A5101931517- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Hedgehog Signaling Pathway Studies
- RNA modifications and cancer
- Oral and Maxillofacial Pathology
- Animal Behavior and Reproduction
- Fibroblast Growth Factor Research
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Sirtuins and Resveratrol in Medicine
- TGF-β signaling in diseases
- Animal Vocal Communication and Behavior
- Mesenchymal stem cell research
- Plant and animal studies
- Endodontics and Root Canal Treatments
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Kruppel-like factors research
Stomatology Hospital
2023-2024
Sun Yat-sen University
2016-2023
Estrogenic metabolites of circulating androgens have important effects on the organization and activation neural circuits controlling reproductive behavior physiology in males many vertebrate species. Previous studies indicate that aromatase, enzyme converts to estrogens, is expressed most abundantly neurons limbic brain regions. Songbirds are unique aromatase at unusually high levels throughout telencephalon both females. We assume estrogens formed itself masculinize song, since a major...
Abstract Cancer-associated fibroblasts (CAFs) are abundant and heterogeneous in tumor microenvironment (TME). Cross-talk between cancer cells CAFs results progression. Here, we demonstrated that a distinct cancer-associated subset with podoplanin (PDPN) positive expression (PDPN + CAFs) was correlated poor survival oral squamous cell carcinoma (OSCC). PDPN promoted the progression of OSCC by transferring exosomal lncRNA FTX to cells. Mechanically, bound flap endonuclease-1 (FEN1), forming an...
The transcriptional cofactor receptor-interacting protein 140 (RIP140) is known as a deleterious regulator of cardiac mitochondrial function and energy metabolic homeostasis. This study revealed that RIP140 repressed Sirtuin 3 (SIRT3), deacetylase plays an important role in regulating function.RIP140 was overexpressed by adenovirus infection or knocked down RNA interference neonatal rat cardiomyocytes.RIP140 overexpression repressed, while silencing elevated the expression activity SIRT3....
Long non-coding RNA BRAF-activated non-protein coding plays bidirectional roles in human cancers. However, function and molecular mechanism of oral squamous cell carcinoma still need to clarify further.Long microarray assay, situ hybridization staining, clinicopathological data analysis were performed investigate expression pattern tissue samples. Constructing ectopically expressed cells via plasmids or siRNAs, then changeable abilities proliferation motility these observed vitro vivo....
Pulpotomy is an effective treatment for retaining vital pulp after exposure caused by caries removal and/or trauma. The expression of alpha smooth muscle actin (α-SMA) increased during the wound-healing process, and α-SMA-positive fibroblasts accelerate tissue repair. However, it remains largely unknown whether influence pulpal In this study, we established experimental rat pulpotomy model found that α-SMA was in dental relative to normal pulp. vitro results showed induction odontogenic...
Background: Human podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays critical role in tumor development. Cancer-associated fibroblasts (CAFs) are abundant and heterogeneous microenvironment. Cross-talk between cancer cells CAFs results progression. This study aimed to clarify the of podoplanin-positive (PDPN+ CAFs) oral squamous cell carcinoma (OSCC) progression.Methods: We used qRT-PCR immunohistochemistry detected expression PDPN stroma OSCC patients. performed lncRNA...
Abstract Cancer-associated fibroblasts (CAFs) are abundant and heterogeneous in tumor microenvironment. Cross-talk between cancer cells CAFs results progression. Here, we demonstrated that a distinct cancer-associated with podoplanin (PDPN) positive expression (PDPN + CAFs) was correlated poor survival oral squamous cell carcinoma (OSCC). PDPN promoted the progression of OSCC by transferring exosomal lncRNA FTX to cells. Mechanistically, bound flap endonuclease-1 (FEN1), forming an...