A5000672121- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Thermoregulation and physiological responses
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
Institute of Genetics and Developmental Biology
2021-2025
Chinese Academy of Sciences
2021-2025
Beijing Academy of Science and Technology
2025
University of Chinese Academy of Sciences
2021-2025
Abstract Maternal overnutrition during lactation predisposes offspring to develop metabolic diseases and exacerbates the relevant syndromes in males more than females later life. The hypothalamus is a heterogenous brain region that regulates energy balance. Here we combined trait quantification of mother mice under low high fat diet (HFD) feeding lactation, with single nucleus transcriptomic profiling their at peak lacation understand cellular molecular alterations response maternal dietary...
Abstract Gut microbiota deficient mice demonstrate accelerated glucose clearance. However, which tissues are responsible for the upregulated uptake remains unresolved, with different studies suggesting that browning of white adipose tissue, or modulated hepatic gluconeogenesis, may be related to enhanced clearance when gut is absent. Here, we investigate in 22 3 mouse models. We find depletion via treatment antibiotic cocktails (ABX) promotes brown tissue (BAT) and cecum. Nevertheless,...