A5029621910- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Pharmacological Receptor Mechanisms and Effects
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Virus-based gene therapy research
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Bipolar Disorder and Treatment
- Cancer-related cognitive impairment studies
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Treatment of Major Depression
- Anesthesia and Neurotoxicity Research
- Glioma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Memory and Neural Mechanisms
- Epigenetics and DNA Methylation
- Attention Deficit Hyperactivity Disorder
Western University of Health Sciences
2013-2025
Cedars-Sinai Medical Center
2000-2013
University of California, Los Angeles
1987-2013
Neurobehavioral Systems
2013
Louisiana State University Health Sciences Center New Orleans
2000
Louisiana State University
1993-1997
University Medical Center New Orleans
1993-1995
Harbor–UCLA Medical Center
1985-1986
UCLA Medical Center
1985-1986
University of California San Diego Medical Center
1981
Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and widespread cortical neuronal loss (Selkoe, 2001). The "amyloid cascade hypothesis" posits that cerebral sets neurotoxic events into motion precipitate Alzheimer dementia (Hardy Allsop, 1991). Yet, faithful recapitulation of all AD features in widely used transgenic (Tg) mice engineered to overproduce Aβ peptides has been elusive. We have developed a Tg rat model (line TgF344-AD) expressing mutant human...
We previously reported that a single systemic injection of high dose morphine (greater than or equal to 20 mg/kg) transiently suppresses splenic natural killer cell cytotoxicity in rats. The present study examined the possibility immune-suppressive effect is mediated by opiate receptors brain. Supporting this hypothesis, we found (20 40 micrograms) injected into lateral ventricle suppressed activity same degree as higher three orders magnitude. This was blocked an antagonist, naltrexone....
Adult neurogenesis in the subgranular zone of hippocampus is involved learning, memory, and mood control. Decreased hippocampal elicits significant behavioral changes, including cognitive impairment depression. Inflammatory bowel disease (IBD) a group chronic inflammatory conditions intestinal tract, dysfunction depression frequently occur patients suffering from this disorder. We therefore tested effects inflammation on neurogenesis.The dextran sodium sulfate (DSS) mouse model IBD was used....
The subgranular zone (SGZ) of the dentate gyrus hippocampus is a brain region where robust neurogenesis continues throughout adulthood. Cyclin-dependent kinases (CDKs) have primary role in controlling cell division and cellular proliferation. p21(Cip1) (p21) CDK inhibitor that restrains cycle progression. Confocal microscopy revealed p21 abundantly expressed nuclei cells SGZ colocalized with NeuN, marker for neurons. Doublecortin (DCX) cytoskeletal protein primarily by neuroblasts. By using...
The relationships among hippocampal neurogenesis, depression and the mechanism of action antidepressant drugs have generated a considerable amount controversy. cyclin-dependent kinase (Cdk) inhibitor p21Cip1 (p21) plays crucial role in restraining cellular proliferation maintaining quiescence. Using vivo vitro approaches present study shows that p21 is expressed subgranular zone dentate gyrus hippocampus early neuronal progenitors immature neurons, but not mature neurons or astroglia. In...
Altered neurogenesis in adult hippocampus is implicated cognition impairment and depression. Inflammation a potent inhibitor of neurogenesis. The cyclin-dependent kinase p21(Cip1) (p21) restrains cell cycle progression arrests the G1 phase. We recently showed that p21 expressed neuronal progenitors regulates proliferation these cells subgranular zone dentate gyrus where occurs. current study suggests induced vivo WT mice response to acute systemic inflammation caused by LPS injections,...
Cerebral (Aβ) plaque and (pTau) tangle deposition are hallmarks of Alzheimer’s disease (AD), yet insufficient to confer complete AD-like neurodegeneration experimentally. Factors acting upstream Aβ/pTau in AD remain unknown, but their identification could enable earlier diagnosis more effective treatments. T cell abnormalities emerging hallmarks, CD8 cells were recently found mediate downstream hereditary models. The precise impact Aβ/pTau, however, appears vary depending on the animal...
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in humans. Systemic immunity against gene therapy vectors has been shown to hamper therapeutic efficacy; however, helper-dependent high-capacity adenovirus (HC-Ad) elicit sustained transgene expression, even presence of systemic anti-adenoviral immunity. We engineered HC-Ads encoding conditional cytotoxic herpes simplex type 1 thymidine kinase (TK) immunostimulatory cytokine fms-like tyrosine ligand 3...
The effects of the systemic administration three prototypic multiple opiate receptor agonists, morphine sulfate (MS), ethylketocyclazocine methanesulfonate (EKC) and N-allylnormetazocine hydrochloride (NANMT), on release anterior pituitary hormones were studied in rat. serum levels corticosterone, growth hormone, prolactin luteinizing hormone measured by radioimmunoassay 30 min after s.c. injection drugs. compounds elicited different patterns four hormones. MS, EKC NANMT rises corticosterone...
Glioblastoma multiforme (GBM) is an invasive and aggressive primary brain tumor which associated with a dismal prognosis. We have earlier developed macroscopic, intracranial, syngeneic GBM model, in treatment adenoviral vectors (Ads) expressing herpes simplex virus type 1 thymidine kinase (HSV1-TK) plus ganciclovir (GCV) resulted survival of ∼20% the animals. In this Ads Fms-like tyrosine 3 ligand (Flt3L), combination Ad-HSV1-TK improves rate to ∼70% induces systemic antitumor immunity....
ABSTRACT Glioblastoma multiforme (GBM) is a deadly primary brain tumor. Conditional cytotoxic/immune-stimulatory gene therapy (Ad-TK and Ad-Flt3L) elicits tumor regression immunological memory in rodent GBM models. Since the majority of patients enrolled clinical trials would exhibit adenovirus immunity, which could curtail transgene expression therapeutic efficacy, we used high-capacity vectors (HC-Ads) as delivery platform. Herein, describe for first time novel bicistronic HC-Ad driving...
T-lymphocytes have been previously implicated in protecting dopaminergic neurons the substantianigra from induced cell death. However, role of T-cells neurodegenerative models such as Parkinson's disease (PD) has not fully elucidated. To examine on motor behavior 6-hydroxydopamine (6-OHDA) unilateral striatal partial lesion PD rat model, we assessed progression hemi-parkinsonian lesions substantia nigra, by 6-OHDA injections, athymic rats (RNU-/-, T-lymphocyte-deficient) compared to RNU-/+...