Dienamines formed in situ from a chiral secondary amine and an α,β-unsaturated aldehyde undergo the highly α-regioselective title reaction to give densely functionalized piperidine derivatives with excellent enantioselectivity (see scheme). The products were converted into variety of versatile cyclic frameworks. Ts=4-toluenesulfonyl. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...

A new formal [3 + 1]-cycloaddition reaction of azaoxyallyl cation intermediates, generated in situ from α-halo hydroxamates bearing α-alkyl groups, and sulfur ylides is reported, furnishing useful β-lactams (dr >19:1) fair to modest yields. In contrast, an unexpected 2]-cycloaddition occurs give γ-lactam derivatives for with α-aryl groups the presence bases.

A tri-ing reaction: An asymmetric Diels–Alder cycloaddition of δ,δ-disubstituted 2,4-dienones is possible through the trienamine catalysis cinchona-based primary amines (see scheme). array electron-deficient dienophiles, such as N-substituted maleimides and 3-alkenyl oxindoles, were tolerated, multifunctional cyclohexene derivatives obtained in excellent stereoselectivity with high diastereomer ratios. Detailed facts importance to specialist readers are published "Supporting Information"....

Ammonium ylides have a long history in organic synthesis, but their application asymmetric catalysis is still underdeveloped regard to both substrate scope and reaction pathways compared with phosphorus sulfur ylides. Here previously unreported [4 + 1] annulation of 3-bromooxindoles electron-deficient 1-azadienes has been developed through ammonium ylide newly designed 2'-methyl α-isocupreine (α-MeIC), efficiently delivering spirocyclic oxindole compounds incorporating dihydropyrrole motif...

A highly enantioselective Michael addition of alpha-substituted cyanoacetates to vinyl ketones was accomplished in the presence simple bifunctional thiourea/tertiary amine organocatalysts. number alpha-aryl or alkyl have been successfully applied give multifunctional compounds with an all-carbon-substituted quaternary stereocenter excellent enantioselectivities (82-97 % ee) and yields (61-99 %). The optical pure adducts could be smoothly converted variously structured beta(2,2)-amino acid...

Abstract The analysis of driving forces and spatiotemporal characteristics flash flood disasters is the foundation for regional disaster early warning prevention planning. Due to its unique geographical climatic conditions, Fujian Province experiences frequent disasters. In‐depth research on distribution in great significance establishing a system mitigating province. A geographic database risk was constructed based big data deeply explore factors spatio‐temporal floods. By sorting analyzing...

Multifunktionelle Cyclohexenderivate entstehen bei einer asymmetrischen Diels-Alder-Cycloaddition von δ,δ-disubstituierten 2,4-Dienonen, die über Trienaminkatalyse unter Verwendung primärer Cinchona-Amine abläuft (siehe Schema). Elektronenarme Dienophile wie N-substituierte Maleimide und 3-Alkenyloxindole wurde umgesetzt, Cyclohexene wurden mit ausgezeichneter Stereoselektivität hohem Diastereomerenverhältnis erhalten. Detailed facts of importance to specialist readers are published as...

Abstract Three 1H‐benzimidazole‐5‐carboxylate (Hbic – )‐based coordination polymers, {[Ni(H 2 O)(Hbic) ] · 2H O} n ( 1 ), O) (Hbic) 3H and {[Co (H 4 4DMF 3 ) were obtained by reactions of the ligand H bic Ni II or Co salts in presence different structure directing molecules. They structurally characterized single‐crystal X‐ray diffraction, IR spectra, elemental analysis, thermal stability, luminescent, magnetic measurements. Structural analysis suggests that three polymers exhibit a 2D (4,...

Equity in the distribution of medical facilities is critical to effectiveness healthcare investments and equality residents' right health. In recent years, Chinese Government has been working establish a well-organized hierarchical system facilities. However, few studies have focused on evaluation multilevel facility accessibility equity, they are usually based single urban road network without considering distinction between walkways carriageways. To address these issues, this study...

중국의 '쌍감(双减)' 정책의 교육 배경 하에서, 어린이의 다원적 발전에 유리한 어린이 도서관을 논의하는 것은 중요한 의미를 지닌다. 본문에서는 선행 연구를 분석하고 이론 연구 방법을 통해 도서관 공간 환경 설계에서 주목해야 할 평가 요소를 요약하고, 각 요소에 따른 내용을 도출하였다. 이후 사례 사용하여 조사 사례를 평가하였다. 사례에서 얻은 결과는 대부분의 도서관이 현재 사용자의 기본 요구를 중점적으로 다루고 있으며, 발전 관점에서 설계하지 못하고 있다는 것을 보여준다. 또한, 심미성의 결여는 조명 기구, 보조 광원 설계, 벽면 형상 등에서 집중적으로 나타나며, 다양성의 형식의 단일성, 가구 선택 및 배치 단일성 주로 나타난다.

A diverse array of fused [6-6-5] tricyclic heterocycles has been synthesized

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”

Abstract Methyl α‐isocupreine catalyst is successfully applied in the asymmetric [4 + 1] annulation of 3‐bromooxindoles (I) with 1‐azadienes (II) leading to spirocyclic dihydropyrrole‐oxindoles (III) excellent enantioselectivities.

Abstract The present new title reaction catalyzed by a secondary chiral amine is applicable to wide range of aryl‐substituted indole derivatives (I) and α,β‐unsaturated aldehydes.

Eine asymmetrische Diels-Alder-Cycloaddition von δ,δ-disubstituierten 2,4-Dienonen unter Trienaminkatalyse an primäre Amine auf Cinchona-Basis wurde entwickelt. In der Zuschrift S. 4477 ff. zeigen Y.-C. Chen et al., dass zahlreiche elektronenarme Dienophile dieser Reaktion teilnehmen und mit ausgezeichneter Stereoselektivität hoch funktionalisierte Cyclohexene liefern. Enzymmodelle Die Einführung Aminosäure imiTyr, die eine Tyr-His-Verknüpfung imitiert, in ein Myoglobin-Modell...

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”

Abstract The δ,δ‐substitution pattern of the 2,4‐dienones is necessary for reaction.

Abstract Review: 63 refs.