A5100661295- Immune cells in cancer
- Genetic Mapping and Diversity in Plants and Animals
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Genetic and phenotypic traits in livestock
- Lung Cancer Treatments and Mutations
- Viral Infectious Diseases and Gene Expression in Insects
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Microtubule and mitosis dynamics
- Scoliosis diagnosis and treatment
- Lymphoma Diagnosis and Treatment
- Global Health Care Issues
- Connective tissue disorders research
- Neuroblastoma Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Chronic Disease Management Strategies
- DNA Repair Mechanisms
- Ion channel regulation and function
- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
Shanghai Pulmonary Hospital
2020-2025
Harbin Medical University
2025
Third Affiliated Hospital of Harbin Medical University
2025
Tongji University
2020-2025
Midwestern University
2025
Northwestern University
2025
Capital Medical University
2023-2024
Beijing Sanbo Brain Hospital
2023-2024
Shangrao Normal University
2024
Capital University
2023
Abstract Central and peripheral extensive‐stage small‐cell lung cancer (ES‐SCLC) are reported to be two distinct tumor entities, but their responses the front‐line therapies underlying biological mechanisms remain elusive. In this study, we first compared outcomes of central ES‐SCLC receiving chemotherapy or chemo‐immunotherapy with a cohort 265 patients. Then performed single‐cell RNA sequencing (scRNA‐seq) on nine treatment‐naïve samples investigate potential response differences. Under...
Abstract Emerging evidence has shown that exosomes derived from drug‐resistant tumour cells are able to horizontally transmit phenotype sensitive cells. However, whether shed by EGFR T790M‐mutant–resistant NSCLC could transfer drug resistance not been investigated. We isolated the conditioned medium (CM) of T790M‐mutant cell line H1975 and PC9. The role mechanism in regulating gefitinib was investigated both vitro vivo. Exosome‐derived miRNA expression profiles PC9 were analysed small RNA...
Growing evidence suggests that acquired resistance to targeted therapy in non-small cell lung cancer patients is linked the mutual domestication between tumour and its surrounding microenvironment.Our study aims explore remodelling of microenvironment after osimertinib treatment resistance.We took RNA-seq-based immune infiltration analysis using TIMER 2.0. We carried out flow cytometry assay real-time interaction cells cells. In addition, we analysed exosomes via miRNA-seq label-free...
<h3>Background:</h3> Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity, affecting up to 4% children worldwide. Familial inheritance AIS now recognised and several potential candidate loci have been found. <h3>Methods:</h3> We studied 25 multi-generation families British descent with at least 3 affected members in each family. A genomewide screen was performed using microsatellite markers spanning approximately 10-cM intervals throughout genome. This analysis...
ABSTRACT Invasion and metastasis are major causes of mortality in breast cancer (BRCA) patients. LHPP, known for its tumor‐suppressive effects, has an undefined role BRCA. We found reduced LHPP protein BRCA tissues, with lower levels correlating poor patient outcomes. In vitro studies show inhibits cell proliferation, migration, invasion, stemness. vivo xenograft models support LHPP's curbing tumorigenesis lung metastasis. Mechanistically, interacts ERK P38 MAPK, leading to their...
Abstract Background: Adoptive T-cell therapy has emerged as a promising approach for the treatment of several malignancies, including melanoma. Despite outcomes, therapeutic resistance remains significant challenge, with limited or transient responses observed in many patients. The molecular mechanisms driving pathways have not been thoroughly studied vivo. Systematic characterization genetic regulators adoptive is thus critical designing next-generation synergistic combination therapies and...
Background: The efficacy of programmed cell death 1 (PD-1) or ligand (PD-L1) inhibitors in epidermal growth factor receptor (EGFR)-mutant non-small lung cancer (NSCLC) patients is not satisfactory. Studies have indicated that the ratio CD8+ tumor infiltration lymphocytes (TILs) was associated with immunotherapy efficacy; however, it significantly lower EGFR-mutant than wild type patients. underlying mechanisms need to be studied. Methods: Database analysis, clinical specimens, small RNA...
Abstract Around the world, tuberculosis (TB) remains one of most common causes morbidity and mortality. The molecular mechanism Mycobacterium (Mtb) infection is still unclear. Extracellular vesicles (EVs) play a key role in onset progression many disease states can serve as effective biomarkers or therapeutic targets for identification treatment TB patients. We analysed expression profile to better clarify EVs characteristics explored potential diagnostic markers distinguish from healthy...
Abstract Background Glioma represents the predominant primary malignant brain tumor. For several years, molecular profiling has been instrumental in management and therapeutic stratification of glioma, providing a deeper understanding its biological complexity. Accumulating evidence unveils putative involvement zinc finger proteins (ZNFs) cancer. This study aimed to elucidate role significance ZNF207 glioma. Methods Utilizing online data such as The Cancer Genome Atlas (TCGA), Chinese...
The aim of the study was to investigate incidence, prevalence and characteristics multimorbidity in urban inpatients different age groups. This used data from National Insurance Claim for Epidemiology Research (NICER) calculate overall prevalence, geographic distribution patterns, health care burden, patterns 2017. According our study, 6.68%, 14.87% increases with age. pattern shows that is relatively high South East China. average annual expenditure patients increased rose rapidly,...
Tuberculosis (TB) is the deadliest communicable disease in world with exception of ongoing COVID-19 pandemic. Programmed cell death (PCD) patterns play key roles development and progression many states such that they may offer value as effective biomarkers or therapeutic targets can aid identifying treating TB patients.The Gene Expression Omnibus (GEO) was used to gather TB-related datasets after which immune profiles these data were analyzed examine potential loss homeostasis. Profiling...
The study aims to investigate the effects of (-)-Linarinic acid (LA) and one its derivatives (LAd) on brain injury induced by ischemia. Malonaldehyde (MDA) is determined as an index for lipid peroxidation both in vitro vivo. Mice were pre-treated with LA LAd 3 d. Thereafter, they have incomplete cerebral ischemia bilateral carotid artery occlusion hypotension (BCAOH). In first part vivo experiment, mice divided into four groups: sham (control), ischemia, + (200 mg/kg, i.g.) i.g.). second...
Background The activation of YAP/TAZ transcriptional co-activators, downstream effectors the Hippo/YAP pathway, is commonly observed in human cancers, promoting tumor growth and invasion. aim this study was to use machine learning models molecular map based on pathway explore prognosis, immune microenvironment therapeutic regimen patients with lower grade glioma (LGG). Methods SW1783 SW1088 cell lines were used as vitro for LGG, viability XMU-MP-1 (a small molecule inhibitor Hippo signaling...
2057 Background: Glioma is the most common primary central nervous system malignancy in adults, of which glioblastoma (GBM) accounts for more than 50% incidence and aggressive subtype glioma, with a median survival about 15 months. Oncolytic virus emerges as promising therapy recurrent GBM (rGBM), but its safety efficacy are not evaluated patients rGBM connecting to ventricular system. Methods: This dose-escalating trial study Ad-TD-nsIL12, novel oncolytic adenovirus, The assigned dose...
<title>Abstract</title> Glioblastoma is one of the most fatal malignancies central nervous system, with high mortality and post-treatment recurrence rates. Oncolytic viruses are attractive treatment options for this disease, but must be improved to enhance efficacy safety. Here we describe a phase I, dose-escalating trial study safety Ad-TD-nsIL12, novel oncolytic adenovirus expressing mutant form interleukin-12, in patients recurrent glioblastoma that connects ventricular system. Eight...