A5100657243- Inflammatory Bowel Disease
- Meteorological Phenomena and Simulations
- Precipitation Measurement and Analysis
- Soil Moisture and Remote Sensing
- Helicobacter pylori-related gastroenterology studies
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Barrier Structure and Function Studies
- Gut microbiota and health
- Ubiquitin and proteasome pathways
- Microscopic Colitis
- Wnt/β-catenin signaling in development and cancer
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- Congenital gastrointestinal and neural anomalies
- TGF-β signaling in diseases
- Circular RNAs in diseases
- Educational Reforms and Innovations
- Neonatal and fetal brain pathology
- Hedgehog Signaling Pathway Studies
- Maternal Mental Health During Pregnancy and Postpartum
North China University of Water Resources and Electric Power
2025
Sun Yat-sen University
2009-2024
Shandong University of Traditional Chinese Medicine
2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
The First Affiliated Hospital, Sun Yat-sen University
2019-2024
China Geological Survey
2024
Hainan Meteorology Administration
2023
Shanghai Jiao Tong University
2021
Shanghai First People's Hospital
2021
Hainan Meteorological Service
2021
The repressor element 1 (RE1) silencing transcription factor (REST) helps preserve the identity of nervous tissue by neuronal genes in non-neural tissues. Moreover, an epithelial model tumorigenesis, loss REST function is associated with adhesion, suggesting aberrant expression REST-controlled encoding this property. To date, no adhesion molecules under control have been identified. Here, we used serial analysis chromatin occupancy to perform genome-wide identification REST-occupied target...
Magnitude and diversity of gut microbiota metabolic systems are critical in shaping human health diseases, but it remains largely unclear how complex metabolites may selectively regulate determine diseases. Here, we show that failures or compromised effects anti-TNF-α therapy inflammatory bowel diseases (IBD) patients were correlated with intestinal dysbacteriosis more pro-inflammatory bacteria, extensive unresolved inflammation, failed mucosal repairment, aberrant lipid metabolism,...
Intestinal homeostasis disorder is critical for developing Crohn's disease [CD]. Maintaining mucosal barrier integrity essential intestinal homeostasis, preventing injury and complications. Among the remarkably altered long non-coding RNAs [lncRNAs] in CD, we aimed to investigate whether metastasis-associated lung adenocarcinoma transcript 1 [MALAT1] modulated CD consequent disruption of homeostasis.Microarray analyses on mucosa patients controls were performed identify dysregulated lncRNAs....
Hyperspectral image classification (HSIC) represents a significant area of research within the domain remote sensing. Given intricate nature hyperspectral images and substantial volume data they generate, it is essential to introduce innovative methodologies effectively address pre-processing challenges encountered in HSIC. In this paper, we draw inspiration from Segment Anything Model (SAM) realm large language models propose its application for HSIC, aiming achieve advancements...
Abstract Background Intestinal barrier dysfunction plays a central role in the pathological onset of Crohn’s disease. We identify cadherin superfamily member protocadherin 20 (PCDH20) as crucial factor Here we describe function PCDH20 and its mechanisms gut homeostasis, integrity, disease development. Results mRNA protein expression is significantly downregulated colonic epithelium patients mice with induced colitis compared controls. In mice, intestinal-specific Pcdh20 knockout causes...
Abstract Mucus injury associated with goblet cell (GC) depletion constitutes an early event in inflammatory bowel disease (IBD). Using single-cell sequencing to detect critical events mucus dysfunction, we discover that the Kazal-type serine protease inhibitor SPINK4 is dynamically regulated colitic intestine parallel activities. Under chemically induced conditions, grim status Spink4 -conditional knockout mice successfully rescued by recombinant murine SPINK4. Notably, its therapeutic...
Reflectivity factor bias caused by radar calibration errors would influence the accuracy of Quantitative Precipitation Estimations (QPE), and further result in spatial discontinuity Multiple Ground Radars QPE (MGR-QPE) products. Due to sampling differences random errors, associated cannot be thoroughly solved single-radar method. Thus, a multiple-radar synchronous approach was proposed mitigate MGR-QPE. Firstly, intercalibration adjacent ground radars, then were reduced referring Ku-Band...
The Precipitation Radar (PR) on the Tropical Rainfall Measuring Mission satellite has already provided reliable observations for more than 15 years. There is a potential possibility to assess long-term data of ground-based radar (GR) in China new generation weather network through comparison between PR and GR. In this letter, stratiform precipitation above below bright bands used implement reflectivity Nanjing from 2003 2014. results show that accuracy GR well correlated with distance GR,...
The LuTan-1 (LT-1) satellite, launched in 2022, is China’s first L-band full-polarimetric Synthetic Aperture Radar (SAR) constellation, boasting interferometry capabilities. However, given its limited use subsidence monitoring to date, a comprehensive evaluation of LT-1’s interferometric quality and capabilities necessary. In this study, we utilized the Differential Interferometric (DInSAR) technique analyze mining-induced results near Shenmu City (China) with LT-1 data, revealing nine areas...
The function of H3F3A G43W mutation, which has been observed in almost all GCTB, remains poorly characterized. Breakthrough malignant GCTB trapped by the lack clinical available drugs, limited canonical patient samples and paucity fidelity preclinical models.Tumor obtained from a was implanted immunodeficient mice for generation PDX. Histological examination short tandem repeat (STR) were used inherited features analyses. An epigenetic/transcriptional targeted compound library selected drug...
ABSTRACT Calibration error, due to ground‐based radar ( GR ) hardware parameters, introduces biases reflectivity factor data. As a result of this, observations from the China new‐generation weather network have sometimes been found be inconsistent, even when observing precipitation in same area. In this paper method, called Available Best Comparable Data set ABCD is proposed. The method evaluates bias datasets by using TRMM S tandard Product TSP 2A25 data Tropical Rainfall Measuring Mission...
Cinrad is the acronym describing China's next-generation weather radar that inherits technology of US national system Nexrad (WSR-88D) through a joint agreement between two countries. More than 100 systems have currently been deployed in China, but challenges exist for their wider application. The data quality assessment and development quantitative precipitation estimation flood risk management will pose significant challenge as both commissioned further developed. This paper based on an...
Background and Aims: Elevated fecal calprotectin (FC) levels have been reported to correlate with histological activity in patients ulcerative colitis (UC). However, the accuracy of FC for evaluating UC remains be determined. The aim this study was determine UC, based on updated definitions. Methods: Related studies were retrieved from PubMed, Web Science, Embase, Cochrane databases. Adult participants diagnosed included when sufficient data could extracted calculate activity. primary...
Based on the Dynamical–Statistical–Analog Ensemble Forecast model for Landfalling Typhoon Precipitation (DSAEF_LTP model), optimal forecast scheme tropical cyclone (TC) accumulated precipitation over Hainan Island, China (DSAEF_LTP_HN) is established. To test forecasting performance of DSAEF_LTP_HN, its results are compared with other numerical models. The average threat score (TS) by DSAEF_LTP_HN models independent samples. show that ≥100 mm, TS produced reaches 0.39, ranking first,...