voltage drop at level deposit, which generates emission from luminol. porous structure permits electrochemical transport molecules into coupled with enzymatic reactions. Thus, concentrations hydrogen peroxide or glucose measured in vivo well...
Rechargeable aqueous zinc-ion batteries (ZIBs) have attracted extensive attention due to their low cost and high safety. However, the critical issues of dendrite growth side reactions on Zn metal anode hinder commercialization ZIBs. Herein, we demonstrated that formation Zn4SO4(OH)6·5H2O byproducts is closely relevant direct contact between electrode SO42-/H2O. On basis this finding, developed a cation-exchange membrane perfluorosulfonic acid (PFSA) coated surface regulate plating/stripping...
Abstract The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets cancer patients. However, they carry and sometimes life-threatening toxicities. Prompt prediction monitoring toxicities have the potential to maximise benefits therapy. Herein, we develop a digital nanopillar SERS platform that achieves real-time single cytokine counting enables dynamic tracking patients receiving inhibitor treatment - broader applications are...
Despite the tremendous progress in neural radiance fields (NeRF), we still face a dilemma of trade-off between quality and efficiency, e.g., MipNeRF [3] presents fine-detailed anti-aliased renderings but takes days for training, while Instant-ngp [36] can accomplish reconstruction few minutes suffers from blurring or aliasing when rendering at various distances resolutions due to ignoring sampling area. To this end, propose novel Tri-Mip encoding (à la "mipmap") that enables both instant...
Fibrosis is a process of tissue repair that results in the slow creation scar to replace healthy and can affect any or organ. Its primary feature massive deposition extracellular matrix (mainly collagen), eventually leading dysfunction organ failure. The progression fibrotic diseases has put significant strain on global health economy, as result, there an urgent need find some new therapies. Previous studies have identified inflammation, oxidative stress, cytokines, remodeling play crucial...
Abstract Liquid biopsy has emerged as a promising non-invasive strategy for cancer diagnosis, enabling the detection of various circulating biomarkers, including tumor cells (CTCs), nucleic acids (ctNAs), tumor-derived small extracellular vesicles (sEVs), and proteins. Surface-enhanced Raman scattering (SERS) biosensors have revolutionized liquid by offering sensitive specific methodologies these biomarkers. This review comprehensively examines application SERS-based identification analysis...
Investigation of charge transfer needs analytical tools that could reveal this phenomenon, and enables understanding its effect at the molecular level. Here, we show how combination using gold nanoclusters (AuNCs) different spectroscopic techniques be employed to investigate thiolated molecules on nanoparticles (AuNP@Mol). It was found in molecule affected by AuNCs, evidenced amplification surface-enhanced Raman scattering (SERS) signal changes fluorescence lifetime AuNCs. Density functional...
Oxygen vacancies (O
We performed a multistage genome-wide association study of melanoma. In discovery cohort 1804 melanoma cases and 1026 controls, we identified loci at chromosomes 15q13.1 (HERC2/OCA2 region) 16q24.3 (MC1R) regions that reached significance within this also found strong evidence for genetic effects on susceptibility to from markers chromosome 9p21.3 in the p16/ARF region 1q21.3 (ARNT/LASS2/ANXA9 region). The most significant single-nucleotide polymorphisms (SNPs) locus (rs1129038 rs12913832)...
Aptamers, which are in vitro selected functional oligonucleotides, have been employed to design novel biosensors (i.e., aptasensors) due their inherent selectivity, affinity, and multifarious advantages over traditional recognition elements. In this work, we reported a multifunctional reusable label-free electrochemical biosensor based on an integrated aptamer for parallel detection of adenosine triphosphate (ATP) α-thrombin, by using impedance spectroscopy (EIS) cyclic voltammetry (CV). A...
SERS aptasensors for protein recognition based on Au nanoparticles labeled with aptamers and Raman reporters have been developed, which opens a new way of high sensitivity selectivity.
SERS biosensor for sensitive and selective detection of lead ions (Pb2+) based on DNAzyme was developed by taking advantage the specific catalytic reaction upon binding to Pb2+ ions. Detection accomplished nanoprobe labeled with DNA Raman reporters signal amplification.
Abstract Developing quick and sensitive molecular diagnostics for plant pathogen detection is challenging. Herein, a nanoparticle based electrochemical biosensor was developed rapid of DNA on disposable screen-printed carbon electrodes. This 60 min assay relied the isothermal amplification target sequences by recombinase polymerase (RPA) followed gold nanoparticle-based assessment with differential pulse voltammetry (DPV). Our method 10,000 times more than conventional chain reaction...
SERS labels are a new class of nanotags for optical detection based on Raman scattering. Central advantages include their spectral multiplexing capacity due to the small line width vibrational bands, quantification intensities, high photostability, minimization autofluorescence from biological specimens via red near-infrared (NIR) excitation, and need only single laser excitation line. Current concepts rational design synthesis summarized in this review. Chemical constituents plasmonically...
The identification and timely detection of pathogenic bacteria is critical to ensuring safe food, health, water. Although surface enhanced Raman scattering (SERS) methods have been used for pathogen characterization single molecule sensing, the challenge detecting pathogens in very low numbers using an optimal substrate that sensitive reproducible still a challenge. In this report, we developed explored novel SERS active 60−80 nm diameter through assembly Ag nanocrystals (AgNCs) into...
Nanoparticles are increasingly being used to investigate biological processes in various animal models due their versatile chemical, unique optical, and multifunctional properties. In this report we address the biocompatibility biodistribution of nanoparticle sensors for Raman chemical imaging live zebrafish (Danio rerio) embryos. Surface-enhanced scattering (SERS) nanoprobes (NPs) comprising gold nanoparticles (AuNPs) as enhancing substrate nonfluorescent labels were synthesized...
Monitoring targeted therapy in real time for cancer patients could provide vital information about the development of drug resistance and improve therapeutic outcomes. Extracellular vesicles (EVs) have recently emerged as a promising biomarker, EV phenotyping shows high potential monitoring treatment responses. Here, we demonstrate feasibility patient responses based on plasma phenotypic evolution using multiplex phenotype analyzer chip (EPAC). EPAC incorporates nanomixing-enhanced microchip...