A5051954845- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Epigenetics and DNA Methylation
- Gold and Silver Nanoparticles Synthesis and Applications
- Microfluidic and Bio-sensing Technologies
- Extracellular vesicles in disease
- Advanced Biosensing Techniques and Applications
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Gut microbiota and health
- 3D Printing in Biomedical Research
- Environmental DNA in Biodiversity Studies
- Probiotics and Fermented Foods
- Microfluidic and Capillary Electrophoresis Applications
- Nanocluster Synthesis and Applications
- Genomics and Chromatin Dynamics
- Electrohydrodynamics and Fluid Dynamics
- Cancer-related gene regulation
- CAR-T cell therapy research
- Advanced Proteomics Techniques and Applications
- Nanopore and Nanochannel Transport Studies
- Medical Imaging and Pathology Studies
- Genomics and Phylogenetic Studies
- Single-cell and spatial transcriptomics
- Monoclonal and Polyclonal Antibodies Research
The University of Queensland
2016-2025
Columbia University Irving Medical Center
2023-2024
Columbia University
2023
Dana-Farber Cancer Institute
2022
Harvard University
2022
Brisbane School of Theology
2016-2020
Institute of Bioengineering and Nanotechnology
2014-2020
Shahjalal University of Science and Technology
2014-2019
Corner House
2018-2019
Abstract The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets cancer patients. However, they carry and sometimes life-threatening toxicities. Prompt prediction monitoring toxicities have the potential to maximise benefits therapy. Herein, we develop a digital nanopillar SERS platform that achieves real-time single cytokine counting enables dynamic tracking patients receiving inhibitor treatment - broader applications are...
Abstract Epigenetic reprogramming in cancer genomes creates a distinct methylation landscape encompassing clustered at regulatory regions separated by large intergenic tracks of hypomethylated regions. This that we referred to as Methylscape is displayed most types, thus may serve universal biomarker. To-date research has focused on the biological consequences DNA changes whereas its impact physicochemical properties remains unexplored. Herein, examine effect levels and genomic distribution...
Sequence-dependent non-thiolated DNA–gold affinity interaction for biosensing applications, and the underlying principles governing these interactions are comprehensively reviewed.
Abstract Tumor-derived exosomes possess significant clinical relevance due to their unique composition of genetic and protein material that is representative the parent tumor. Specific isolation as well identification proportions these clinically relevant (CREs) from biological samples could help better understand significance cancer biomarkers. Herein, we present a simple approach for quantification proportion CREs within bulk exosome population isolated patient serum. This can potentially...
Monitoring targeted therapy in real time for cancer patients could provide vital information about the development of drug resistance and improve therapeutic outcomes. Extracellular vesicles (EVs) have recently emerged as a promising biomarker, EV phenotyping shows high potential monitoring treatment responses. Here, we demonstrate feasibility patient responses based on plasma phenotypic evolution using multiplex phenotype analyzer chip (EPAC). EPAC incorporates nanomixing-enhanced microchip...
Cancer is a dynamic disease with heterogenic molecular signatures and constantly evolves during the course of disease. Single cell proteomic analysis could offer suitable pathway to monitor cancer heterogeneity deliver critical information for diagnosis, recurrence, drug-resistant mechanisms in cancer. Current standard techniques such as ELISA, mass spectrometry, Western blots are time-consuming, expensive, often require fluorescence labeling that fails provide accurate about multiple...
Environmental pollution has been a significant concern for the last few years. The leather industry significantly contributes to economy but is one of Bangladesh’s most prominent polluting industries. It also responsible several severe diseases such as cancer, lung diseases, and heart workers because they use bleaching agents chemicals, these have numerous adverse effects on human health. study was aimed at isolating, identifying, molecularly characterizing bacteria that produce protease...
DNA regional methylation can be detected in real-time and label-free using surface plasmon resonance biosensing coupled to molecular inversion probe based amplification.
Base dependent affinity interaction of DNA with gold has been utilised to electrochemically quantify the methylation status bisulphite treated samples.
Liquid biopsy-based diagnosis in precision oncology exhibits significant advantages over the traditional tissue biopsies by offering dynamic assessment of tumour heterogeneity, minimally invasive procedures for frequent sampling, and cost-effective tests.
Accurate identification of malignant lung lesions is a prerequisite for rational clinical management to reduce morbidity and mortality cancer. However, classification nodules into benign cases difficult as they show similar features in computer tomography sometimes positron emission imaging, making invasive tissue biopsies necessary. To address the challenges evaluating indeterminate nodules, authors investigate molecular profiles small extracellular vesicles (sEVs) differentiating via...
Immune checkpoint proteins (ICPs) play a major role in patient's immune response against cancer. Tumour cells usually express those to communicate with as process of escaping the anti-cancer response. Detecting functional present on cancer (such circulating tumor or CTCs) and examining heterogeneity their expression at single-cell level could crucial both diagnosis monitoring therapy. In this study, we develop mesoporous gold biosensor precisely assess ICP individual within lung model. The...
The analysis of DNA methylation is becoming increasingly important both in the clinic and also as a research tool to unravel key epigenetic molecular mechanisms biology. Current methodologies for quantification regional (i.e., average over region genome) are largely affected by comprehensive sequencing which tend be expensive, tedious, time-consuming many applications. Herein, we report an alternative detection method referred "Methylsorb", based on inherent affinity bases gold surface trend...
A simple, sensitive and inexpensive electrochemical method has been reported to detect regional DNA methylation by using differential adsorption affinity of bases gold.
Abstract The field of precision oncology is rapidly progressing toward integrated “multiomics” analysis multiple molecular species (such as DNA, RNA, or proteins) to provide a more complete profile tumor heterogeneity. Micro/nanomaterial‐based systems, which leverage the unique properties miniature materials, are currently well positioned expand beyond rudimentary biomarker detection multiomics signature analysis. To enable clinical translation, rational design and implementation...
Identifying small extracellular vesicle (sEV) subpopulations based on their different molecular signatures could potentially reveal the functional roles in physiology and pathology. However, it is a challenge to achieve this aim due nano-sized dimensions of sEVs, low quantities biological cargo each sEV carries, our incomplete knowledge identifying features capable separating heterogeneous subpopulations. Here, sensitive, multiplexed, nano-mixing-enhanced subpopulation characterization...
Circulating biomarkers have emerged as promising non-invasive, real-time surrogates for cancer diagnosis, prognosis and monitoring of the therapeutic response. Current bio-sensing techniques mostly involve detection either circulating cells or proteins which are inadequate in unfolding complex pathologic transformations. Herein, we report parallel cellular molecular markers (protein) using a multiplex platform featuring (i) graphene oxide (GO) functionalization that increases active surface...