A5029161106- Inflammasome and immune disorders
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Cell death mechanisms and regulation
- Genomics and Phylogenetic Studies
- Plant Pathogenic Bacteria Studies
- Pancreatic function and diabetes
- Research in Cotton Cultivation
- Plant-Microbe Interactions and Immunity
- interferon and immune responses
- Mesenchymal stem cell research
- Retinal Development and Disorders
- Bacteriophages and microbial interactions
- Microbial Metabolic Engineering and Bioproduction
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Lipid metabolism and biosynthesis
- Cancer-related molecular mechanisms research
- Anatomy and Medical Technology
- Ubiquitin and proteasome pathways
Central South University
2015-2025
Kunming University of Science and Technology
2014-2025
Stanford University
2024-2025
Henan University
2024-2025
Sun Yat-sen University
2014-2025
Nanjing Medical University
2022-2025
Jiangsu Province Hospital
2025
Shanghai Jiao Tong University
2022-2025
Third Affiliated Hospital of Sun Yat-sen University
2019-2025
Hainan Medical University
2022-2025
Phytosterols are important micronutrients in human diets. Evidence has shown that phytosterols play an essential role the reduction of cholesterol blood and therefore decrease cardiovascular morbidity. In this study, content composition different kinds vegetable oils were analyzed, total phytosterol intake contribution foods to estimated based on consumption data. The results showed contents rice bran oil, corn rapeseed oil higher than those other Chinese diet was about 392.3 mg/day. main...
Mesenchymal stem cells (MSCs) have been reported to exert therapeutic effects on immunoregulation, tissue repair, and regeneration from the bench bedside. Increasing evidence demonstrates that extracellular vesicles (EVs) derived MSCs could contribute these are considered as a potential replacement for cell-based therapies. However, efficacy underlying mechanisms of EV-based treatment in hepatic ischemia-reperfusion injury (IRI) remain unclear. Here, we demonstrated human umbilical cord...
PANoptosis is a newly identified type of regulated cell death that consists pyroptosis, apoptosis, and necroptosis, which simultaneously occur during the pathophysiological process infectious inflammatory diseases. Although our previous literature mining study suggested might in neuronal ischemia/reperfusion injury, little experimental research has been reported on existence PANoptosis. In this study, we used vivo vitro retinal models injury to investigate whether PANoptosis-like...
Abstract Progressive retinal ganglion cells (RGCs) death that triggered by ischemia reperfusion (IR), leads to irreversible visual impairment and blindness, but our knowledge of post-IR neuronal related mechanisms is limited. In this study, we first demonstrated apart from necroptosis, which occurs before apoptosis, ferroptosis, characterized iron deposition lipid peroxidation, involved in the whole course IR mice. Correspondingly, all three types RGCs were found retina samples human...
Abstract Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, body maintains copper homeostasis. deficiency or excess can adversely affect cellular function. Therefore, homeostasis stringently regulated. Recent studies suggest that trigger specific form of cell death, namely, cuproptosis, which triggered by excessive levels intracellular copper. Cuproptosis induces aggregation mitochondrial...
Rationale: Endothelial dysfunction results in sustained and chronic vascular inflammation, which is central to atherosclerotic diseases. However, transcriptional regulation of endothelial inflammation has not been well clarified. Objective: This study aims explore Foxp (forkhead box P) transcription factor 1 homeostasis, atherogenesis, its mechanisms. Methods Results: To assess the importance Foxp1 atherosclerosis, expression was analyzed human coronary artery mouse artery, we observed...
Microglia are innate immune cells in the central nervous system (CNS), that supplies neurons with key factors for executing autophagosomal/lysosomal functions. Macroautophagy/autophagy is a cellular catabolic process maintains cell balance response to stress-related stimulation. Abnormal autophagy occurs many pathologies, such as cancer, and autoimmune neurodegenerative diseases. Hence, clarification of mechanisms regulation utmost importance. Recently, researchers presented microRNAs...
Abstract miR-21 is aberrantly expressed, and plays a role in various types of tumors many other diseases. However, the mechanism LPS-induced septic shock still unclear. In this study, we investigated pyroptosis shock. Here, show that deficiency inhibited NLRP3, ASC, caspase-1 expression, as well inflammasome activation myeloid cells from both mice humans. We found NF-κB pathway was regulated by miR-21, A20 direct target miR-21. Furthermore, ASC pyroptosome, which restrained GSDMD cleavage,...
Some scholars have recently developed the concept of PANoptosis in study infectious diseases where pyroptosis, apoptosis and necroptosis act consort a multimeric protein complex, PANoptosome. This allows all components to be regulated simultaneously. provides new way regulation cell death, that different types death may at same time. To test whether exists other than diseases, we chose cerebral ischemia/reperfusion injury as research model, collected articles researching from three major...
There are two types of cell death-apoptosis and necrosis. Apoptosis is death regulated by signaling pathways, while necrosis has until recently been considered a passive mechanism caused environmental pressures. However, recent studies show that can also be specific pathways. This mode death, termed necroptosis, found to related the occurrence development many diseases. We used bibliometrics analyze global output literature on necroptosis in field neuroscience published period 2007–2019...
Abstract Progressive pancreatic β-cell dysfunction is recognized as a fundamental pathology of type 2 diabetes (T2D). Recently, mesenchymal stem cells (MSCs) have been identified in protection islets function T2D individuals. However, the underlying mechanisms remain elusive. It widely accepted that closely related to improper accumulation macrophages islets, and series reports suggest MSCs possess great immunomodulatory properties by which they could elicit into an anti-inflammatory M2...
Schematic of the synthetic route for fluorescent CDs-BC and their applications in detection of<italic>p</italic>-NP bioimaging.
Common bean (Phaseolus vulgaris) is an essential crop with high economic value. The growth of this plant sensitive to environmental stress. Heat shock factor (Hsf) a family antiretroviral transcription factors that regulate defense system against biotic and abiotic To date, few studies have identified bio-analyzed Hsfs in common bean.In study, 30 Hsf (PvHsf1-30) were from the PFAM database. PvHsf1-30 belonged 14 subfamilies similar motifs, gene structure cis-acting elements. members...
Abstract Mitochondria generate ATP and play regulatory roles in various cellular activities. Cancer cells often exhibit fragmented mitochondria. However, the underlying mechanism remains elusive. Here we report that a mitochondrial protein FUN14 domain containing 2 ( FUNDC2 ) is transcriptionally upregulated primary mouse liver tumors, approximately 40% of human hepatocellular carcinoma (HCC). Importantly, elevated expression inversely correlates with patient survival, its knockdown inhibits...