A5056010815- Supercapacitor Materials and Fabrication
- Advanced battery technologies research
- Advancements in Battery Materials
- Electrocatalysts for Energy Conversion
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- 2D Materials and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Advanced Proteomics Techniques and Applications
- Nuclear physics research studies
- Graphene research and applications
- Mass Spectrometry Techniques and Applications
- Regulation of Appetite and Obesity
- Nuclear Physics and Applications
- RNA modifications and cancer
- Atomic and Molecular Physics
- Proteins in Food Systems
- Cancer-related gene regulation
- Graphene and Nanomaterials Applications
- Quantum Dots Synthesis And Properties
- Advanced Radiotherapy Techniques
- Biochemical effects in animals
- MXene and MAX Phase Materials
Third Affiliated Hospital of Harbin Medical University
2020-2025
Harbin Medical University
2020-2025
Dalian Polytechnic University
2022-2024
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
2016-2023
Jilin University
2012-2023
Dalian Ocean University
2022-2023
University of Wisconsin–Madison
2013-2022
William S. Middleton Memorial Veterans Hospital
2017-2022
Harbin University of Science and Technology
2022
Harbin Institute of Technology
2022
We recently found that feeding healthy mice a diet with reduced levels of branched-chain amino acids (BCAAs), which are associated insulin resistance in both humans and rodents, modestly improves glucose tolerance slows fat mass gain. In the present study, we show BCAA promotes rapid loss without calorie restriction obese mice. Selective reduction dietary BCAAs also restores sensitivity to mice, even as they continue consume high-fat, high-sugar diet. A low transiently induces FGF21...
Hierarchical CoMoO<sub>4</sub>@NiMoO<sub>4</sub> core–shell nanosheet arrays synthesized <italic>via</italic> a two-step hydrothermal method with successive annealing exhibited outstanding electrochemical performance.
Abstract Rapamycin, an inhibitor of mechanistic Target Of Rapamycin Complex 1 (mTORC1), extends lifespan and shows strong potential for the treatment age-related diseases. However, rapamycin exerts metabolic immunological side effects mediated by off-target inhibition a second mTOR-containing complex, mTOR complex 2. Here, we report identification DL001, FKBP12-dependent analog 40x more selective mTORC1 than rapamycin. DL001 inhibits in cell culture lines vivo C57BL/6J mice, which signaling...
Obesity and diabetes are major challenges to global health, there is an urgent need for interventions that promote weight loss. Dietary restriction of methionine promotes leanness improves metabolic health in mice humans. However, poor long-term adherence this diet limits its translational potential. In study, we develop a short-term deprivation (MD) regimen preferentially reduces fat mass, restoring normal body glycemic control diet-induced obese both sexes. The benefits MD do not accrue...
Calorie restriction (CR) extends the healthspan and lifespan of diverse species. In mammals, a broadly conserved metabolic effect CR is improved insulin sensitivity, which may mediate beneficial effects diet. This model has been challenged by identification interventions that extend yet promote resistance. These include rapamycin, mouse induces resistance disrupting mTORC2 (mechanistic target rapamycin complex 2). Here, we induce genetically adipose via tissue-specific deletion component...
Tissue proteomics is increasingly recognized for its role in biomarker discovery and disease mechanism investigation. However, protein solubility remains a significant challenge mass spectrometry (MS)-based tissue proteomics. Conventional surfactants such as sodium dodecyl sulfate (SDS), the preferred surfactant solubilization, are not compatible with MS. Herein, we have screened library of surfactant-like compounds discovered an MS-compatible degradable (MaSDeS) that solubilizes all...
ZnCo<sub>2</sub>O<sub>4</sub>@MnO<sub>2</sub>core–shell nanosheet arrays synthesized<italic>via</italic>a two-step hydrothermal method exhibited an extraordinary electrochemical performance.
Lutein has many physiological functions like antioxidation, anti-cancer, and anti-inflammation, which presents good potential in the development of functional food for eye protection. However, hydrophobicity harsh environment factors during digestive absorption process will greatly reduce lutein bioavailability. In this study, Chlorella pyrenoidosa protein-chitosan complex stabilized Pickering emulsions were prepared, was encapsulated into corn oil droplets to increase its stability...
Abstract Low‐protein (LP) diets are associated with a decreased risk of diabetes in humans, and promote leanness glycaemic control both rodents humans. While the effects an LP diet on mediated by reduced levels branched‐chain amino acids, we have observed that reducing dietary other six essential acids leads to changes body composition. Here, find histidine plays key role response male C57BL/6J mice. Specifically 67% reduces weight gain young, lean mice, adipose mass without altering glucose...
Obesity has become a serious global public health risk threatening millions of people. In this study, the astaxanthin–anthocyanin nanoparticles (AXT-ACN NPs) were used to investigate their effects on lipid accumulation and antioxidative capacity high-sugar-diet-induced high-fat Caenorhabditis elegans (C. elegans). It can be found that lifespan, motility, reproductive C. significantly decreased compared normal nematodes in control group. However, treatment with AXT-ACN NPs resulted prolonged...
ABSTRACT Invasion and metastasis are major causes of mortality in breast cancer (BRCA) patients. LHPP, known for its tumor‐suppressive effects, has an undefined role BRCA. We found reduced LHPP protein BRCA tissues, with lower levels correlating poor patient outcomes. In vitro studies show inhibits cell proliferation, migration, invasion, stemness. vivo xenograft models support LHPP's curbing tumorigenesis lung metastasis. Mechanistically, interacts ERK P38 MAPK, leading to their...
In recent years, ternary transition metal oxides (TTMOs), especially spinel type TTMOs have attracted widespread attention as promising candidates for electrode materials. Among all of the popular TTMOs, MgCo2 O4 is an outstanding one, owing to its superior theoretical capacitance. this work, nanosheet arrays (NSAs) grown directly on nickel foams were fabricated through a facile hydrothermal process at 120 °C 4 h. With series structural and morphological characterization techniques, it was...
Abstract Vanadium‐based metal oxides have attracted widespread attention as a promising candidate for electrode materials owing to the novel morphologies and wide range of practical applications. In this work, microwave‐assisted hydrothermal synthesis method was used first time synthesize CoV 2 O 6 micron blocks Co 3 V 8 nanoparticles. Briefly, heating solution 100 °C adjusting pH can result in desired micro nanoparticles within 10 min. After systematic characterization material structures...
Abstract High‐capacity SiO 2 /C composites with uniform distribution, rice husks (RHs) as raw materials, were scalably prepared by the ball milling method. Based on a fact that porous nanoparticles and carbon in RHs possess natural properties, mill could visibly decrease grain sizes of clustering particles C blocks then improve dispersivity two components, finally forming desirable composite, which can generate more active sites for Li + storage well effectively buffer volume change during...