A5002189314- Inflammatory Bowel Disease
- Mesenchymal stem cell research
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- Pain Mechanisms and Treatments
- Endodontics and Root Canal Treatments
- Oral microbiology and periodontitis research
- Antimicrobial Peptides and Activities
- Hippo pathway signaling and YAP/TAZ
- Phytochemical Studies and Bioactivities
- Anesthesia and Neurotoxicity Research
- Lipid metabolism and disorders
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Tumors and Oncological Cases
- Hydrogen's biological and therapeutic effects
- Protein Hydrolysis and Bioactive Peptides
- TGF-β signaling in diseases
- Proteoglycans and glycosaminoglycans research
- Image and Object Detection Techniques
- 3D Shape Modeling and Analysis
- Immunotherapy and Immune Responses
- Human Motion and Animation
- Wnt/β-catenin signaling in development and cancer
Stomatology Hospital
2021-2025
Sun Yat-sen University
2021-2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Zunyi Medical University
2021-2022
Army Medical University
2021-2022
Chongqing Medical University
2022
Second Affiliated Hospital of Chongqing Medical University
2022
Dalian Medical University
2022
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2021
Xinqiao Hospital
2021
Abstract Background Well-balanced interactions between gut microbiota and the immune system are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). Toll-like receptor 4 (TLR4) functions a sensor mediating crosstalk commensal microbiome host immunity, but influence of TLR4 on shaping responses during colon inflammation remains poorly characterized. We investigated whether different susceptibilities colitis wild-type (WT) −/− mice were...
Abstract Nonalcoholic steatohepatitis (NASH) has been linked with the gut-liver axis. Here, we investigate potential for repurposing disulfiram (DSF), a drug commonly used to treat chronic alcoholism, NASH. Using mouse model, show that DSF ameliorates NASH in gut microbiota-dependent manner. modulates microbiota and directly inhibits growth of Clostridium . Administration abolishes ameliorating effects on Mechanistically, reduces -mediated 7α-dehydroxylation activity suppress secondary bile...
Chronic gastritis caused by Helicobacter pylori ( H. ) infection has been widely recognized as the most important risk factor for gastric cancer. Analysis of interaction between key participants in mucosal immunity and is expected to provide insights treatment chronic prevention Heparanase an endoglycosidase that degrades heparan sulfate, resulting remodeling extracellular matrix thereby facilitating extravasation migration immune cells towards sites inflammation. also releases sulfate-bound...
Abstract Aim Clinical and in vitro evidence indicates that chronic inflammatory responses initiated by dental caries can persist the pulp even after treatment, necessitating formation of reparative dentin to restore tissue homeostasis health. Human stem cells (hDPSCs) serve as crucial precursors this process. This study explores role B their secreted factor, Angiopoietin Like 1 (ANGPTL1), promoting hDPSCs differentiation into odontoblasts under carious conditions, with a particular focus on...
Rationale: Pain and depression, which tend to occur simultaneously share some common neural circuits neurotransmitters, are highly prevalent complication in patients with advanced cancer.Exploring the underlying mechanisms is cornerstone prevent comorbidity of chronic pain depression cancer patients.Plasticity-related gene 1 (PRG-1) protein regulates synaptic plasticity brain functional reorganization during neuronal development or after cerebral lesion.Purinergic P2X7 receptor has been...
Novel ecological antimicrobial approaches to dental caries focus on inhibiting cariogenic pathogens while enhancing the growth of health-associated commensal communities or suppressing virulence without affecting diversity oral microbiota, which emphasize crucial role establishing a healthy microbiome in prevention. Considering that acidified microenvironment leads dysbiosis microecology and demineralization enamel, exploiting acidic pH as bioresponsive trigger help materials medications...
Abstract Background Intestinal barrier dysfunction plays a central role in the pathological onset of Crohn’s disease. We identify cadherin superfamily member protocadherin 20 (PCDH20) as crucial factor Here we describe function PCDH20 and its mechanisms gut homeostasis, integrity, disease development. Results mRNA protein expression is significantly downregulated colonic epithelium patients mice with induced colitis compared controls. In mice, intestinal-specific Pcdh20 knockout causes...
Abstract Mucus injury associated with goblet cell (GC) depletion constitutes an early event in inflammatory bowel disease (IBD). Using single-cell sequencing to detect critical events mucus dysfunction, we discover that the Kazal-type serine protease inhibitor SPINK4 is dynamically regulated colitic intestine parallel activities. Under chemically induced conditions, grim status Spink4 -conditional knockout mice successfully rescued by recombinant murine SPINK4. Notably, its therapeutic...
Abstract Stanniocalcin‐1 (STC1) is upregulated by inflammation and modulates oxidative stress‐induced cell death. Herein, the function of STC1 in colitis parthanatos, a newly identified type programmed necrotic death dependent on activation poly‐ADP ribose polymerase‐1 (PARP1) investigated. Results show that expression markedly increased inflamed colonic mucosa Crohn's disease (CD) patients chemically‐induced mice models. Evaluation parthanatos severity pro‐inflammatory cytokine shows...
Regenerative endodontic therapy is a promising approach to restore the vitality of necrotic teeth, however, pulp regeneration in mature permanent teeth remains substantial challenge due insufficient developmental signals. The dentin embryologically and histologically similar pulp, which contains cocktail pulp-specific structural proteins growth factors, thus we proposed an optimizing strategy obtain matrix extracted (DMEP) engineered DMEP functionalized double network hydrogel, whose...
Neonatal repetitive noxious stimuli (RNS) has been shown to cause long-term harmful effects on nociceptive processing, learning, and memory which persist until adulthood. Plasticity-related gene 1 (PRG-1) regulates synaptic plasticity functional reorganization in the brain during neuronal development. In this study, neonatal RNS rats were established by needle pricks all four feet model pain exposure infants. caused thermal hyperalgesia, mechanical allodynia, impairments manifested young...
Background: Treatment failures (TFs) generally exist in the course of ulcerative colitis (UC), while early reliable predictors TFs are still lacking.We aimed to generate nomograms for prediction TFs.Methods: In this retrospective case-control study, endpoint was occurrence TFs, which included medically associated treatment and surgery-associated (colectomy).Clinical features mucus integrity evident by goblet cells (GCs) number, expression levels MUC2 SLC26A3 were enrolled univariate...
Abstract Human dental pulp stem cells (hDPSCs) play a vital role in the regeneration of pulp-dentin complex after disease. While efficiency relies on odontoblastic differentiation capacity hDPSCs, this is difficult to regulate within cavity. Although nicotinamide riboside (NR) has been found promote tissue regeneration, its specific not fully understood. Here, we aimed explore NR hDPSCs and underlying molecular mechanism. It was that enhanced viability retarded senescence with higher...