A5100424077- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- CRISPR and Genetic Engineering
- Synthesis and biological activity
- Sulfur-Based Synthesis Techniques
- Pluripotent Stem Cells Research
- Microbial Metabolic Engineering and Bioproduction
- Cyclopropane Reaction Mechanisms
- Synthesis and Biological Evaluation
- Radical Photochemical Reactions
- Viral Infectious Diseases and Gene Expression in Insects
- Biofuel production and bioconversion
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Ion Channels and Receptors
- Supramolecular Self-Assembly in Materials
- Synthesis and Characterization of Heterocyclic Compounds
- Asymmetric Synthesis and Catalysis
- Quinazolinone synthesis and applications
- Surfactants and Colloidal Systems
- Click Chemistry and Applications
- Enzyme Catalysis and Immobilization
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Reactions
- Advanced Polymer Synthesis and Characterization
Chengde Medical University
2022-2025
Ministry of Agriculture and Rural Affairs
2025
Shandong Academy of Agricultural Sciences
2025
Duke University
2020-2024
Xinjiang University
2024
Changzhou University
2022-2024
Qufu Normal University
2018-2023
Guangxi University
2023
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2023
Guangdong Academy of Agricultural Sciences
2023
Copper-catalysed remote C−H bond sulfonylation of aminoquinolines using commercially available and inexpensive arylsulfonyl chlorides as the reagents is described.
Chiral self-assemblies constantly attract great interest because of their potential to provide insight into biological systems and materials science. Herein we report on the efficient preparation alanine-based chiral metallacycles, rhomboids 1D 1L hexagons 2D 2L using a Pt(II) ← pyridyl directional bonding approach. The metallacycles are subsequently assembled nanospheres at low concentration, that generate metallogels high concentration driven by hydrogen bonding, hydrophobic π–π...
CREB-target gene transcription during neuronal excitation is important for many aspects of development and function, including dendrite morphogenesis. However, the signaling events that regulate cAMP response element-binding protein (CREB)-mediated dendritic are not well understood. Herein we report CREB coactivator TORC1 (transducer regulated 1) required activity-dependent expression growth in developing cortical neurons. Ca(2+) influx via voltage-gated calcium channels induced...
Late-phase long-term potentiation (L-LTP) and memory depend on the transcription of mRNA CRE-driven genes synthesis proteins. However, how synaptic signals propagate to nucleus is unclear. Here we report that CREB coactivator TORC1 (transducer regulated activity 1) undergoes neuronal activity-induced translocation from cytoplasm nucleus, a process required for CRE-dependent gene expression L-LTP. Overexpressing dominant-negative form or down-regulating prevented activity-dependent target in...
Ammonium ylides have a long history in organic synthesis, but their application asymmetric catalysis is still underdeveloped regard to both substrate scope and reaction pathways compared with phosphorus sulfur ylides. Here previously unreported [4 + 1] annulation of 3-bromooxindoles electron-deficient 1-azadienes has been developed through ammonium ylide newly designed 2'-methyl α-isocupreine (α-MeIC), efficiently delivering spirocyclic oxindole compounds incorporating dihydropyrrole motif...
An l-glutamic acid terminated amphiphilic diacetylene was designed and found to self-assemble into vesicles in water supramolecular gel with helical structures mixed methanol/water solvent. Both the helices underwent topochemical photopolymerization under UV irradiation changed a blue color. During self-assembly photopolymerization, chirality of localized successfully transferred polydiacetylene (PDA), which resulted obvious CD signals PDA phase. Interestingly, for were opposite due...
A useful approach is developed for the synthesis of various structurally interesting spirocyclic sultams and heterobiaryls using a cross-dehydrogenative coupling strategy that features high atom step economy. This method employs [Cp*RhCl2]2 as catalyst N-sulfonylimine, weak coordinating group, an efficient directing group to assist C-H activation. number coupled products were converted into molecules through further synthetic transformations.
An operationally simple, Pd-catalyzed C–H functionalization is described for the synthesis of important and useful isoindolinones from readily available carboxamides carboxylic acids or anhydrides. The reactions proceed efficiently with a broad range substrates under redox-neutral reaction conditions tolerate diversity functional groups. mechanistic investigation suggests that involve activation, nucleophilic addition, β-O elimination, dehydration steps.
By integration of iminyl radical-triggered 1,5-hydrogen atom transfer and (5+2) or (5+1) annulation processes, a series structurally novel interesting azepine spiro-tetrahydropyridine derivatives have been successfully prepared in moderate to good yields. This method utilizes FeCl2 as the catalyst readily available oximes five-atom units, while showcasing broad substrate scope functional group compatibility. The products can be easily converted into many valuable compounds. Moreover, DFT...
Cyclin-Dependent Kinase (CDK) 12 is a member of the 20-membered CDK family (CDK1-20) and plays vital role in regulating gene transcription, mRNA splicing, translation, cell cycle, repair DNA damage. CDK12 an emerging therapeutic target due to its transcription Damage Response (DDR) genes (CDK). However, development selective small molecules targeting has been challenging high degree homology between kinase domains other transcriptional CDKs, most notably CDK13. So far, no inhibitors approved...
Salt stress, as a significant adverse consequence of global climate change, severely restricts the yield and quality watermelon. In this study, salt-tolerant cultivar T23 salt-sensitive B2 were subjected to 200 mM NaCl treatment (0 h, 6 24 48 168 h) at three-leaf stage, adaptation mechanisms watermelon roots salt stress systematically investigated phenotypic, physiological, gene transcription levels. Phenotypic observations revealed that inhibited seedling growth, caused leaf curling,...
A useful method for the synthesis of ortho-olefinated ketimines from readily accessible cyclic N-sulfonyl and various olefins has been achieved. The reactions proceeded by Rh(III)-catalyzed, ketimine-directed C–H cleavage under aerobic conditions. Further synthetic transformations olefinic products led to interesting heterocyclic molecules.
Abstract Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a progressive autosomal dominant neurodegenerative caused by abnormal CAG repeats in the exon 10 of ATXN3 . The accumulation mutant ataxin-3 proteins carrying expanded polyglutamine (polyQ) leads to selective degeneration neurons. Since pathogenesis SCA3 has not been fully elucidated, and no effective therapies have identified, it crucial investigate seek new therapeutic strategies SCA3. Induced pluripotent stem...
Bimetallic Schiff-base complexes with different bridging parts and silyl-substituents were applied for stereoselective ROP of<italic>rac</italic>-LA, copolymerisation of<italic>rac</italic>-LA/ε-CL.
Indirubin, a traditional Chinese medicine formulation from the Muricidae family, has been reported to exhibit abroad anti-cancer and anti-inflammation activities mediate nuclear factor-κB (NF-κB) signal. Thus, this study aimed investigate protective effects of indirubin on LPS-induced acute lung injury potential mechanism in mice. The results showed that LPS treatment caused oxidative stress inflammation Indirubin alleviated LPS-caused via reducing MDA abundance IL-1β TNF-α expressions...