A5086364421- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Head and Neck Surgical Oncology
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Facial Trauma and Fracture Management
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Facial Nerve Paralysis Treatment and Research
- Bone health and treatments
- Reconstructive Facial Surgery Techniques
- Tissue Engineering and Regenerative Medicine
- Dental Implant Techniques and Outcomes
- interferon and immune responses
- Biochemical effects in animals
- Cell death mechanisms and regulation
- Salivary Gland Disorders and Functions
- Periodontal Regeneration and Treatments
- Oral and Maxillofacial Pathology
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Gut microbiota and health
- Voice and Speech Disorders
Stomatology Hospital
2014-2025
Sun Yat-sen University
2016-2025
Hospital of Stomatology, Sun Yat-sen University
2014-2022
Key Laboratory of Guangdong Province
2020
Fifth Affiliated Hospital of Sun Yat-sen University
2017
Cancer-associated fibroblasts (CAFs) play an important role in regulating tumor progression by transferring exosomes to neighboring cells. Our aim was clarify the of microRNA encapsulated derived from CAFs oral squamous cell carcinoma (OSCC).We examined expression profiles and donor-matched normal (NFs) patients with OSCC. We used confocal microscopy examine transportation exosomal miR-34a-5p between OSCC Next, luciferase reporter its mutant plasmids were confirm direct target gene...
Bisphosphonates related osteonecrosis of jaw (BRONJ) is a severe complication systemic BPs administration, the mechanism which still unclarified. Recently, platelet-derived growth factor-BB (PDGF-BB) secreted by preosteoclasts was reported to promote angiogenesis and osteogenesis. This study aimed clarify whether bisphosphonates suppressed releasing PDGF-BB, suppression harmed coupling osteogenesis, could contribute BRONJ manifestation.Zoledronate significantly inhibited osteoclast formation...
Magnitude and diversity of gut microbiota metabolic systems are critical in shaping human health diseases, but it remains largely unclear how complex metabolites may selectively regulate determine diseases. Here, we show that failures or compromised effects anti-TNF-α therapy inflammatory bowel diseases (IBD) patients were correlated with intestinal dysbacteriosis more pro-inflammatory bacteria, extensive unresolved inflammation, failed mucosal repairment, aberrant lipid metabolism,...
Necroptosis is a recently discovered form of programmed cell death (PCD) having necrotic-like morphology. However, its presence and potential impact with respect to head neck squamous carcinoma (HNSCC) are still unknown. The aim this study was reveal the necroptosis status clinicopathological relevance in HNSCC establish an vitro model. We first analyzed level p-MLKL, MLKL, tumor necrosis patient tissues as well their correlation features. Results showed that approximately half can be...
Abstract Cancer-associated fibroblasts (CAFs) are abundant and heterogeneous in tumor microenvironment (TME). Cross-talk between cancer cells CAFs results progression. Here, we demonstrated that a distinct cancer-associated subset with podoplanin (PDPN) positive expression (PDPN + CAFs) was correlated poor survival oral squamous cell carcinoma (OSCC). PDPN promoted the progression of OSCC by transferring exosomal lncRNA FTX to cells. Mechanically, bound flap endonuclease-1 (FEN1), forming an...
Background The process of marsupialization involves the release intracystic pressure and fluid contained within. Marsupialization cystic ameloblastoma is controversial; therefore, we investigated how hydrostatic influences biological behaviours cells its underlying mechanisms. Materials Methods An epithelial cell line, hTERT + ‐AM, was exposed to different pressures with or without Dickkopf‐related protein 1 (also known as DKK), a canonical Wnt signalling pathway inhibitor. A CCK‐8 assay,...
Chronic hepatitis B virus (HBV) infection poses a significant global public health challenge and is found closely related to extrahepatic cancers, including head neck cancer. Oral squamous cell carcinoma (OSCC) the major category of This retrospective study was conducted explore clinical correlation survival analysis OSCC patients with HBV. The involved 1,373 treated at Hospital Stomatology, Sun Yat-sen University from 2012 2022. Propensity score matching used analyze correlations outcomes,...
Abstract Background This retrospective study investigated the reduction rate and speed of shrinkage after marsupialization in mandibular cystic ameloblastoma clarified whether is appropriate for unicystic multicystic ameloblastoma. Methods Sixty‐three patients with were initially treated marsupialization. Premarsupialization postmarsupialization panoramic radiographs reviewed shrinkage, then evaluated age, sex, tumor location, type. Results The overall recurrence was 4.5% (2/44). average...
This study aimed to assess the functional and esthetic outcomes of a chimeric innervated buccinator myomucosal-submental island flap (BMM-SIF) for large composite lower lip reconstruction.
Abstract Background The relationship between cancer and coagulation has been intensively studied in recent years; however, the effects of factors on oral squamous cell carcinoma (OSCC) have rarely reported. This study aimed to investigate preoperative D-dimer (DD), fibrinogen (FIB), platelets (PLT) OSCC, as well prognostic value DD, FIB PLT OSCC. Methods We retrospectively investigated a total 202 patients with OSCC treated at Guanghua Hospital Stomatology, Sun Yat-sen University. Baseline...
BackgroundFOXO3a has been widely regarded as a tumor suppressor. It also plays paradoxical role in regulating the cancer stem cells (CSCs), responsible for tumor-initiation, chemo-resistance, and recurrence various solid tumors, including oral squamous cell carcinoma (OSCC). This study aims to uncover of FOXO3a its importance non-canonical pathway TGFβ OSCC stemness.MethodsWe identified expression tissues lines using immunohistochemistry western blot. The correlation between stemness was...
Abstract CA9 is a member of the carbonic anhydrases’ family, that often expressed in cancer cells under hypoxic condition. However, role molecular mechanisms tongue squamous cell carcinoma (TSCC) pathogenesis remains unclear. expression was analysed using TCGA database, and its influence on survival performed Kaplan‐Meier, LASSO COX regression analyses. The correlation between immune infiltration investigated by CIBERSORT ESTIMATE. Moreover, relationship downstream regulation pathways GSEA,...
Abstract Background Cancer cells frequently evolve necroptotic resistance to overcome various survival stress during tumorigenesis. However, we have previously showed that necroptosis is widespread in head and neck squamous cell carcinoma (HNSCC) contributes tumor progression poor via DAMPs-induced migration invasiveness peri-necroptotic cells. This implicated an alternative strategy cancers cope with by reprogramming a pro-invasive microenvironment (NME). Here, aim decipher how shape the...
Abstract Objective: The management of early-stage (cT1/2N0) oral squamous cell carcinoma (OSCC) remains a controversial issue. aim this study was to compare the clinical outcomes neck observation (OBS) and elective dissection (END) in treating patients with cT1/2N0 OSCC. Methods: A total 232 OSCC were included retrospective study. Of these patients, 181 treated END 51 OBS. survival curves 5-year overall (OS), disease-specific (DSS), recurrence-free (RFS) rates plotted using Kaplan-Meier...
Cancer-associated fibroblasts (CAFs) play an important role in regulating tumor progression by subverting the microenvironment. CAFs secrete soluble molecules and various extracellular vesicles, including exosomes, to communicate with cells. However, specific roles of exosomes secreted microenvironment are unclear. In present study, we performed microRNA (miRNA) sequencing derived from matched normal (NFs) patients oral squamous cell carcinoma (OSCC). We observed a significant reduction...