A5016694593- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Sinusitis and nasal conditions
- Trigeminal Neuralgia and Treatments
- Spinal Fractures and Fixation Techniques
- Vascular Malformations Diagnosis and Treatment
- Cervical and Thoracic Myelopathy
- Bone Tumor Diagnosis and Treatments
- Autophagy in Disease and Therapy
- Proteoglycans and glycosaminoglycans research
- Facial Nerve Paralysis Treatment and Research
- Oral and Maxillofacial Pathology
- Cell Adhesion Molecules Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Enzyme Catalysis and Immobilization
- RNA modifications and cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Craniofacial Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Microbial Metabolic Engineering and Bioproduction
- Botulinum Toxin and Related Neurological Disorders
Shanghai Tenth People's Hospital
2008-2025
Tongji University
2008-2025
Stanford University
2020-2025
Stanford Health Care
2024-2025
Oil Crops Research Institute
2024-2025
Chinese Academy of Agricultural Sciences
2024-2025
Ministry of Agriculture & Farmers Welfare
2025
Fudan University
2021-2024
Huashan Hospital
2021-2024
First Affiliated Hospital of Zhengzhou University
2023-2024
Background: Lactate greatly contributes to the regulation of intracellular communication within tumor microenvironment (TME). However, role lactate in pituitary adenoma (PA) invasion is unclear. In this study, we aimed clarify effects on TME and PA invasion. Methods: To explore correlation between acidosis invasion, LDHA LAMP2 expression levels were quantified invasive (n = 32) noninvasive samples. The immune cell infiltration was evaluated 64 PAs. Critical chemokine key signaling pathway...
Positive associations between periodontitis (PD) and atherosclerosis have been established, but the causality mechanisms are not clear. We aimed to explore causal roles of PD in dissect underlying mechanisms.A mouse model was established by ligation molars combination with application subgingival plaques collected from patients then combined induced treating atheroprone mice a high-cholesterol diet (HCD). significantly aggravated HCD-fed mice, including increased en face plaque areas whole...
Glioma is one of the most typical intracranial tumors, comprising about 80% all brain malignancies. Several key molecular signatures have emerged as prognostic biomarkers, which indicate room for improvement in current approach to glioma classification. In order construct a more veracious prediction model and identify potential prognosis-biomarker, we explore differential expressed m6A RNA methylation regulators 665 gliomas from TCGA-GBM TCGA-LGG. Consensus clustering was applied regulators,...
Abstract As an important part of tumor microenvironment, neutrophils are poorly understood due to their spatiotemporal heterogeneity in tumorigenesis. Here we defined, at single-cell resolution, CD44 −CXCR2 − as tumor-specific (tsNeus) both mouse and human gastric cancer (GC). We uncovered a Hippo regulon with unique YAP signature genes (e.g., ICAM1, CD14, EGR1) distinct from those identified epithelial and/or cells. Importantly, knockout YAP/TAZ neutrophiles impaired differentiation into...
The striatin-interacting phosphatase and kinase (STRIPAK) complexes integrate extracellular stimuli that result in intracellular activities. Previously, we discovered STRIPAK is a key machinery responsible for loss of the Hippo tumor suppressor signal cancer. Here, identified Hippo-STRIPAK complex as an essential player control DNA double-stranded break (DSB) repair genomic stability. Specifically, found mammalian STE20-like protein kinases 1 2 (MST1/2), independent classical signaling,...
Glioma is a severe disease of the central nervous system. Although previous studies have identified important role immune response in association with tumor intervention, it still unknown whether PU.1, transcription factor known for its myeloid differentiation and responses, involved progression glioma. In present study, we found significant increase SPI1, gene that encodes samples from patients Through genotype‑phenotype analysis several candidate factors may mediate PU.1 glioma were...
Background Glioma is a fatal tumor originating from the brain, which accounts for most intracranial malignancies. Currently, Immunotherapy has turned into novel and promising treatment in glioma patients. however, there are still few effective biomarkers to mirror reaction immunotherapy patients with glioma. Therefore, we intended elucidate evaluable efficacy of SLC11A1 Methods In this study, samples Shanghai General Hospital data TCGA, GEO, CGGA datasets were used investigate validate...
ABSTRACT Particulate matter with aerodynamic diameter ≤ 2.5 μm (PM ) at high concentrations in dental clinics poses significant health risks to healthcare professionals. However, the morphology and chemical composition of PM specific environments are not yet fully elucidated. In this study, we investigated concentration, morphology, composition, assessment collected a multi‐chair clinic Shanghai, China. Scanning electron microscopy (SEM) energy‐dispersive X‐ray spectroscopy (EDS) were...