A5016997498- Neuroscience and Neuropharmacology Research
- Statistical Methods in Clinical Trials
- Statistical Methods and Inference
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Traditional Chinese Medicine Analysis
- Medical Imaging and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Natural Compounds in Disease Treatment
- Osteoarthritis Treatment and Mechanisms
- Nerve injury and regeneration
- Natural product bioactivities and synthesis
- Statistical Methods and Bayesian Inference
- Optimal Experimental Design Methods
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Ginkgo biloba and Cashew Applications
- Cholinesterase and Neurodegenerative Diseases
- Plant-based Medicinal Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Advanced Causal Inference Techniques
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience of respiration and sleep
- Biological and pharmacological studies of plants
Weatherford College
2022-2024
Stomatology Hospital
2023
Sun Yat-sen University
2023
Zhejiang Pharmaceutical College
2016-2022
Columbia University
2010-2020
Second Affiliated Hospital of Xi'an Jiaotong University
2006-2019
Wuhan University
2014-2018
Renmin Hospital of Wuhan University
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Wuhan Donghu University
2014
Basic fibroblast growth factor (bFGF) was recently found to modulate the outgrowth-regulating effects of glutamate, and protected neurons from several brain regions against excitotoxi/ischemic damage. We provide evidence that excitoprotective mechanism bFGF involves suppression expression a 71 kDa NMDA receptor protein (NMDARP- 71). NMDARP-71 mRNA levels were reduced in bFGF- treated hippocampal cell cultures. The not by NGF or epidermal factor, did reduce level for GluR1 kainate/AMPA...
Platelet-derived growth factors (PDGFs) and PDGF receptors are expressed in brain, where their functions largely unknown. We tested the hypothesis that PDGFs play a role promoting survival of neurons exposed to metabolic oxidative insults. Exposure rat mouse hippocampal cell cultures glucose-deficient medium or hydroxyl radical-promoting agent FeSO4 resulted progressive neuronal loss. Pretreatment with PDGF-AA PDGF-BB highly significant attenuation glucose deprivation- FeSO4-induced...
Tetramethylpyrazine (TMP) is one of the most important active ingredients a Chinese herb Ligusticum wallichii Franchat, which widely used in many ischemia disorders treatments. However, exact mechanism by TMP protects spinal cord ischemia/reperfusion (I/R) injury still unknown. For this purpose, rabbits were randomly divided into sham group, control group and group. After evaluation neurologic function, cords immediately removed for biochemical histopathological analysis. Apoptosis was...
Alzheimer’s disease (AD) patients suffer a disturbance in the balance between synaptic (GluN2A, mediating protective pathway) and extrasynaptic NMDA receptors (NMDARs) (GluN2B, excitotoxic pathway), and, therefore, restoring of GluN2A GluN2B should be beneficial for AD. In this study, GluN2B-selective antagonist, ifenprodil, non-selective NMDAR agonist, NMDA, had little effect on amyloid-β (Aβ)-induced long-term potentiation deficits. Enhancing activity against Aβ, specific activation...
The phenotypes of osteoarthritis (OA) consist cartilage extracellular matrix (ECM) metabolism disorder and the breakdown homeostasis, which are induced by pro-inflammatory factors oxidative stress. Selenoproteins regulated selenocysteine insertion sequence binding protein 2 (SBP2) highly effective antioxidants, but their regulatory mechanisms, particularly involvement miRNAs, not fully understood.To explore whether miR-181a-5p SBP2 involved in OA pathogenesis, we established an IL-1β model...
In acupuncture practice, the most important step is to confirm location of a sensitized acupoint which reflects diagnosis and can be stimulated with specialized needle treat disease. Abnormal symptoms such as hyperalgesia or allodynia at acupoints in patients visceral disorders are considered relation referred pain neurogenic inflammation. Yet, limited study has investigated cutaneous neurochemical changes acuponits.The resent developed an animal model gastric mucosal injury (GMI) by HCl...
The course of intracellular pH (pHi) was followed in superfused (36 degrees C) single glomus (type I) cells the freshly dissociated adult rat carotid body. had been loaded with pH-sensitive fluorescent dye 2',7'-(2-carboxyethyl)-5 (and -6)-carboxyfluorescein. high K(+)-nigericin method used for calibration. pHi cell at pHo 7.40, without CO2, 7.23 +/- 0.02 (n = 70); 5% CO2/25 mM HCO3-, 7.18 0.08 9). very sensitive to changes pHo. Without delta pHi/delta 0.85 (pHo 6.20-8.00; 32 cells), while...
Alzheimer's disease (AD) is a progressive neurodegenerative disease, and effective therapeutic drugs in the clinic are still lacking. Ideally, AD progression could be stopped at an early stage, such as mild cognitive impairment (MCI) stage. MCI refers to clinical condition between normal aging dementia. Patients with experience memory loss but do not meet criteria for diagnosis of clinically probable AD. However, few animal models have been established. Here, we used vivo long-term...
Osteoarthritis (OA) is a degenerative joint disease usually seen in the elderly, which incidence increases with age. Its pathogenesis and underlying mechanism are still unclear. The severely affects physical health life quality of patients, thereby constituting huge economic burden to family society. Luteolin (LUT) natural flavonoid multiple pharmacological properties. Many plants containing LUT have been applied treatment several inflammation-related diseases due relatively strong...
Abstract Medaka is an ideal model for sex determination and reversal, such as XY phenotypically female patients in humans. Here, we assembled improved TALENs targeting the DMY gene generated − mutants to investigate gonadal dysgenesis medaka. -TALENs resulted indel mutations at targeted loci (46.8%). DMY-nanos3UTR induced were passed through germline F1 generation with efficiencies of up 91.7%. developed into females, laid eggs stably Y chromosome next generation. RNA-seq 157 million raw...
Staurosporine, K-252a, and the 9-carboxylic related compound K-252b are low-molecular-weight alkaloids from microbial origin that at high concentrations kinase inhibitors can antagonize effects of neuronal growth factors. Paradoxically, we have found very low these agents (10 fM-10 nM) prolong survival hippocampal, septal, cortical neurons deprived glucose. These did not prevent depletion ATP caused by glucose deprivation. The large elevation intracellular calcium levels normally mediates...
Ebselen is an organoselenium compound that has demonstrated potent antioxidant and anti-inflammatory effects in previous studies. The present study was conducted to evaluate the effect of ebselen on myocardial ischemia-reperfusion (I/R) injury a rat model elucidate related mechanisms. Myocardial infarct size assessed using triphenyltetrazolium chloride staining. evaluated according histopathological ultrastructural alterations hearts serum activity levels cardiac enzymes, including creatine...
Previous studies have demonstrated the efficacy of electroacupuncture at ST36 for patients with gastrointestinal motility disorders. While several lines evidence suggest that effect may involve vagal reflex, precise molecular mechanism underlying this process still remains unclear. Here we report intragastric pressure increase induced by low frequency electric stimulation was blocked AP-5, an antagonist N-methyl-D-aspartate receptors (NMDARs). Indeed, stimulating enhanced NMDAR-mediated, but...
The aim of this study was to evaluate the effects different doses ginsenoside Rb1 (GRb1) pretreatment on spinal cord ischemia-reperfusion (SCII) in rats and explore potential mechanisms about expression survivin protein after intervention.A total 90 healthy adult Sprague-Dawley (SD) were randomly divided into six groups: sham-operated (n = 15), SCII model GRb1-treated groups 60). group four subgroups: 10 mg/kg, 20 40 80 mg/kg 15). corresponding dose GRb1 injected intraperitoneally 30 min...