A5028949606- Oral microbiology and periodontitis research
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Immune Response and Inflammation
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Electrospun Nanofibers in Biomedical Applications
- Diabetes and associated disorders
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Bone and Dental Protein Studies
- dental development and anomalies
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Tissue Engineering and Regenerative Medicine
- Endodontics and Root Canal Treatments
- Head and Neck Cancer Studies
- Autophagy in Disease and Therapy
- Digestive system and related health
- Silk-based biomaterials and applications
- Lipid metabolism and disorders
- Sexual function and dysfunction studies
- Antimicrobial Peptides and Activities
Stomatology Hospital
2019-2025
Sun Yat-sen University
2014-2025
Capital Medical University
2022-2025
Beijing Friendship Hospital
2022-2025
Hospital of Stomatology, Sun Yat-sen University
2019-2025
National Clinical Research Center for Digestive Diseases
2023
Beijing Obstetrics and Gynecology Hospital
2023
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2021
Sun Yat-sen Memorial Hospital
2017
Harvard University Press
2010
Periodontitis is caused by host immune-inflammatory response to bacterial insult. A high proportion of pro-inflammatory macrophages anti-inflammatory leads the pathogenesis periodontitis. As stem cell-derived exosomes can modulate macrophage phenotype, dental pulp (DPSC-Exo) effectively treat In this study, we demonstrated that DPSC-Exo-incorporated chitosan hydrogel (DPSC-Exo/CS) accelerate healing alveolar bone and periodontal epithelium in mice with Gene Ontology (GO) term enrichment...
Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and limited efficacy, hampered clinical application. These drawbacks can be largely reduced by replacing the traditional 2D culture system with a 3D system. However, potential function of MSC-exos produced (3D-exos) periodontitis remains elusive. This study showed that compared generated via (2D-exos), 3D-exos enhanced...
Exosomes are important mediators of intercellular communication and have a vital part in the diagnosis treatment various diseases humans. Here, we investigated benefits underlying mechanism exosomes secreted via stem cells from human exfoliated deciduous teeth (SHED-derived exosomes) promoting alveolar bone regeneration, thus providing new insights into exosome-based therapy for periodontitis. SHED-derived were isolated by ultracentrifugation. The impacts on angiogenic ability umbilical vein...
Periodontitis is initiated by the infection of periodontal bacteria and subsequent tissue inflammation due to immunoreaction, eventually leading apparatus loss. Stem cells from human exfoliated deciduous teeth (SHEDs) have exhibited beneficial characteristics in dental regeneration. However, immunomodulatory functions SHEDs not been elucidated context periodontitis treatment. In this study, we investigated potential effects on experimental demonstrated that multidose delivery led...
Abstract Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related DP. Moreover, inhibition oral administration bindarit reduced alveolar bone loss increased epithelial thickness...
Apical periodontitis (AP) is an infectious disease that causes periapical tissue inflammation and bone destruction. Ferroptosis, a novel type of regulated cell death, closely associated with inflammatory diseases the regulation homeostasis. However, exact involvement ferroptosis in loss AP not fully understood. In this study, human tissues were collected, mouse model was established to investigate role AP. Colocalization staining revealed macrophages contributes A constructed using RAW 264.7...
Abstract The consumption of a high-fat diet (HFD) has been linked to osteoporosis and an increased risk fragility fractures. However, the specific mechanisms HFD-induced are not fully understood. Our study shows that exposure HFD induces premature senescence in bone marrow mesenchymal stem cells (BMSCs), diminishing their proliferation osteogenic capability, thereby contributes osteoporosis. Transcriptomic chromatin accessibility analyses revealed decreased vitamin D receptor (VDR)-binding...
Abstract Aim Clinical and in vitro evidence indicates that chronic inflammatory responses initiated by dental caries can persist the pulp even after treatment, necessitating formation of reparative dentin to restore tissue homeostasis health. Human stem cells (hDPSCs) serve as crucial precursors this process. This study explores role B their secreted factor, Angiopoietin Like 1 (ANGPTL1), promoting hDPSCs differentiation into odontoblasts under carious conditions, with a particular focus on...
Abstract Pathogenesis of periodontitis is marked by microbiota dysbiosis and disrupted host responses. Porphyromonas gingivalis a keystone pathogen which expresses various crucial virulence factors. This study aimed to clarify the role mechanisms P. tryptophan-indole metabolic pathway in pathogenesis periodontitis. showed that patients exhibited elevated tryptophan metabolism salivary abundance. Tryptophanase gene-deficiency altered proteome metabolome , inhibited virulent factors...
Periodontitis leads to the degradation of tooth-supporting tissues, ultimately causing tooth mobility and loss. Guided tissue regeneration (GTR) surgery employs barrier membranes facilitate regeneration. However, conventional lack bone-inducing properties, thereby limiting their efficacy. Our objective was develop a bifunctional GTR membrane that combines mechanical stability with capabilities. To achieve this, we engineered BMP2 peptide-modified polycaprolactone-collagen nanosheets (BPCNs)...
The mandible, also known as the lower jaw, is only bone in skull that can move and essential for speaking chewing. Meckel’s cartilage (MC) a temporary structure supports formation of but how MC involved ossification mandible poorly understood. Through use single-cell RNA sequencing spatial transcriptomics analyses, spatiotemporal atlas human fetuses from 7 to 15 wk postconception was established, highlighting role mandible. Importantly, we revealed two populations contributed mandibular...
Radiation-induced oral mucositis affects patient quality of life and reduces tolerance to cancer therapy. Unfortunately, traditional treatments are insufficient for the treatment might elicit severe side effects. Due their immunomodulatory anti-inflammatory properties, transplantation mesenchymal stem cells (MSCs) is a potential therapeutic strategy mucositis. However, systemically infused MSCs rarely reach inflamed sites, impacting clinical efficacy. Previous studies have demonstrated that...
Objectives: To compare the sealing ability and biocompatibility of Biodentine with mineral trioxide aggregate (MTA) when used as root-end filling materials. Methodology: The Cell Counting Kit-8 (CCK-8) assay was to cytotoxicity MTA Biodentine. Twenty-one extracted teeth a single canal were immersed in an acidic silver nitrate solution after filling. Then, volume depth that infiltrated apical portion analyzed using micro-computed tomography (micro-CT). Seventy-two roots from 3 female beagle...
The severe pain caused by oral ulcers seriously affects food intake and speech, bringing great inconvenience in daily life. Drug-loaded patches are mostly used to treat mucosal diseases such as lichen planus, but their effects limited because of the influences saliva muscle movement. To enhance adhesion drug-loaded cavity, we designed antimicrobial peptides (AMPs)-modified polycaprolactone (PCL)-collagen nanosheets (APCNs). internal layer is a bioactive antibacterial collagen modified with...
Melatonin has been reported to improve nonalcoholic fatty liver disease (NAFLD), and exploring the underlying mechanisms will be beneficial for better treatment of NAFLD. Choline-deficient high-fat diet (CDHFD)- methionine/choline-deficient (MCD)-fed mice with melatonin intervention exhibit significantly decreased steatosis, lobular inflammation, focal necrosis. Single-cell RNA sequencing reveals that selectively inhibits pro-inflammatory CCR3+ monocyte-derived macrophages (MoMFs)...
Based on the selective area growth (SAG) technique, an enhancement mode GaN recessed gate MOSFET was fabricated successfully with negligible trapping effect, presenting extremely small threshold voltage (Vth) hysteresis of 50 mV at a bias swing up to 10 V. Compared larger Vth by dry-etching, correlation between and lattice damage related traps caused plasma dry etching process has been confirmed. Furthermore, SAG shows lower turn-ON resistance due higher MOS channel mobility. We believe that...