A5018808214- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Pituitary Gland Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Immunotherapy and Biomarkers
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Meningioma and schwannoma management
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Neurosurgical Procedures and Complications
- Circular RNAs in diseases
- Magnesium Alloys: Properties and Applications
- Advanced Optical Sensing Technologies
- Immunotherapy and Immune Responses
- Neurogenesis and neuroplasticity mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- S100 Proteins and Annexins
- Optical measurement and interference techniques
Second Affiliated Hospital of Zhejiang University
2021-2025
Tongji University
2020-2024
Tongji Hospital
2024
Tsinghua University
2020-2022
Shanghai Jiao Tong University
2018-2022
Zhejiang University
2020-2022
Ruijin Hospital
2022
Shanghai First People's Hospital
2019-2021
University School
2020-2021
Tsinghua–Berkeley Shenzhen Institute
2020-2021
Background: Lactate greatly contributes to the regulation of intracellular communication within tumor microenvironment (TME). However, role lactate in pituitary adenoma (PA) invasion is unclear. In this study, we aimed clarify effects on TME and PA invasion. Methods: To explore correlation between acidosis invasion, LDHA LAMP2 expression levels were quantified invasive (n = 32) noninvasive samples. The immune cell infiltration was evaluated 64 PAs. Critical chemokine key signaling pathway...
Abstract Planar digital image sensors facilitate broad applications in a wide range of areas 1–5 , and the number pixels has scaled up rapidly recent years 2,6 . However, practical performance imaging systems is fundamentally limited by spatially nonuniform optical aberrations originating from imperfect lenses or environmental disturbances 7,8 Here we propose an integrated scanning light-field sensor, termed meta-imaging to achieve high-speed aberration-corrected three-dimensional...
Neuroinflammation and blood coagulation responses in cerebrospinal fluid (CSF) contribute to the poor outcome associated with subarachnoid haemorrhage (SAH). We explored role of caspase-1-mediated inflammasome activation on extrinsic CSF after SAH.Post-SAH proteomic changes correlation between caspase-1 factors human SAH were analysed. Time course cell localisation brain proteins a rat model. Pharmacological inhibition via VX-765 was used explore clearance circulation rats. Primary...
Abstract Subarachnoid hemorrhage (SAH) is a devastating subtype of stroke with high mortality and disability rate. Meningeal lymphatic vessels (mLVs) are newly discovered intracranial fluid transport system proven to drain extravasated erythrocytes from cerebrospinal into deep cervical lymph nodes after SAH. However, many studies have reported that the structure function mLVs injured in several central nervous diseases. Whether SAH can cause injury underlying mechanism remain unclear....
The regulatory mechanisms by which cholesterol influences hair regeneration remain incompletely understood. This study investigates the effects of on follicle stem cells (HFSCs) proliferation and regeneration, with a focus underlying molecular mechanisms. Subcutaneous injections in C57BL/6 mice significantly enhanced promoting HFSCs proliferation. Hematoxylin eosin (HE) staining revealed greater number follicles anagen phase cholesterol-treated group compared to controls. Immunofluorescence...
Glioma is one of the most typical intracranial tumors, comprising about 80% all brain malignancies. Several key molecular signatures have emerged as prognostic biomarkers, which indicate room for improvement in current approach to glioma classification. In order construct a more veracious prediction model and identify potential prognosis-biomarker, we explore differential expressed m6A RNA methylation regulators 665 gliomas from TCGA-GBM TCGA-LGG. Consensus clustering was applied regulators,...
Non-line-of-sight (NLOS) imaging reveals hidden objects reflected from diffusing surfaces or behind scattering media. NLOS reconstruction is usually achieved by computational deconvolution of time-resolved transient data a scanning single-photon avalanche diode (SPAD) detection system. However, using such system requires lengthy acquisition, impossible for capturing dynamic scenes. We propose to use novel SPAD array and an optimization-based method achieve 20 frames per second (fps). The...
The role of glial scar after intracerebral hemorrhage (ICH) remains unclear. This study aimed to investigate whether microglia-astrocyte interaction affects formation and explore the specific function scar. We used a pharmacologic approach induce microglial depletion during different ICH stages examine how ablating microglia astrocytic formation. Spatial transcriptomics (ST) analysis was performed potential ligand-receptor pair in modulation verify functional changes scars at periods. During...
Abstract Exercise benefits M2 macrophage polarization, energy homeostasis and protects against obesity partially through exercise-induced circulating factors. Here, by unbiased quantitative proteomics on serum samples from sedentary exercised mice, we identify parvalbumin as a factor suppressed exercise. Parvalbumin functions non-competitive CSF1R antagonist to inhibit activation expenditure in adipose tissue. More importantly, concentrations of positively correlate with mouse human, while...
Early severe cerebral edema and chronic hydrocephalus are the primary cause of poor prognosis in patients with subarachnoid hemorrhage (SAH). This study investigated role cerebrospinal fluid (CSF) inflammatory cytokines coagulation factors development SAH.
Background and purpose C-C motif chemokine ligand 17 (CCL17) presents an important role in immune regulation, which is critical the pathophysiology of brain injury after subarachnoid haemorrhage (SAH). There rare evidence to illustrate function CCL17 towards SAH. In this study, we try reveal therapeutic effects its underlying mechanism rat SAH model. Methods models were assigned receive recombinant (rCCL17) or phosphate buffer saline (PBS). AZD2098 JR-AB2-011 applied investigate receptor 4...
Stroke is the most common cerebrovascular disease and one of leading causes death disability worldwide. The current conventional treatment for stroke involves increasing cerebral blood flow reducing neuronal damage; however, there are no particularly effective therapeutic strategies rehabilitation after damage. Therefore, an urgent need to identify a novel alternative therapy stroke. Acupuncture has been applied in China 3000 years widely utilized diseases. Accumulating evidence revealed...
Abstract Purpose Glioma is the most prevalent malignant form of brain tumors, with a dismal prognosis. Currently, cancer immunotherapy has emerged as revolutionary treatment for patients advanced highly aggressive therapy-resistant tumors. However, there no effective biomarker to reflect response in glioma patient so far. So we aim assess clinical predictive value FCER1G glioma. Methods The expression level and correlation between prognosis FER1G levels were analyzed data from CGGA, TCGA,...
Background Glioma is a fatal tumor originating from the brain, which accounts for most intracranial malignancies. Currently, Immunotherapy has turned into novel and promising treatment in glioma patients. however, there are still few effective biomarkers to mirror reaction immunotherapy patients with glioma. Therefore, we intended elucidate evaluable efficacy of SLC11A1 Methods In this study, samples Shanghai General Hospital data TCGA, GEO, CGGA datasets were used investigate validate...
Improving the comprehensive performance of low alloyed Mg is a significant challenge for biomedical applications. This paper developed high-performance Mg-Zn alloy with uniform ultrafine grains and nano-precipitates through straightforward, high-temperature reciprocating equal channel angle extrusion (ECAP) process researched microstructure, mechanical property, degradation behaviour, biocompatibility alloy. Results showed that lean Mg-2Zn successfully refined grain to about 1 μm produced...