Login

Alireza Salem

ORCID: 0009-0007-3895-7667
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
A5102768650
Research Areas
  • Virus-based gene therapy research
  • RNA Interference and Gene Delivery
  • CAR-T cell therapy research
  • Head and Neck Anomalies
  • Herpesvirus Infections and Treatments
  • Oral and Maxillofacial Pathology
  • interferon and immune responses
  • Salivary Gland Tumors Diagnosis and Treatment
  • S100 Proteins and Annexins
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms

University of Houston
 2024

Columbia University Irving Medical Center
 2024

Cedars-Sinai Medical Center
 2010-2013

 Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma
OPENALEX - Publications 
A.K.M. Ghulam Muhammad Mariana Puntel Marianela Candolfi Alireza Salem K Yagiz and 15 more Catherine Farrokhi Kurt M. Kroeger Wei Xiong James F. Curtin C. Liu Katherine E. Lawrence Niyati Bondale Jonathan Lerner Gregory J. Baker David Foulad Robert N. Pechnick Donna Palmer P Ng P R Lowenstein María G. Castro

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in humans. Systemic immunity against gene therapy vectors has been shown to hamper therapeutic efficacy; however, helper-dependent high-capacity adenovirus (HC-Ad) elicit sustained transgene expression, even presence of systemic anti-adenoviral immunity. We engineered HC-Ads encoding conditional cytotoxic herpes simplex type 1 thymidine kinase (TK) immunostimulatory cytokine fms-like tyrosine ligand 3...

10.1038/clpt.2009.260 article EN Clinical Pharmacology & Therapeutics 2010-02-17
 A Novel Bicistronic High-Capacity Gutless Adenovirus Vector That Drives Constitutive Expression of Herpes Simplex Virus Type 1 Thymidine Kinase and Tet-Inducible Expression of Flt3L for Glioma Therapeutics
OPENALEX - Publications 
Mariana Puntel A.K.M. Ghulam Muhammad Marianela Candolfi Alireza Salem Kader Yagiz and 12 more Catherine Farrokhi Kurt M. Kroeger Weidong Xiong James F. Curtin Chunyan Liu Niyati Bondale Jonathan Lerner Robert N. Pechnick Donna Palmer Philip Ng Pedro R. Löwenstein María G. Castro

ABSTRACT Glioblastoma multiforme (GBM) is a deadly primary brain tumor. Conditional cytotoxic/immune-stimulatory gene therapy (Ad-TK and Ad-Flt3L) elicits tumor regression immunological memory in rodent GBM models. Since the majority of patients enrolled clinical trials would exhibit adenovirus immunity, which could curtail transgene expression therapeutic efficacy, we used high-capacity vectors (HC-Ads) as delivery platform. Herein, describe for first time novel bicistronic HC-Ad driving...

10.1128/jvi.00398-10 article EN Journal of Virology 2010-04-08
 222 Clinicopathological Features of Neutrophil-Rich Breast Carcinoma
OPENALEX - Publications 
Alireza Salem Diane Chen H.C. ELLSWORTH Hanina Hibshoosh Fatemeh Derakhshan

10.1016/j.labinv.2024.102446 article EN Laboratory Investigation 2025-03-01
 Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma
OPENALEX - Publications 
Mariana Puntel Ghulam Muhammad A.K.M. Catherine Farrokhi Nathan VanderVeen Christopher Paran and 14 more Ashley Appelhans Kurt M. Kroeger Alireza Salem Liliana Lacayo Robert N. Pechnick Kyle R. Kelson Sukhpreet Kaur Sean P. Kennedy Donna Palmer Philip Ng Chunyan Liu Johnny Krasinkiewicz Pedro R. Löwenstein María G. Castro

10.1016/j.taap.2013.02.001 article EN Toxicology and Applied Pharmacology 2013-02-09
 Safety Profile of Gutless Adenovirus Vectors Delivered into the Normal Brain Parenchyma: Implications for a Glioma Phase 1 Clinical Trial
OPENALEX - Publications 
A.K.M. Ghulam Muhammad Weidong Xiong Mariana Puntel Catherine Farrokhi Kurt M. Kroeger and 9 more Alireza Salem Liliana Lacayo Robert N. Pechnick Kyle R. Kelson Donna Palmer Philip Ng Chunyan Liu Pedro R. Löwenstein María G. Castro

Adenoviral vectors (Ads) have been evaluated in clinical trials for glioma. However, systemic immunity against the can hamper therapeutic efficacy. We demonstrated that combined immunostimulation and cytotoxic gene therapy provides long-term survival preclinical glioma models. Because helper-dependent high-capacity Ads (HC-Ads) elicit sustained transgene expression, presence of antiadenoviral immunity, we engineered HC-Ads encoding conditional herpes simplex type 1 thymidine kinase...

10.1089/hgtb.2012.060 article EN Human Gene Therapy Methods 2012-08-01
 Impact of NOTCH1 expression in primary breast adenoid cystic carcinoma
OPENALEX - Publications 
Alireza Salem Yun Wu Qingqing Ding Lavinia P. Middleton

Adenoid cystic carcinoma (AdCC) originates from salivary-type like glands in the head and neck, lung, breast. AdCC shows chromosomal translocation, resulting

10.1136/jcp-2023-209325 article EN cc-by Journal of Clinical Pathology 2024-03-12
Coming Soon ...