A5100394975- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Erythrocyte Function and Pathophysiology
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Vector-Borne Animal Diseases
- Epigenetics and DNA Methylation
- Metal-Organic Frameworks: Synthesis and Applications
- Animal Disease Management and Epidemiology
- Urinary Bladder and Prostate Research
- Reproductive System and Pregnancy
- Urinary Tract Infections Management
- Cancer Immunotherapy and Biomarkers
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- Oxidative Organic Chemistry Reactions
- Environmental Conservation and Management
- Lymphoma Diagnosis and Treatment
- Gaze Tracking and Assistive Technology
- Conservation, Biodiversity, and Resource Management
- COVID-19 Impact on Reproduction
- Galectins and Cancer Biology
First Affiliated Hospital of Gannan Medical University
2022-2025
Sichuan University
2022-2025
State Key Laboratory of Oral Diseases
2022-2025
First Affiliated Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2024-2025
Hainan University
2025
Affiliated Hospital of Guizhou Medical University
2021-2024
Guizhou University
2024
The First People's Hospital of Changzhou
2023
Soochow University
2023
Abstract Macrophage-mediated programmed cell removal (PrCR) is a process essential for the clearance of unwanted (damaged, dysfunctional, aged, or harmful) cells. The detection and recognition appropriate target cells by macrophages critical step successful PrCR, but its molecular mechanisms have not been delineated. Here using models tissue turnover, cancer immunosurveillance, hematopoietic stem cells, we show that such as aging neutrophils living are susceptible to “labeling” secreted...
// Tiansuo Zhao 1,* , He Ren Li Jia 2 Jing Chen 1 Wen Xin Fan Yan Xiuchao Wang Song Gao Dong Qian Chongbiao Huang and Jihui Hao Tianjin Medical University Cancer Institute Hospital, National Clinical Research Center for Cancer, Key Laboratory of Prevention Therapy, Department Pancreatic Tianjin, China Centre Haemato-Oncology, Barts Institute, Queen Mary London, UK * These authors contributed equally to this work Correspondence: Hao, email: Keywords : ductal adenocarcinoma (PDAC), Immunogenic...
Article7 December 2020Open Access Source Data Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer Weiqiang Lu Corresponding Author [email protected] orcid.org/0000-0003-1349-6597 Shanghai Key Laboratory of Regulatory Biology, Institute Biomedical Sciences and School Life Sciences, East China Normal University, Shanghai, ChinaThese authors contributed equally to this work. Search more papers by author Weiwei Yu Jiacheng He Wenjuan Liu Junjie Yang...
Rationale: Tumor-associated macrophages (TAMs), generally displaying the pro-tumor M2-like phenotype, strongly influence progression of colorectal cancer (CRC) via their immunosuppressive activities. The high-mobility gene group A2 (HMGA2), an oncoprotein, is aberrantly overexpressed in CRC cells. However, mechanisms by which tumor-derived HMGA2 modulates tumor microenvironment remain poorly understood. Methods:In vivo subcutaneous xenograft model, azoxymethane (AOM)/dextran sodium sulfate...
Abstract Overcoming local immunosuppression is critical for immunotherapy to produce robust anti-tumor responses. Myeloid-derived suppressor cells (MDSCs) are key regulators of immunosuppressive networks and promote tumor progression. However, it remains unclear whether how tumor-infiltrating MDSCs shaped in response anti-PD-1 treatment what their impact on therapeutic efficacy colorectal cancer (CRC). In this study, the levels infiltrating were significantly higher non-responding organoids...
Background Limited therapeutic options are available for triple-negative breast cancer (TNBC), emphasizing an urgent need more effective treatment approaches. The development of strategies by targeting tumor-associated macrophages (TAMs) to stimulate their ability Programmed Cell Removal (PrCR) provides a promising new immunotherapy TNBC treatment. Methods CD47 is critical self-protective “don’t eat me” signal on multiple human cancers against macrophage immunosurveillance. Using and mouse...
CD47 is known to be involved in phagocyte-mediated tumor clearance; however, its expression, clinical significance, and regulatory mechanism hepatocellular carcinoma (HCC) remain poorly understood. In the present study, we found that upregulation of expression on cells was correlated with poor overall survival recurrence-free patients HCC. Abundance macrophages (Mφs) infiltration CD47+ tissues. Mechanistic studies revealed IL-6 derived from tumor-infiltrating Mφs could upregulate hepatoma...
Multiple myeloma (MM) is characterized by an accumulation of malignant plasma cells (PCs) within the BM. The BM microenvironment supports survival and composed cellular fractions that foster development progression suppression immune response. Despite major progress in understanding biology pathophysiology MM, this disease still incurable requires aggressive treatment with significant side effects. CD84 a self-binding immunoreceptor belonging to signaling lymphocyte activation molecule...
Evasion of immunosurveillance is critical for cancer initiation and development. The expression “don’t eat me” signals protects cells from being phagocytosed by macrophages, the blockade such demonstrates therapeutic potential restoring susceptibility to macrophage-mediated phagocytosis. However, whether additional self-protective mechanisms play a role against macrophage surveillance remains unexplored. Here, we derived macrophage-resistant model deficient in CD47, major signal, via...
Assessing the value of ecosystem products over time can reflect effectiveness protection and serve as a measurable indicator in national park management. This study focuses on Three-River-Source National Park (TRSNP), located Tibetan Plateau, “Water Tower China”. We developed an accounting system for TRSNP assessed their 2015 2020. Key findings include following. (1) The validation system’s scientific basis with comprehensive framework covering material products, regulating services,...
ABSTRACT Background and Aims Epoxide hydrolase 2 (EPHX2) regulates lipid signaling across various metabolites by encoding soluble epoxide hydrolase. However, its mechanisms implications in human malignancies remain unknown. This research aimed to detail the prognostic landscape of EPHX2 pan‐cancer explore potential relationship with immune infiltration tumor microenvironment. Methods Herein, multiple bioinformatics tools were used comprehensively evaluate expression, diagnostic, significance...
Abstract Metabolism is reprogrammed in cancer to fulfill the demands of malignant cells for initiation and progression. Apart from its effects within cells, little known about whether how reprogramed metabolism regulates surrounding tumor microenvironment (TME). Myeloid-derived suppressor (MDSC) are key regulators TME greatly affect progression therapeutic responses. In this study, our results revealed that retinol metabolism–related genes enzymes were significantly downregulated human...
Purpose: The aim of this study was to investigate how human immunodeficiency virus (HIV) affects cerebral cortex development in adolescent children, what are susceptible brain regions, and these structural changes correlate with cognitive abilities. Methods: We used magnetic resonance imaging examine gray matter volume cortical thickness 16 HIV-infected children (mean age = 13.63 years) 25 HIV-exposed uninfected 13.32 years), 12 them were subjected a one-year repetitive scan the brain. Five...
Abstract This paper investigates the negotiation of interpersonal relations by interpreters in Chinese government press conferences – a major instrument for promotion public diplomacy China. Drawing on theory linguistic modality systemic functional grammar (SFG) and concept explicitation ( Englund Dimitrova 1993 ), we present corpus-based discourse analysis interpreters’ connect it to their participation negotiating such setting. Quantitative results indicate noticeable trend explicit use...
Serpins are evolutionarily conserved serine protease inhibitors that widely distributed in animals, plants and microbes. In this study, we reported the cloning functional characterizations of two novel serpin genes, HlSerpin-a HlSerpin-b, from hard tick Haemaphysalis longicornis China. Recombinant HlSerpin-b displayed inhibitory activities against multiple mammalian proteases. Similar to other serpins, suppressed expression inflammatory cytokines such as TNF-α, interleukin (IL)-6 IL-1β...
BaP and DBP are ubiquitously contemporaneously present in the environment. However, Current studies largely concentrate on effects of a single pollutant (BaP or DBP). The liver is vital for biogenic activities. co-exposure remain unclear. Thus, we treated human normal cell (L02 cell) with or/and DBP. We found that compared to individual exposure, induced further increased levels AST ALT. caused IL-2, IL-6, TNF-α, decreased IL-10 level, higher percentage apoptotic cells S-phase arrest cells....