A5050160272- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- ATP Synthase and ATPases Research
- Photosynthetic Processes and Mechanisms
- Metabolism and Genetic Disorders
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- Dietary Effects on Health
- Phytochemical and Pharmacological Studies
- Folate and B Vitamins Research
- Gut microbiota and health
- Amino Acid Enzymes and Metabolism
- Reproductive System and Pregnancy
- Cellular transport and secretion
- Fungal and yeast genetics research
- Adenosine and Purinergic Signaling
- Genetics and Neurodevelopmental Disorders
- Autophagy in Disease and Therapy
- Retinal Imaging and Analysis
- Metabolism, Diabetes, and Cancer
- Retinal Diseases and Treatments
- Genetic Neurodegenerative Diseases
Zhejiang University
2021-2025
Women's Hospital, School of Medicine, Zhejiang University
2024-2025
Sanya University
2024-2025
Jiangxi Normal University
2024
First Affiliated Hospital Zhejiang University
2022-2024
Hangzhou Center for Disease Control and Prevention
2022
Shanghai Clinical Research Center
2022
The University of Texas Southwestern Medical Center
2015-2020
Wayne State University
2013-2020
The University of Texas at Dallas
2018
Circadian rhythmicity is a defining feature of mammalian metabolism that synchronizes metabolic processes to day-night light cycles. Here, we show the intestinal microbiota programs diurnal rhythms in mouse small intestine through histone deacetylase 3 (HDAC3). The induced expression epithelial HDAC3, which was recruited rhythmically chromatin, and produced synchronized oscillations acetylation, gene expression, nutrient uptake. HDAC3 also functioned noncanonically coactivate...
Abstract Mitochondria generate ATP and play regulatory roles in various cellular activities. Cancer cells often exhibit fragmented mitochondria. However, the underlying mechanism remains elusive. Here we report that a mitochondrial protein FUN14 domain containing 2 ( FUNDC2 ) is transcriptionally upregulated primary mouse liver tumors, approximately 40% of human hepatocellular carcinoma (HCC). Importantly, elevated expression inversely correlates with patient survival, its knockdown inhibits...
Abstract Methionine restriction (MR) provides metabolic benefits in many organisms. However, mechanisms underlying the MR-induced effect remain incompletely understood. Here, we show budding yeast S. cerevisiae that MR relays a signal of S-adenosylmethionine (SAM) deprivation to adapt bioenergetic mitochondria nitrogenic anabolism. In particular, decreases cellular SAM constrain lipoate metabolism and protein lipoylation required for operation tricarboxylic acid (TCA) cycle mitochondria,...
Diabetic retinopathy (DR) is the leading cause of blindness among working-age population. Although controlling blood glucose levels effectively reduces incidence and development DR to less than 50%, there are currently no diagnostic biomarkers or effective treatments for in glucose-well-controlled diabetic patients (GW-DR). In this study, we established a prospective GW-DR cohort by strictly adhering glycemic control guidelines maintaining regular retinal examinations over median 2-year...
Diabetic kidney disease (DKD) is a leading cause of end-stage renal (ESRD).Mitochondrial dysfunction in tubules, occurring early the disease, linked to development DKD, although underlying pathways remain unclear.Here, we examine diabetic human and mouse kidneys, HK-2 cells exposed high glucose, show that glucose disrupts mitochondria-associated endoplasmic reticulum membrane (MAM) causes mitochondrial fragmentation.We find conditions increase mitogen-activated protein kinase 1(MAPK1),...
Although inositol pyrophosphates have diverse roles in phosphate signaling and other important cellular processes, little is known about their functions the biosynthesis of phospholipids. Here, we show that KCS1, which encodes an pyrophosphate kinase, a regulator metabolism. Deletion blocks synthesis on 5-hydroxyl ring, causes auxotrophy decreased intracellular phosphatidylinositol. These defects are caused by profound decrease transcription INO1, myo-inositol-3-phosphate synthase....
Abstract Regulating cardiolipin to maintain mitochondrial homeostasis is a promising strategy for addressing Parkinson's disease (PD). Through comprehensive screening and validation process involving multiple models, ginsenoside Rg3 (Rg3) as compound capable of enhancing levels identified. This augmentation in fosters by bolstering unfolded protein response, promoting mitophagy, oxidative phosphorylation. Consequently, this cascade enhances the survival tyrosine hydroxylase positive (TH + )...