A5017833909- Pregnancy and preeclampsia studies
- Marine Sponges and Natural Products
- Phytochemistry and Bioactive Compounds
- Phytochemical Studies and Bioactivities
- Prenatal Screening and Diagnostics
- Renal and related cancers
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Geology and Paleoclimatology Research
- Geochemistry and Elemental Analysis
- Complexity and Algorithms in Graphs
- Magnetic confinement fusion research
- Single-cell and spatial transcriptomics
- Game Theory and Voting Systems
- Protein Structure and Dynamics
- Pluripotent Stem Cells Research
- Aquaculture disease management and microbiota
- Ginseng Biological Effects and Applications
- Machine Learning in Bioinformatics
- MicroRNA in disease regulation
- Invertebrate Immune Response Mechanisms
- Herbal Medicine Research Studies
- Computational Drug Discovery Methods
Beijing Institute of Big Data Research
2025
Beijing Jiaotong University
2025
Institute of Zoology
2018-2024
Chinese Academy of Sciences
2004-2024
University of Chinese Academy of Sciences
2019-2024
Center for Excellence in Molecular Cell Science
2004-2024
Ningbo No. 2 Hospital
2024
Harvard University
2024
Northeast Normal University
2024
Guangzhou Institute of Geochemistry
2023-2024
The placenta is one of the most important yet least understood organs. Due to limitations conventional research approaches, we are still far from a comprehensive understanding mouse placentation, especially regarding differentiation trophoblast lineages at early developmental stage. To decipher cell compositions and processes, systematically profile single-cell transcriptomes cells extraembryonic tissues (embryonic day 7.5 (E7.5) E8.5) placentae (E9.5-E14.5) one-day intervals. We identify...
The management of the interface between wound microenvironment and skin substitute (SSS) is fundamental to repair an important factor in regeneration damaged tissue. Current biomaterials result unideal effect defective tissue due limited early exudate inability respond positively endogenous growth factors. Based on a refined electrospinning process, polycaprolactone fiber - alginate hydrogel interpenetrated network scaffold subsequent multifunctional modifications serving as SSS was...
Zika virus (ZIKV) infection during pregnancy threatens and fetal health. However, the infectivity pathological effects of ZIKV on placental trophoblast progenitor cells in early human embryos remain largely unknown. Here, using stem (hTSCs), we demonstrated that hTSCs were permissive to infection, resistance increased with hTSC differentiation. Combining gene knockout transcriptome analysis, intrinsic expression AXL TIM-1, absence potent interferon (IFN)-stimulated genes (ISGs) IFNs...
Abstract Here, we delineated the remarkably elevated neuroinflammation accompanied by progressive activation of double-stranded RNA (dsRNA)-activated Protein Kinase R (PKR) and PKR-related dsRNA pathways in hippocampus 5×FAD mice upon Alzheimer’s disease (AD) progression. AAV-delivery circular RNAs possessing short-imperfect duplex regions (ds-cRNAs) to neurons microglia effectively dampened excessive PKR activity with little toxicity, accompanying reduced amyloid-beta (Aβ) plaques,...
A protocol for high intermediate precision Sm isotope measurements.
Despite the importance of innate immunity in invertebrates, diversity and function immune cells invertebrates are largely unknown. Using single-cell RNA-seq, we identified prohemocytes, monocytic hemocytes, granulocytes as three major cell-types white shrimp hemolymph. Our results a novel macrophage-like subset called hemocytes 2 (MH2) defined by expression certain marker genes, including Nlrp3 Casp1. This subtype is phagocytic expresses markers that indicate some conservation with mammalian...
In recent years, EAST has achieved a 60-s scale steady-state plasma operation (SSO), which is electron dominant heated by the cyclotron wave and low hybrid wave. Substantial progresses have been made in development of long-pulse operation, such as active control radiative divertor, edge localized mode (ELM) suppression, He experiment. To further develop scenario study related critical physical issues, upgrade completed 2020. The auxiliary heating systems were rearranged upgraded with total...
An aldol condensation is the key to eight-step linear synthesis of 23-oxa analogues OSW-1 (e.g. 2) in more than 20 % overall yield from industrially produced steroid 1. Compound 2 up 2000 times potent cisplatin as an inhibitor tumor cell growth. Supporting information for this article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z54237_s.pdf or author. Please note: The publisher not responsible content functionality any supporting supplied by authors. Any queries...
Recent studies have shown the presence of SARS-CoV-2 in tissues clinically recovered patients and persistent immune symptoms discharged for up to several months. Pregnant were be a high-risk group COVID-19. Based on these findings, we assessed nucleic acid protein retention placentas pregnant women who had fully from COVID-19 cytokine fluctuations maternal foetal tissues.Remnant term placenta was detected using amplification immunohistochemical staining protein. The infiltration CD14+...
Upon implantation, the trophectoderm differentiates into multi-nucleated primitive syncytiotrophoblast (pSTB) through a process called primary syncytialization to facilitate maternal-fetal interactions and establish pregnancy. However, ethical issues limited access human embryos around time of embryo implantation hinder investigation detailed molecular mechanisms underpinning this event in humans. Here we established trophoblast stem cells (hTSCs) from blastocysts. We characterized nuclear...
Abstract Schizophrenia (SZ) is a complex disabling disorder that leads to the mental disability and afflicts 1% of world's total population placed in top ten medical disorders. In current work, bioinformatics analyses were carried out on Trace amine (TA)‐associated receptor 6 (TAAR6) recognize potential drugs compounds against SZ. Comparative modeling threading‐based approaches utilized for structure prediction TAAR6. Fifty‐nine predicted structures evaluated by various model assessment...
The aim of this study was to evaluate the effects different doses ginsenoside Rb1 (GRb1) pretreatment on spinal cord ischemia-reperfusion (SCII) in rats and explore potential mechanisms about expression survivin protein after intervention.A total 90 healthy adult Sprague-Dawley (SD) were randomly divided into six groups: sham-operated (n = 15), SCII model GRb1-treated groups 60). group four subgroups: 10 mg/kg, 20 40 80 mg/kg 15). corresponding dose GRb1 injected intraperitoneally 30 min...
Sequence-based protein tertiary structure prediction is of fundamental importance because the function a ultimately depends on its 3D structure. An accurate residue-residue contact map one essential elements for current ab initio protocols prediction. Recently, with combination deep learning and direct coupling techniques, performance residue has achieved significant progress. However, considerable number Deep-Learning (DL)-based methods are usually time-consuming, mainly they rely different...
Implantation of the human blastocyst is a milestone event in embryonic development. The trophoblast first cell lineage to differentiate during implantation. Failures differentiation implantation are correlated defects pregnancy and growth. However, many gaps remain knowledge development, especially regarding morphogenesis function. Herein, we performed single-cell RNA sequencing (scRNA-seq) analysis on post-implantation embryos cultured vitro. A hierarchical model was established, which...
Abstract The embryo‐like structures (embryoids) constructed by aggregating embryonic stem cells (ESCs) and trophoblast (TSCs) have provided revolutionary tools for studying the intricate interaction between extra‐embryonic tissues during early development, which has been achieved in mice. However, due to opposite dependence on some signalling pathways vitro culture of human ESCs (hESCs) TSCs (hTSCs), particularly WNT TGFβ pathways, limits construction post‐implantation embryoids hESCs hTSCs....
Ginsenosides, the primary medicinally active substances in ginseng, are consistently used to treat a variety of diseases. Cultivated ginseng was domesticated from wild for which mode domestication and changes content ginsenosides their regulatory mechanisms during process were unclear. Here, transcriptome sequencing metabolomic analysis compare cultivated ginsengs gain insight into genetic associated with domestication. Genetic structure revealed that might have undergone independent China...
Aberrant activation of the Hedgehog (HH) signaling pathway underlines initiation and progression a multitude cancers. The effectiveness leading drugs vismodegib (GDC-0449) sonidegib (LDE225), both Smoothened (SMO) antagonists, is compromised by acquisition mutations that alter components, notably secondary in SMO amplification GLI2, transcriptional mediator at end pathway. Pharmacologic blockade GLI2 activity could ultimately overcome these diversified refractory mechanisms, which would also...
The automatic detection of cells in microscopy image sequences is a significant task biomedical research. However, routine images with cells, which are taken during the process whereby constant division and differentiation occur, notoriously difficult to detect due changes their appearance number. Recently, convolutional neural network (CNN)-based methods have made progress cell tracking. these approaches require many manually annotated data for fully supervised training, time-consuming...