A5018874284- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Neurogenesis and neuroplasticity mechanisms
- Polyamine Metabolism and Applications
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Nerve injury and regeneration
- Pancreatic function and diabetes
- Microfluidic and Capillary Electrophoresis Applications
- HER2/EGFR in Cancer Research
- Click Chemistry and Applications
- Dietary Effects on Health
- Chemical Synthesis and Analysis
- Regulation of Appetite and Obesity
- Genetics, Aging, and Longevity in Model Organisms
- Neuroscience of respiration and sleep
- Estrogen and related hormone effects
- Sulfur Compounds in Biology
University of Denver
2018-2025
San Juan City Hospital
2024
Johns Hopkins University
2015-2024
Johns Hopkins Medicine
2015-2024
Lieber Institute for Brain Development
2012-2021
University Medical Center
2019
Instituto Politécnico Nacional
2019
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2008-2017
National Institute of Neurological Disorders and Stroke
2011-2012
National Institutes of Health
2008-2012
Neuregulin-1 (NRG-1) is genetically linked with schizophrenia, a neurodevelopmental cognitive disorder characterized by imbalances in glutamatergic and dopaminergic function. NRG-1 regulates numerous processes and, the adult, suppresses or reverses long-term potentiation (LTP) at hippocampal synapses. Here we show that stimulates dopamine release hippocampus early-phase LTP via activation of D4 receptors (D4R). fails to depotentiate slices treated antipsychotic clozapine other more selective...
Myogenic tone, an important regulator of vascular resistance, is dependent on smooth muscle (VSM) depolarization, can be modulated by endothelial factors, and increased in several models hypertension. Intermittent hypoxia (IH) elevates blood pressure causes dysfunction. Hydrogen sulfide (H(2)S), a recently described endothelium-derived vasodilator, produced the enzyme cystathionine γ-lyase (CSE) acts hyperpolarizing VSM.Determine whether IH decreases H(2)S production to increase myogenic...
Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder for which there no successful prevention or intervention. The pathological hallmark PD involves the self-assembly of functional Alpha-Synuclein (αS) into non-functional amyloid structures. One potential therapeutic interventions against effective inhibition αS aggregation. However, bottleneck towards achieving this goal identification domains/sequences that are essential Using protein mimetic approach, we have...
Numerous genetic and functional studies implicate variants of Neuregulin-1 (NRG1) its neuronal receptor ErbB4 in schizophrenia many endophenotypes. Although the neurophysiological behavioral phenotypes NRG1 mutant mice have been investigated extensively, practically nothing is known about function NRG2, closest homolog. We found that NRG2 expression adult rodent brain does not overlap with more extensive than originally reported, including striatum medial prefrontal cortex (mPFC), therefore...
ABSTRACT BACKGROUND Individuals with Down Syndrome (DS) frequently develop early onset Alzheimer’s disease (AD) pathological hallmarks closely resembling AD due to several triplicated genes on chromosome 21. Polyamines are small, organic molecules that play a pivotal role for growth and differentiation, dysregulation of polyamine pathways is implicated in pathology. However, their DS-associated unclear. METHODS We analyzed polyamines metabolite levels mouse hippocampal cells human DS-AD...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that the leading cause of dementia, affecting nearly 55 million people across world. One central pathological factors associated with AD aggregation Aβ42, peptide product cleaved through processes in AD. Under conditions, Aβ42 aggregates into insoluble plaques brain and impairs function neurons, which contributes to cognitive decline Therefore, modulation considered potential therapeutic intervention for Using an...
Individuals with Down syndrome (DS) exhibit Alzheimer's disease (AD) pathology at a young age, including amyloid plaques and neurofibrillary tangles (NFTs). Tau can spread via extracellular vesicles, such as exosomes. The cargo of neuron-derived small vesicles (NDEVs) from individuals DS contains p-Tau an early age. goal the study was to investigate whether NDEVs isolated blood in brain wildtype mice. We purified plasma patients DS-AD controls injected quantities using stereotaxic surgery...
Neuregulin-1 (NRG-1) and its receptor ErbB4 are genetically associated with schizophrenia, a complex developmental disorder of high heritability but unknown etiology that has been proposed to result from deficits in functional connectivity synaptic plasticity. Based on pharmacological evidence, imbalances dopaminergic glutamatergic transmission systems believed contribute pathophysiology, genetic data supporting causative role for either sparse. Stimulation NRG-1/ErbB4 signaling inhibits or...
Binge eating palatable foods has been shown to have behavioral and neurochemical similarities drug addiction. GS 455534 is a highly selective reversible aldehyde dehydrogenase 2 inhibitor that reduce alcohol cocaine intake in rats. Given the overlaps between binge abuse, we examined effects of on subsequent dopamine release. Sprague-Dawley rats were maintained sugar (experiment 1) or fat 2) diet. After 25 days, was administered at 7.5 15 mg/kg by an intraperitoneal injection, food monitored....
Obstructive sleep apnea (OSA) is associated with cardiovascular complications including hypertension. Previous findings from our laboratory indicate that exposure to intermittent hypoxia (IH), mimic apnea, increases blood pressure in rats. IH also endothelin-1 (ET-1) constrictor sensitivity a protein kinase C (PKC) <i>δ</i>–dependent manner mesenteric arteries. Because phosphoinositide-dependent kinase-1 (PDK-1) regulates PKC<i>δ</i> activity, we hypothesized PDK-1 contributes the augmented...
The pontine nucleus locus coeruleus (LC) is the primary source of noradrenergic (NE) projections to brain and important for working memory, attention, cognitive flexibility. Individuals with Down syndrome (DS) develop Alzheimer's disease (AD) high penetrance often exhibit memory deficits coupled degeneration LC-NE neurons early in progression AD pathology. Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools that allow targeted manipulation discrete...