A5100323703- Rheumatoid Arthritis Research and Therapies
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Receptor Mechanisms and Signaling
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Circular RNAs in diseases
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Inflammatory mediators and NSAID effects
- Ginseng Biological Effects and Applications
- interferon and immune responses
- Natural product bioactivities and synthesis
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Liver physiology and pathology
- Medicinal Plant Pharmacodynamics Research
- Pharmacological Effects of Natural Compounds
Anhui Medical University
2016-2025
XinHua Hospital
2025
Sun Yat-sen University
2020-2025
Sun Yat-sen University Cancer Center
2022-2025
China Pharmaceutical University
2018-2025
Chinese PLA General Hospital
2024-2025
State Key Laboratory of Oncology in South China
2025
Yangzhou University
2017-2025
Capital Medical University
2025
Shanghai Jiao Tong University
2025
The absence of tumor necrosis factor (TNF) causes lethal infection by Leishmania major (L. major) in normally resistant C57BL/6J (B6.WT) mice. underlying pathogenic mechanism this fatal disease has so far remained elusive. We found that B6.WT mice deficient for the tnf gene (B6.TNF-/-) displayed not only a non-healing cutaneous lesion but also serious liver upon L. inoculation. Infected B6.TNF-/- developed an enlarged showed increased inflammation. Furthermore, we detected accumulating...
Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of adaptive starvation response. Among its effects, FGF21 induces hepatic fatty acid oxidation and ketogenesis, increases insulin sensitivity, blocks somatic causes bone loss. Here we show transgenic overexpression markedly extends lifespan in mice without reducing food intake or affecting markers NAD+ metabolism AMP kinase mTOR signaling. Transcriptomic analysis suggests acts...
Endoplasmic reticulum (ER) stress promotes tumor cell escape from immunosurveillance. However, the underlying mechanisms remain unknown. We hypothesized that ER induces hepatocellular carcinoma (HCC) cells to release exosomes, which attenuate antitumor immunity by modulating expression of programmed death ligand 1 (PD-L1) in macrophages. In this study, we demonstrated several markers (glucose-regulated protein 78, activating transcription factor 6, kinase R-like kinase, and...
Hepatitis C virus (HCV) infection usually induces chronic hepatic inflammation, which favors the initiation and progression of hepatocellular carcinoma (HCC). Moreover, microRNA-155 (miR-155) plays an important role in regulating both inflammation tumorigenesis. However, little is known about whether how miR-155 provides link between cancer. In this study we found that levels were markedly increased patients infected with HCV. MiR-155 transcription was regulated by nuclear factor kappa B...
Background: Chronic lesion activity driven by smoldering inflammation is a pathological hallmark of progressive forms multiple sclerosis (MS). Objective: To develop method for automatic detection slowly expanding/evolving lesions (SELs) on conventional brain magnetic resonance imaging (MRI) and characterize such SELs in primary MS (PPMS) relapsing (RMS) populations. Methods: We defined as contiguous regions existing T2 showing local expansion assessed the Jacobian determinant deformation...
Inflammatory diseases impair the reparative properties of endothelial progenitor cells (EPC); however, involvement diabetes in EPC dysfunction associated with myocardial infarction (MI) remains unknown. A model was established combining high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic mice infarction. The therapeutic effects transplanted wild-type EPC, Nlrp3 knockout and overexpression were evaluated. Chip Luciferase assay revealed CEBPB regulated transcriptional expression as a...
Wnt/β-catenin signaling is a critical regulator of skeletal physiology. However, previous studies have mainly focused on its roles in osteoblasts, while specific function osteoclasts unknown. This clinically important question because neutralizing antibodies against Wnt antagonists are promising new drugs for bone diseases. Here, we show that osteoclastogenesis, β-catenin induced during the macrophage colony-stimulating factor (M-CSF)-mediated quiescence-to-proliferation switch but...
MiR-133 was found to be specifically expressed in cardiac and skeletal muscle previous studies. There are two members the miR-133 family: miR-133a miR-133b. Although studies indicated that related myogenesis, signaling pathways regulated by were still not very clear. In this study, we showed both miR-133b upregulated during myogenesis through Solexa sequencing. We confirmed could promote myoblast differentiation inhibit cell proliferation regulation of extracellular signal-regulated kinase...
Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN). Alprostadil (Prostaglandin E1, PGE1) had protective effects on renal function. However, it unknown whether PGE1 inhibited insulin tubule epithelial cells via autophagy, which plays role DN against resistance. was induced by palmitic acid (PA) human HK-2 cells, shown as decrease insulin-stimulated AKT phosphorylation, glucose transporter-4 (GLUT4), uptake enhanced phosphorylation receptor...
Type 2 diabetes mellitus (DM) and obesity independently increase the risk of heart failure by incompletely understood mechanisms. We propose that hyperinsulinemia might promote adverse consequences in hearts subjects with type-2 DM obesity.High-fat diet feeding was used to induce wild-type mice or lacking β2-adrenergic receptor (β2AR) β-arrestin2. Wild-type fed high-fat were treated a β-blocker carvedilol GRK2 (G-protein-coupled kinase 2) inhibitor. examined signaling cardiac contractile...
Activation of cannabinoid receptor 2 (CB2R) ameliorates inflammation, but the underlying mechanism remains unclear. In present study, we examined whether activation CB2R could suppress nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome. peritoneal macrophages isolated from C57BL/6 mice, LPS/DSS challenge for 24 h increased expression components NLRP3 inflammasome NLRP3, Casp-1 p20/Casp-1 p45 ratio, proIL-1β IL-1β also enhanced autophagy (LC3-II/LC3-I Beclin-1...