A5100679744- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Diabetes Management and Research
- Pregnancy and preeclampsia studies
- Cardiovascular Function and Risk Factors
- Oral and Maxillofacial Pathology
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Thyroid Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- Cardiovascular Health and Disease Prevention
- Bariatric Surgery and Outcomes
- Bone health and osteoporosis research
- Retinal Imaging and Analysis
Shanghai Jiao Tong University
2016-2025
Nanchang University
2024-2025
Shanghai First People's Hospital
2016-2025
University of Chinese Academy of Sciences
2023-2025
Chinese Academy of Sciences
2023-2025
Anhui Medical University
2024-2025
First Affiliated Hospital of Anhui Medical University
2024-2025
Ministry of Agriculture and Rural Affairs
2025
Shanghai Ocean University
2025
Hainan Medical University
2024
Spexin mRNA and protein are widely expressed in rat tissues associate with weight loss rodents of diet-induced obesity. Its location endocrine epithelial cells has also been suggested. is a novel peptide that involves Therefore, we aimed to examine its expression human test whether spexin could have role glucose lipid metabolism type 2 diabetes mellitus (T2DM). The the gene immunoreactivity adrenal gland, skin, stomach, small intestine, liver, thyroid, pancreatic islets, visceral fat, lung,...
Triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) has been recommended as a surrogate marker for insulin resistance. In the present study, we aimed investigate relationship between TG/HDL-C and NAFLD in an apparently healthy population.A total of 18,061 subjects who participated health checkup program were included. was diagnosed by ultrasonography.The prevalence rate 24.8% whole population, progressively increased across quartiles (4.9, 14.1, 26.8 53.5%,...
Objective: Recent studies demonstrate circulating serum spexin levels are reduced in obesity or type 2 diabetes mellitus (T2DM) patients and may play a role glucose metabolism.The mechanism underlying is not known.In this study, we explore whether has insulin resistance hepatic metabolism.Methods: The correlation between the homeostasis model assessment of (HOMA-IR) was studied newly diagnosed T2DM patients.After intraperitoneal injection exogenous for 8 weeks, effect on infusion rates...
Diabetic retinopathy (DR) is the leading cause of blindness among working-age population. Although controlling blood glucose levels effectively reduces incidence and development DR to less than 50%, there are currently no diagnostic biomarkers or effective treatments for in glucose-well-controlled diabetic patients (GW-DR). In this study, we established a prospective GW-DR cohort by strictly adhering glycemic control guidelines maintaining regular retinal examinations over median 2-year...
Genetic information is involved in the gradual emergence of cortical areas since neural tube begins to form, shaping heterogeneous functions circuits human brain. Informed by invasive tract-tracing measurements, cortex exhibits marked interareal variation connectivity profiles, revealing heterogeneity across areas. However, it remains unclear about organizing principles possibly shared genetics and wiring manifest spatial cortex. Instead considering a complex one-to-one mapping between...
Obesity is associated with a state of chronic low-grade inflammation, which contributes to insulin resistance and type 2 diabetes. However, the molecular mechanisms that link obesity inflammation are not fully understood. Follistatin-like 1 (FSTL1) novel proinflammatory cytokine expressed in adipose tissue secreted by preadipocytes/adipocytes. We aimed test whether FSTL1 could have role obesity-induced resistance. It was found expression markedly decreased during differentiation 3T3-L1...
Obesity‐induced endoplasmic reticulum (ER) stress and inflammation lead to adipocytes dysfunction. Autophagy helps adapt cellular involves in regulating innate inflammatory response. In present study, we examined the activity of rapamycin, a mTOR kinase inhibitor, against adipocytes. An vitro model was used which 3T3‐L1 were preloaded with palmitate (PA) generate artificial hypertrophy mature Elevated autophagy flux increased number autophagosomes observed response PA rapamycin treatment....
Background and Aim:Helicobacter pylori infection has been reported to promote the development of a variety extra-digestive manifestations, including type 2 diabetes, cardiovascular liver diseases. Recently, association between H. non-alcoholic fatty disease (NAFLD) was also proposed. However, evidence from different studies controversial. We therefore performed this study investigate relationship them in large population apparently healthy subjects China. Methods: A total 21,456 underwent...
Endoplasmic reticulum (ER) stress and inflammation induced by obesity lead to adipocyte dysfunction, with the impairment of insulin pathway. Recent studies have indicated that understanding physiological role autophagy is great significance. In present study, an in vitro model was used which 3T3-L1 adipocytes were pre-loaded palmitate (PA) generate artificially hypertrophied mature adipocytes. PA autophagic flux, determined increased microtubule-associated protein 1 light chain 3 (LC3)-II...
High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker. This study aimed to identify the correlation between hs-CRP levels and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).This cross-sectional observational included 927 T2DM. We collected data of based on their medical data, including sociodemographic characteristics, concomitant diseases, laboratory results, therapy. Multivariate logistic regression analysis was conducted assess relationship...
Abstract Exercise benefits M2 macrophage polarization, energy homeostasis and protects against obesity partially through exercise-induced circulating factors. Here, by unbiased quantitative proteomics on serum samples from sedentary exercised mice, we identify parvalbumin as a factor suppressed exercise. Parvalbumin functions non-competitive CSF1R antagonist to inhibit activation expenditure in adipose tissue. More importantly, concentrations of positively correlate with mouse human, while...
Objective This study evaluated the effect of continuous glucose monitoring (CGM) versus self-monitored blood (SMGB) in gestational diabetes mellitus (GDM) with hemoglobin A1c (HbA1c) <6%. Methods From January 2019 to February 2021, 154 GDM patients HbA1c<6% at 24–28 weeks were recruited and assigned randomly either SMBG only or CGM addition SMBG, 77 participants each group. was used combination fingertip every four until antepartum group, while applied. The metrics after 8...
Abstract Helicobacter pylori is a prevalent bacterial pathogen globally, implicated in various gastrointestinal disorders. Current recommended antibiotic therapies for H. infection have been proven to be therapeutically insufficient, with low eradication rates and high recurrence rates. Emerging evidence suggests that therapy can lead subsequent vaginal dysbiosis, posing challenges conventional approaches. Thus, this article proposes novel probiotic involving simultaneous oral intra-vaginal...
Objective Investigate the diversity of gut microbiota in children with peanut allergies and assess its association allergic reactions. Identify potential microbial biomarkers for diagnosis treatment allergies. Methods Twenty-nine allergy who visited hospital from December 2020 to 2022 were selected as test group (PA), twenty-seven healthy underwent physical examination during same period tested negative IgE control (Ctl). The differences between two groups compared. study enrolled 29 (PA...
To assess the association between serum uric acid (SUA) level and prevalence of diabetic retinopathy (DR) chronic kidney disease (CKD) in patients with long-term diabetes. A cross-sectional analysis was conducted involving from Shanghai General hospital during October 2018 2021. Participants underwent measurements SUA, renal function test DR assessments via fundus photography. Multivariable ordinal logistic regression models assessed odd ratios (ORs) 95% confidence intervals (95% CIs) for...
The study of cortical geometry and connectivity is prevalent in research on the human brain. However, these two aspects brain structure are usually examined separately, leaving essential connections between brain's folding patterns white matter unexplored. In this study, we aimed to elucidate fundamental links tract connectivity. We developed concept tract-geometry coupling (TGC) by optimizing alignment cortex multiscale geometry. Specifically, spectral analyses surface yielded a set...
Across-sectional study was performed in 541 type 2 diabetic patients to determine the relationship between serum uric acid (SUA) and NAFLD patients. Clinical parameters including SUA were determined diagnosed by ultrasonography. significantly higher subjects with than those without men, but not women. Furthermore, prevalence rate of increased progressively across sex-specific tertiles only men (37.9%, 58.6%, 72.6%, resp., <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Objective This study aimed to explore the relationship of thyroid function and glucose metabolism investigate changes in after National Metabolic Management Center (MMC) management type 2 diabetic mellitus (T2DM). Methods A total 2000 euthyroid participants from MMC Shanghai General Hospital a community physical examination were recruited. They categorized into four groups: normal tolerance (NGT, n = 132), prediabetes (N 147), DM well‐controlled (T2DM with glycosylated hemoglobin...
With the popularity and development of Internet Things (IoT) technology, human activity recognition using IoT devices such as wearable sensors can be implemented for various applications. Due to complexity recognition, multiple homogeneous or heterogeneous are used obtain excessive information in most systems. However, increased number way multichannel signal data bring huge challenges tasks. How select suitable sensor channels balance computational accuracy has become a major issue. In this...