Weikang Wu

ORCID: 0000-0002-5821-2474
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About
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Research Areas
  • Epigenetics and DNA Methylation
  • Urinary Tract Infections Management
  • Urinary Bladder and Prostate Research
  • Immune cells in cancer
  • Immune responses and vaccinations
  • Hepatitis C virus research
  • Hepatitis B Virus Studies
  • Proteoglycans and glycosaminoglycans research
  • Fatty Acid Research and Health
  • Immune Response and Inflammation
  • Liver Disease Diagnosis and Treatment
  • Immunotherapy and Immune Responses
  • Viral Infections and Vectors
  • Prostate Cancer Treatment and Research
  • Influenza Virus Research Studies
  • Birth, Development, and Health
  • Cancer, Lipids, and Metabolism
  • Renal cell carcinoma treatment
  • Urological Disorders and Treatments
  • Cholesterol and Lipid Metabolism
  • Mosquito-borne diseases and control
  • Ferroptosis and cancer prognosis

Anhui Medical University
2024-2025

First Affiliated Hospital of Anhui Medical University
2024-2025

Air Force Medical University
2022-2023

Gansu University of Traditional Chinese Medicine
2022-2023

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common disorder associated with voiding symptoms and in the or perineal area. Macrophages, particularly pro-inflammatory M1 subtype, are crucial initiating of CP/CPPS. Interferon regulatory factor 7 (Irf7) has been implicated promoting polarization, contributing to onset progression autoimmunity. However, role Irf7 etiology CP/CPPS remains unclear. We established experimental autoimmune prostatitis (EAP) mouse model by...

10.1007/s00018-025-05608-w article EN cc-by-nc-nd Cellular and Molecular Life Sciences 2025-02-22

Abstract Chronic prostatitis and Pelvic Pain syndrome (CP/CPPS) is an autoimmune inflammatory disease characterized by pelvic or perineal pain infiltration of cells in the prostate. C-X-C chemokine receptor type 7 (CXCR7), also known as atypical 3 (ACKR3) receptor, are receptors. Having been shown to play a key role processes, whether CXCR7 influences prostate immune regulation its mechanism action unclear. In this study, mouse model experimental was constructed subcutaneous injection...

10.21203/rs.3.rs-4186657/v1 preprint EN cc-by Research Square (Research Square) 2024-04-03

<title>Abstract</title> Centromere protein W (CENP-W) is essential for chromosome segregation and mitotic assembly has been recognized as a prognostic marker in several cancers. However, its significance clear-cell renal cell carcinoma (ccRCC) remains underexplored. To address this, we analyzed ccRCC transcriptomic data from the National Center Biotechnology Information (NCBI) The Cancer Genome Atlas (TCGA) to evaluate CENP-W expression associations with clinical outcomes, prognosis,...

10.21203/rs.3.rs-5255400/v1 preprint EN 2024-10-28

<title>Abstract</title> <bold>Background</bold>: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common disorder associated with voiding symptoms and in the or perineal area. Macrophages, particularly pro-inflammatory M1 subtype, are crucial initiation of CP/CPPS. Interferon regulatory factor 7 (Irf7) has been implicated promoting polarization, which contributes to onset progression autoimmunity. However, role Irf7 etiology CP/CPPS remains unclear. <bold>Method: </bold>We...

10.21203/rs.3.rs-5284649/v1 preprint EN cc-by Research Square (Research Square) 2024-11-04

<title>Abstract</title> <bold>Objective and design:</bold>Prdx5 is a member of the thiol-dependent peroxidase superfamily with activity. Previous studies have demonstrated that Prdx5 involved in development inflammatory arthritis. However, role apoptosis within chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) remains unclear. To elucidate prostatitis its underlying mechanisms. <bold>Material: </bold>Constructed experimental autoimmune conducted macrophage cell experiments....

10.21203/rs.3.rs-4900531/v1 preprint EN Research Square (Research Square) 2024-09-09

Background and aim Chronic hepatitis B (CHB) can be divided into immune tolerance (IT), clearance (IC), e antigen (HBeAg)-negative inactive/quiescent carrier (ENQ), HBeAg-negative (ENH) phases. The conventional biomarkers used to distinguish these phases have limitations. We examined the clinical significance of virus (HBV) RNA core-related (HBcrAg) as novel biomarkers. Methods One hundred eighty-nine patients without treatment currently were categorized by CHB phase (IT = 46, IC 45, ENQ 49,...

10.3389/fpubh.2022.1037508 article EN cc-by Frontiers in Public Health 2022-10-28

Three highly pathogenic avian influenza (H5N8) viruses were detected in the migratory bird Podiceps nigricollis Northwest China June 2021. Phylogenetic analysis indicated that these H5N8 isolates belonged to clade 2.3.4.4b, which homologous strains isolated and South Korea. In this study, virus infection was using Oxford Nanopore Technologies sequencing technology caused pathological changes multiple organs.

10.1155/2023/7896376 article EN cc-by Transboundary and Emerging Diseases 2023-02-21
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