A5055444624- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Dietary Effects on Health
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Biochemical effects in animals
- Alzheimer's disease research and treatments
- Regulation of Appetite and Obesity
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Nutrition, Genetics, and Disease
- Sirtuins and Resveratrol in Medicine
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Pancreatic function and diabetes
- Natural Antidiabetic Agents Studies
- Lipid metabolism and biosynthesis
- Nuclear Receptors and Signaling
- Muscle metabolism and nutrition
- Birth, Development, and Health
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Genetic Associations and Epidemiology
William S. Middleton Memorial Veterans Hospital
2018-2024
University of Wisconsin–Madison
2018-2024
University of Aberdeen
2015-2023
Abstract Dietary protein is a critical regulator of metabolic health and aging. Low diets are associated with healthy aging in humans, dietary restriction extends the lifespan healthspan mice. In this study, we examined effect (PR) on development progression Alzheimer’s disease (AD) 3xTg mouse model AD. Here, show that PR promotes leanness glycemic control mice, specifically rescuing glucose intolerance females. induces sex-specific alterations circulating brain metabolites, downregulating...
// Sharon E. Mitchell 1 , Camille Delville Penelope Konstantopedos Jane Hurst 2 Davina Derous Cara Green Luonan Chen 3 Jackie J.D. Han 4 Yingchun Wang 5 Daniel E.L. Promislow 6 David Lusseau Alex Douglas John R. Speakman 1, Institute of Biological and Environmental Sciences, University Aberdeen, UK Mammalian Behaviour & Evolution Group, Integrative Biology, Liverpool, Key laboratory Systems Shanghai Chinese Academy Shanghai, China Laboratory Computational Sciences-Max Planck Partner for...
Sharon E. Mitchell1, Camille Delville1, Penelope Konstantopedos1, Davina Derous1, Cara L. Green1, Luonan Chen2, Jing-Dong J. Han3, Yingchun Wang4, Daniel E.L. Promislow5, Alex Douglas1, David Lusseau1, John R. Speakman1,4 1Institute of Biological and Environmental Sciences, University Aberdeen, Scotland, UK 2Key laboratory Systems Biology, Innovation Center for Cell Signaling Network, Institute Biochemistry Shanghai Chinese Academy Shanghai, China 3Chinese Sciences Key Laboratory...
Calorie restriction (CR) remains the most robust intervention to extend lifespan and improve health span. Using a global mass spectrometry-based metabolomic approach, we identified 193 metabolites that were significantly differentially expressed (SDE) in livers of C57BL/6 mice, fed graded levels CR (10, 20, 30 40% CR) compared mice ad libitum for 12 h day. The differential expression also varied with different feeding groups. Pathway analysis revealed had an impact on carnitine synthesis...
Abstract Low‐protein (LP) diets are associated with a decreased risk of diabetes in humans, and promote leanness glycaemic control both rodents humans. While the effects an LP diet on mediated by reduced levels branched‐chain amino acids, we have observed that reducing dietary other six essential acids leads to changes body composition. Here, find histidine plays key role response male C57BL/6J mice. Specifically 67% reduces weight gain young, lean mice, adipose mass without altering glucose...
// Sharon E. Mitchell 1 , Camille Delville Penelope Konstantopedos Davina Derous Cara L. Green Yingchun Wang 2 Jing-Dong J. Han 3 Daniel E.L. Promislow 4 Alex Douglas Luonan Chen 5 David Lusseau and John R. Speakman 1,2 Institute of Biological Environmental Sciences, University Aberdeen, Scotland, UK State Key Laboratory Molecular Developmental Biology, Genetics Chinese Academy Chaoyang, Beijing, China Computational Sciences-Max Planck Partner for Shanghai Institutes Shanghai, Department...
// Sharon E. Mitchell 1 , ZhanHui Tang Celine Kerbois Camille Delville Davina Derous Cara L. Green Yingchun Wang 2 Jackie J.D. Han 3 Luonan Chen 4 Alex Douglas David Lusseau Daniel E.L. Promislow 5,6 and John R. Speakman 1,2 Institute of Biological Environmental Sciences, University Aberdeen, Scotland, UK State Key Laboratory Molecular Developmental Biology, Genetics Chinese Academy Beijing, China Computational Sciences-Max Planck Partner for Shanghai Institutes Shanghai, Systems Innovation...
Calorie restriction (CR) may extend longevity by modulating the mechanisms involved in aging.Different hypotheses have been proposed for its main mode of action.We quantified hepatic transcripts male C57BL/6 mice exposed to graded levels CR (0% 40% CR) three months, and evaluated responses relative these various hypotheses.Of four signaling pathways implied be linked impact on lifespan (insulin/insulin like growth factor 1 (IGF-1), nuclear factor-kappa beta (NF-ĸB), mechanistic target...
Calorie restriction (CR) remains the most robust intervention to extend life span and improve health span. Using a global mass spectrometry–based metabolomics approach, we identified metabolites that were significantly differentially expressed in plasma of C57BL/6 mice, fed graded levels calorie (10% CR, 20% 30% 40% CR) compared with mice ad libitum for 12 hours day. The differential expression increased severity CR. Pathway analysis revealed CR had an impact on vitamin E B levels, branched...
Abstract Mitochondrial NAD + ‐dependent protein deacetylase Sirtuin3 (SIRT3) has been proposed to mediate calorie restriction (CR)‐dependent metabolic regulation and lifespan extension. Here, we investigated the role of SIRT3 in CR‐mediated longevity, mitochondrial function, aerobic fitness. We report that is required for whole‐body capacity but dispensable CR‐dependent Under CR, loss ( Sirt3 −/− ) yielded a longer overall maximum as compared +/+ mice. This unexpected extension was...
In defiance of the paradigm that calories from all sources are equivalent, we and others have shown dietary protein is a dominant regulator healthy aging. The restriction or branched-chain amino acid isoleucine promotes healthspan extends lifespan when initiated in young adult mice. However, many interventions less efficacious even deleterious aged animals. Here, investigate physiological, metabolic, molecular consequences consuming diet with 67% reduction acids (Low AA), alone Ile), male...
Aging | doi:10.18632/aging.100895. Davina Derous, Sharon E. Mitchell, Cara L. Green, Luonan Chen, Jing‐Dong J. Han, Yingchun Wang, Daniel E.L. Promislow, David Lusseau, John R. Speakman, Alex Douglas