A5101396783- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Antibiotic Resistance in Bacteria
- Circular RNAs in diseases
- Ion Channels and Receptors
- RNA modifications and cancer
- Signaling Pathways in Disease
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Pluripotent Stem Cells Research
- Helminth infection and control
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Biosensors and Analytical Detection
- Liver Disease and Transplantation
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Bacterial biofilms and quorum sensing
- Ubiquitin and proteasome pathways
- Parasites and Host Interactions
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
First Affiliated Hospital of Jiangxi Medical College
2025
Nanchang University
2007-2025
First Affiliated Hospital of Nanchang University
2007-2024
Beijing Normal University
2020-2024
People's Hospital of Xinjiang Uygur Autonomous Region
2017-2024
Central South University
2018-2023
Guiyang Medical University
2023
Affiliated Hospital of Guizhou Medical University
2023
Guangzhou Institutes of Biomedicine and Health
2017-2022
Chinese Academy of Sciences
2017-2022
Hepatitis C virus (HCV) infection usually induces chronic hepatic inflammation, which favors the initiation and progression of hepatocellular carcinoma (HCC). Moreover, microRNA-155 (miR-155) plays an important role in regulating both inflammation tumorigenesis. However, little is known about whether how miR-155 provides link between cancer. In this study we found that levels were markedly increased patients infected with HCV. MiR-155 transcription was regulated by nuclear factor kappa B...
Fibroblast growth factor (FGF) signaling plays critical roles in key biological processes ranging from embryogenesis to wound healing and has strong links several hallmarks of cancer. Genetic alterations FGF receptor (FGFR) family members are associated with increased tumor growth, metastasis, angiogenesis, decreased survival. JNJ-42756493, erdafitinib, is an orally active small molecule potent tyrosine kinase inhibitory activity against all four FGFR selectivity versus other highly related...
Hepatocellular carcinoma (HCC) is one of the most common cancers and shows a propensity to metastasize infiltrate adjacent more distant tissues. However, mechanisms that contribute tumor metastasis remain unclear. Here we evaluate effect Argonaute2 (Ago2), member Ago gene family plays role in short interfering RNA-mediated silencing, on HCC tumorigenesis, metastasis. We found Ago2 was frequently up-regulated specimens compared corresponding nontumor liver. Interestingly, overexpression can...
Objective: Colorectal cancer (CRC) is a fatal disease, and tumor development complex cellular event involving multistep cascade process proliferation, invasion, migration. In recent years, it has been shown that microRNA-126 (miR-126) plays key role in the tumorigenesis of CRC, but further studies are required to investigate regulatory mechanisms through which this miRNA affects cell viability, autophagy, apoptosis CRC. We aimed study effect miR-126 gene regulation CRC HCT116 cells. Methods:...
Abstract Objective This study was designed to analyze the structural characteristics of intestinal flora elderly Uygur patients with sarcopenia, thereby providing new ideas for clinical treatment. Methods Firstly, fecal samples were collected from 40 sarcopenia (Sarcopenia group) and healthy people (Control group). Next, significant differences in between two groups analyzed based on 16S rDNA high‐throughput sequencing. The linear discriminant analysis effect size (LEfSe) used estimate...
Some members of the transient receptor potential vanilloid (TRPV) subfamily cation channels are thermosensitive. Earlier studies have revealed distribution and functions these thermo-TRPVs (TRPV1-4) in various organs, but their expression function human esophagus not fully understood. Here, we probed for one nontumor esophageal squamous cell line two carcinoma (ESCC) lines. TRPV1, TRPV2, TRPV4 proteins were found to be upregulated ESCC cells, while TRPV3 was detectable any Subsequently,...
Objective Regional dissemination is the major cause of widespread prevalence a plasmid-encoding NDM-1 enzyme. We here investigated drug resistance, joint efficiency, and gene environment Klebsiella pneumoniae strain carrying blaNDM-1. Materials Methods Carbapenem-insensitive strains were analyzed using VITEK 2 Compact. Strains blaNDM-1 identified by polymerase chain reaction sequencing. Antimicrobial susceptibility testing plasmid conjugation experiment was then conducted. subjected to...
MyD88 gene mutation has been identified as one of the most prevalent driver mutations in activated B-cell-like diffuse large B-cell lymphoma (ABC DLBCL). The published literature suggests that interleukin-1 receptor-associated kinase 1 (IRAK1) is an essential for ABC DLBCL harboring mutation. Importantly, scaffolding function IRAK1, rather than its activity, required tumor cell survival. Herein, we present our design, synthesis, and biological evaluation a novel series potent selective IRAK1...
The CRISPR/Cas systems offer a programmable platform for nucleic acid detection, and CRISPR/Cas-based diagnostics (CRISPR-Dx) have demonstrated the ability to target acids with greater accuracy flexibility. However, due configuration of reporter underlying labeling mechanism, almost all reported CRISPR-Dx rely on single-option readout, resulting in limitations end-point result readouts. This is also associated high reagent consumption delays diagnostic reports protocol differences. Herein,...
The present study investigated whether microRNA (miR)‑132‑3p targeted transcription factor SOX‑4 (Sox4) for the inhibition of proliferation, migration, invasion and promotion apoptosis in liver cancer (LC) cells. expression miR132‑3p Sox4 mRNA was evaluated by quantitative PCR protein determined western blot analysis. Cell apoptosis, were assessed at different time points MTT assay, flow cytometry analysis, wound healing assay Transwell migration respectively. Bioinformatics prediction...
Progression of liver failure to coma is a dynamic process. Its prognosis depends primarily on early diagnosis, real-time monitoring the disease, and appropriate therapy. Current detection methods repeated blood sampling do not effortlessly meet clinical requirements. This pilot study aimed assess potential exhaled breath analysis by extractive electrospray ionization mass spectrometry (EESI-MS) as noninvasive tool diagnose provide failure. A total 24 healthy controls, 20 chronic hepatitis B...
Aim: The association between transforming growth factor‐β1 ( TGF‐β1 ) gene polymorphisms and hepatocellular cancer (HCC) risk has been widely reported, but results were somewhat controversial. To derive a more precise estimation of the relationship HCC risk, we conducted meta‐analysis all available studies relating C‐509T and/or T869C to developing HCC. Methods: Two investigators independently searched MEDLINE, PubMed, Web Science, Embase, CNKI (China National Knowledge Infrastructure) CBM...
Platelet-derived growth factor BB (PDGF-BB) is a potential biomarker of tumor angiogenesis. For the first time, we developed highly sensitive aptasensor for PDGF-BB with an enhanced test line signal by using two different gold nanoparticles (AuNPs). Herein, describe biosensor detection that combines biotinylated aptamer on sample pad and poly thymine-Cy3-AuNP-monoclonal antibody complexes against immobilized conjugate A. Streptavidin (SA) rabbit anti-mouse polyclonal were also in...
Puerarin, an isoflavone-C-glucoside extracted from the root of Pueraria Labata (Willd.) Ohwi, is one most important crude herbs used in Chinese medicine for various medicinal purposes. Accumulating evidence has indicated that puerarin suppresses bone resorption and promotes formation. However, molecular mechanism involved puerarin-associated formation unclear. The present study aimed to investigate puerarin-induced osteoblast proliferation differentiation. showed treatment differentially...
The calcineurin/nuclear factor of activated T cell (CN/NFAT) signaling pathway plays a critical role in the immune response. Therefore, inhibition CN/NFAT is an important target for inflammatory disease. conserved PXIXIT and LXVP motifs CN substrates targeting proteins have been recognized. Based on affinity ability inhibitory effect these docking sequences CN, we designed bioactive peptide (named pep3) against interaction, which has two binding sites derived from RCAN1-PXIXIT motif...
Abstract Introduction Decision making as a complex cognitive process involves assessing risk, reward, and costs. Typically, it has been studied in nonsocial contexts. We have developed novel laboratory model used with rodents to detect food‐foraging decision‐making strategies different social settings. However, the brain regions that mediate these behaviors are not well identified. Substantial evidence shows anterior cingulate cortex ( ACC ) participates evaluation of information decision...
The present study aimed to investigate the expression and function of aquaporin (AQP)9 in intestinal tract acute liver injury rat models. A total 20 Sprague Dawley rats were randomly divided into four groups: Normal control (NC) group groups (24, 48 72 h). Acute models established using D‑amino galactose, serum levels alanine aminotransferase (ALT), aspartate (AST), bilirubin (Tbil) albumin determined an automatic biochemical analyzer. Proteins myosin light chain kinase (MLCK) mucosa...
This study aimed to explore the epidemic, clinical characteristics, and molecular virulence attributes of Klebsiella pneumoniae serotype K54 (K54-Kp). A retrospective was conducted on 328 strains screened in a Chinese hospital from January 2016 December 2019. The genes antibiotic resistance (ARGs) were detected by PCR, drug sensitivity test adopted detect resistance. Multilocus sequence typing (MLST) PFGE performed determine clonal correlation between isolates. Biofilm formation assay, serum...
BACKGROUND This study was designed to detect and analyze miR-146b-mediated circular RNA (circRNA) expression in hepatic stellate cells. MATERIAL AND METHODS The experiment divided into a control group siRNA-miR-146b group. interference efficiency of confirmed by real-time quantitative reverse transcription PCR (qRT-PCR) the cells were collected, total collected for high flux sequencing. miRNA-targeted carcass predicted. Finally, 5 circRNAs verified qRT-PCR. RESULTS miR-146b significantly...
Calcineurin (CN) controls the immune response by regulating nuclear factor of activated T cells (NFAT). Inhibition CN function is an effective treatment for diseases. The PVIVIT peptide artificial based on NFAT-PxIxIT motif, which exhibits stronger binding to CN. A bioactive (named pep4) that inhibits CN/NFAT interaction was designed. Pep4 contains a segment A238L as linker and LxVP motif sites. has strong capacity activity competitively. 11-arginine-modified pep4 (11 R-pep4) translocation...