A5004037450- Computational Drug Discovery Methods
- Metallurgical Processes and Thermodynamics
- Antimicrobial Peptides and Activities
- Drug Transport and Resistance Mechanisms
- Immune Response and Inflammation
- Mesenchymal stem cell research
- Protein Structure and Dynamics
- Cancer-related molecular mechanisms research
- Oral microbiology and periodontitis research
- Inflammasome and immune disorders
- Advanced ceramic materials synthesis
- Advanced Sensor and Energy Harvesting Materials
- Spacecraft Dynamics and Control
- Endodontics and Root Canal Treatments
- Astro and Planetary Science
- Space Satellite Systems and Control
- Cholinesterase and Neurodegenerative Diseases
- MicroRNA in disease regulation
- Tactile and Sensory Interactions
- Phosphodiesterase function and regulation
- vaccines and immunoinformatics approaches
- Recycling and utilization of industrial and municipal waste in materials production
- Medical and Biological Sciences
- Machine Learning in Bioinformatics
- Microbial Inactivation Methods
Stomatology Hospital
2016-2025
Hainan University
2023-2025
Chongqing University
2015-2024
Sun Yat-sen University
2015-2024
Yangzhou University
2024
Institute of Electronics
2024
Politecnico di Milano
2020-2022
University of Toronto
2022
Hospital for Sick Children
2022
Southwest Medical University
2022
Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and limited efficacy, hampered clinical application. These drawbacks can be largely reduced by replacing the traditional 2D culture system with a 3D system. However, potential function of MSC-exos produced (3D-exos) periodontitis remains elusive. This study showed that compared generated via (2D-exos), 3D-exos enhanced...
Exosomes are important mediators of intercellular communication and have a vital part in the diagnosis treatment various diseases humans. Here, we investigated benefits underlying mechanism exosomes secreted via stem cells from human exfoliated deciduous teeth (SHED-derived exosomes) promoting alveolar bone regeneration, thus providing new insights into exosome-based therapy for periodontitis. SHED-derived were isolated by ultracentrifugation. The impacts on angiogenic ability umbilical vein...
Abstract Supramolecular self‐assembly of near‐infrared (NIR) dyes are believed to be a promising strategy design effective photothermal agents for tumor therapy (PTT). However, due the uncontrollable intermolecular interactions, accurately fine‐tuning aggregated morphology NIR through adjusting their supramolecular is challenging. Here, based on organic–metal coordination interaction, facile proposed adjust heptamethine cyanine (Cy7) dyes, well‐known dyes. Three hydrophilic Cy7 derivatives...
Electroporation and electrofusion are efficient methods, which have been widely used in different areas of biotechnology medicine. Pulse strength width, as an external condition, play important role the process these methods. However, comparatively little work has done to explore effects pulsed electric field parameters on electroporation electrofusion. Herein, influences pulse width phospholipid bilayers were systematically investigated by using experiments combined with molecular dynamics...
A highly selective ferroptosis inducer with drug-like properties can significantly advance the research on inducing for anticancer treatment. We previously reported a active GPX4 inhibitor 26a, but its activity and stability need further improvement. In this work, novel (R)-9i more potent cytotoxicity (IC50 = 0.0003 μM against HT1080) selectivity (selectivity index 24933) was gained via electrophilic warhead screening structure-based optimization. The cellular thermal shift assay (CETSA)...
Abstract Aim Clinical and in vitro evidence indicates that chronic inflammatory responses initiated by dental caries can persist the pulp even after treatment, necessitating formation of reparative dentin to restore tissue homeostasis health. Human stem cells (hDPSCs) serve as crucial precursors this process. This study explores role B their secreted factor, Angiopoietin Like 1 (ANGPTL1), promoting hDPSCs differentiation into odontoblasts under carious conditions, with a particular focus on...
The anticancer agent irinotecan often induces severe delayed-onset diarrhea, inhibiting human carboxylesterase 2A (hCES2A) can significantly alleviate irinotecan-triggered gut toxicity (ITGT). This work presents an efficient workflow for de novo design and developing novel efficacious hCES2A inhibitors. A well-training machine learning model identified scaffold-14 as a lead compound, while compound 14n was developed time-dependent inhibitor (IC50 = 0.04 nM) following three rounds of...
Radiation-induced oral mucositis affects patient quality of life and reduces tolerance to cancer therapy. Unfortunately, traditional treatments are insufficient for the treatment might elicit severe side effects. Due their immunomodulatory anti-inflammatory properties, transplantation mesenchymal stem cells (MSCs) is a potential therapeutic strategy mucositis. However, systemically infused MSCs rarely reach inflamed sites, impacting clinical efficacy. Previous studies have demonstrated that...
Electronic skin is an important means through which robots can obtain external information. A novel flexible tactile sensor capable of simultaneously detecting the contact position and force was proposed in this paper. The had a three-layer structure. upper layer specially designed conductive film based on indium-tin oxide polyethylene terephthalate (ITO-PET), could be used for position. intermediate piezoresistive as force-sensitive element. lower made fully material such aluminum foil only...
Novel ecological antimicrobial approaches to dental caries focus on inhibiting cariogenic pathogens while enhancing the growth of health-associated commensal communities or suppressing virulence without affecting diversity oral microbiota, which emphasize crucial role establishing a healthy microbiome in prevention. Considering that acidified microenvironment leads dysbiosis microecology and demineralization enamel, exploiting acidic pH as bioresponsive trigger help materials medications...
To investigate the function of miRNAs in odontoblast-like differentiation human dental pulp cells (hDPCs).Integrated comparative miRNA microarray profiling was used to determine differential expression hDPCs. The abundance microRNA-135b (miR-135b) measured by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) and situ hybridization (ISH). Bioinformatic analyses combined with luciferase assays were utilized identify targets interacting miR-135b. Overexpression...
No general rules exist for constellation design; instead, designers have to consider various cost drivers in a trade-off way. This paper presents systematic method the design of continuous global coverage Walker and Street-of-Coverage constellations, by taking seven critical properties (coverage, robustness, self-induced collision avoidance, launch, build-up, station-keeping, end-of-life disposal) as criteria. In this method, set characteristic parameters, which can determine configuration,...
Phosphodiesterase 1 (PDE1) is a subfamily of PDE super enzyme families that can hydrolyze cyclic adenosine monophosphate and guanosine simultaneously. Currently, the number PDE1 inhibitors relatively few, significantly limiting their application. Herein, novel series quinolin-2(1H)-ones were designed rationally, leading to compound 10c with an IC50 15 nM against PDE1C, high selectivity across other PDEs, remarkable safety properties. Furthermore, we used lead as chemical tool explore whether...