A5003448775- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Immune Cell Function and Interaction
- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- Studies on Chitinases and Chitosanases
Shantou University
2022
Despite the importance of innate immunity in invertebrates, diversity and function immune cells invertebrates are largely unknown. Using single-cell RNA-seq, we identified prohemocytes, monocytic hemocytes, granulocytes as three major cell-types white shrimp hemolymph. Our results a novel macrophage-like subset called hemocytes 2 (MH2) defined by expression certain marker genes, including Nlrp3 Casp1. This subtype is phagocytic expresses markers that indicate some conservation with mammalian...
Abstract For a long time, how anti-inflammatory factors evolved was largely unknown. In this study, we chose marine invertebrate, Litopenaeus vannamei, as model and identified that shrimp mesencephalic astrocyte-derived neurotrophic factor (MANF) an LPS-induced plasma protein, which exerted its roles on hemocytes by suppressing ERK phosphorylation Dorsal expression. addition, demonstrated MANF could be associated with receptor protein tyrosine phosphatase (RPTP) to mediate negative...