A5002163416- Extracellular vesicles in disease
- Cell Adhesion Molecules Research
- Pituitary Gland Disorders and Treatments
- Advanced biosensing and bioanalysis techniques
- Glioma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Head and Neck Surgical Oncology
- Nanoparticle-Based Drug Delivery
- Caveolin-1 and cellular processes
- RNA Interference and Gene Delivery
- Cerebrospinal fluid and hydrocephalus
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Radiopharmaceutical Chemistry and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Soft tissue tumor case studies
- Anesthesia and Neurotoxicity Research
- Supramolecular Self-Assembly in Materials
Cedars-Sinai Medical Center
2015-2025
Stanford University
2024-2025
Stanford Health Care
2025
University of South Florida
2017-2021
University at Buffalo, State University of New York
2017
University of Southern California
2015-2016
Abstract Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was largely unsuccessful due their inability cross blood–brain barrier (BBB). Here we describe targeted nanoscale immunoconjugates (NICs) on natural biopolymer scaffold, poly(β-L-malic acid), covalently attached a-CTLA-4 or a-PD-1 for systemic delivery across the BBB activation of local brain anti-tumor immune response. NIC mice...
Adult neurogenesis in the subgranular zone of hippocampus is involved learning, memory, and mood control. Decreased hippocampal elicits significant behavioral changes, including cognitive impairment depression. Inflammatory bowel disease (IBD) a group chronic inflammatory conditions intestinal tract, dysfunction depression frequently occur patients suffering from this disorder. We therefore tested effects inflammation on neurogenesis.The dextran sodium sulfate (DSS) mouse model IBD was used....
Weekly glatiramer acetate immunization of transgenic mice modelling Alzheimer's disease resulted in retained cognition (Morris water maze test), decreased amyloid-β plaque burden, and regulation local inflammation through a mechanism involving enhanced recruitment monocytes. Ablation bone marrow-derived myeloid cells exacerbated pathology, whereas weekly administration cerebral innate immune cells, which dampened the pathology. Here, we assessed therapeutic potential grafted CD115+...
Significance Growth hormone (GH) excess in acromegaly is associated with increased colon polyps and cancer, whereas short-stature humans harboring a GH receptor mutation do not develop cancer. Administration of blocker patients induced p53. In contrast, p53 suppressed by cells, vivo tissue, pluripotent stem cell-derived intestinal organoids. leads to cell survival downregulated adenomatous polyposis coli, nuclear β-catenin accumulation, epithelial–mesenchymal transition factors. Because...
Differential diagnosis of brain magnetic resonance imaging (MRI) enhancement(s) remains a significant problem, which may be difficult to resolve without biopsy, can often dangerous or even impossible. Such MRI result from metastasis primary tumors such as lung breast, radiation necrosis, infections, new tumor (glioma, meningioma). Neurological symptoms are the same on initial presentation. To develop more precise noninvasive diagnostic method, we have engineered class poly(β-l-malic acid)...
There is an unmet need for the treatment of glioblastoma multiforme (GBM). The extracellular matrix, including laminins, in tumor microenvironment important invasion and progression. In a panel 226 patient brain glioma samples, we found clinical correlation between expression vascular laminin-411 (α4β1γ1) with higher grade cancer stem cell (CSC) markers, Notch pathway members, CD133, Nestin, c-Myc. Laminin-411 overexpression also correlated recurrence rate shorter survival GBM patients. We...
Delivery of therapeutic substances into the brain poses a significant challenge in treatment neurological disorders. This is primarily due to blood-brain barrier (BBB), which restricts access, alongside limited stability and distribution these agents within tissue. Here we demonstrate an efficient delivery microRNA (miRNA) antisense RNA preferentially neurons compared astroglia healthy Alzheimer's disease mice, via disulfide-linked conjugation with poly(ß-L-malic acid-trileucine)-copolymer...
Altered neurogenesis in adult hippocampus is implicated cognition impairment and depression. Inflammation a potent inhibitor of neurogenesis. The cyclin-dependent kinase p21(Cip1) (p21) restrains cell cycle progression arrests the G1 phase. We recently showed that p21 expressed neuronal progenitors regulates proliferation these cells subgranular zone dentate gyrus where occurs. current study suggests induced vivo WT mice response to acute systemic inflammation caused by LPS injections,...
Glioblastoma multiforme (GBM) remains the deadliest brain tumor in adults. GBM tumors are also notorious for drug and radiation resistance. To inhibit GBMs more effectively, polymalic acid-based blood-brain barrier crossing nanobioconjugates were synthesized that delivered to cytoplasm of cancer cells specifically master regulator serine/threonine protein kinase CK2 wild-type/mutated epidermal growth factor receptor (EGFR/EGFRvIII), which overexpressed gliomas according The Cancer Genome...
Abstract BACKGROUND Understanding how many patients are eligible for endovascular therapy can help develop more effective stroke systems of care. OBJECTIVE To determine the proportion therapy. METHODS In this single center retrospective cohort study, we identified with acute ischemic from large vessel occlusion (LVO) January 2014 to December 2015. Selection criteria including LVO location, Alberta program early computed tomography score (ASPECTS) range, hospital arrival time, and use...
BACKGROUND AND OBJECTIVES: To address the lack of a multicenter pituitary surgery research consortium in United States, we established Registry Adenomas Pituitary and Related Disorders (RAPID). The goals RAPID are to examine surgical outcomes, improve patient care, disseminate best practices, facilitate at scale. Our initial focus is Cushing disease (CD). This study aims describe current cohort, explore lay foundation for future studies addressing limitations previous studies. METHODS:...
INTRODUCTION: Glioblastomas (GBM) escape the immune system and are heterogenous making it difficult to target tumor directly for treatment. However, microenvironment is independent of glioma heterogeneity might be a universal target. GBMs overexpressing laminin-411 associated with poor patient survival. We synthesized blood brain barrier (BBB) crossing drug delivery that can selectively inhibit synthesis in vivo, upregulating innate improving METHODS: GBM cell lines CT-2A GL261 CRISPR/Cas9...
Abstract Pituitary tumors grow slowly and despite their high prevalence are invariably benign. We therefore studied mechanisms underlying pituitary tumor growth restraint. transforming gene (PTTG), the index human securin, a hallmark of tumors, triggers cell proliferation murine development. show that gonadotroph unlike other secreting types, express levels gonadotroph-specific forkhead transcription factor FOXL2, both PTTG Forkhead box protein L2 (FOXL2) stimulate clusterin (Clu)...
Abstract Context Postoperative hyponatremia leads to prolonged hospital length of stay and readmission within 30 days. Objective To assess 3 strategies for reducing rates postoperative analyze risk factors hyponatremia. Design Two retrospective analyses 1 prospective study. Setting Tertiary referral hospital. Patients undergoing transsphenoidal surgery pituitary adenomas other sellar parasellar pathologies. Intervention(s) Phase 1: no intervention. 2: day (POD) 7 sodium testing patient...