A5090034675- Gut microbiota and health
- Vitamin C and Antioxidants Research
- Retinoids in leukemia and cellular processes
- Dietary Effects on Health
- Circadian rhythm and melatonin
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Cholesterol and Lipid Metabolism
- Antioxidant Activity and Oxidative Stress
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
The University of Texas Southwestern Medical Center
2019-2024
Circadian rhythmicity is a defining feature of mammalian metabolism that synchronizes metabolic processes to day-night light cycles. Here, we show the intestinal microbiota programs diurnal rhythms in mouse small intestine through histone deacetylase 3 (HDAC3). The induced expression epithelial HDAC3, which was recruited rhythmically chromatin, and produced synchronized oscillations acetylation, gene expression, nutrient uptake. HDAC3 also functioned noncanonically coactivate...
The intestinal microbiota regulates mammalian lipid absorption, metabolism, and storage. We report that the reprograms metabolism in mice by repressing expression of long noncoding RNA (lncRNA) Snhg9 (small nucleolar host gene 9) small epithelial cells. suppressed activity peroxisome proliferator–activated receptor γ (PPARγ)—a central regulator metabolism—by dissociating PPARγ inhibitor sirtuin 1 from cell cycle apoptosis protein 2 (CCAR2). Forced epithelium conventional impaired reduced...
Vitamin A and its derivative retinol are essential for the development of intestinal adaptive immunity. Retinoic acid (RA)–producing myeloid cells central to this process, but how acquire conversion RA is unknown. Here, we show that serum amyloid (SAA) proteins—retinol-binding proteins induced in epithelial by microbiota—deliver cells. We identify low-density lipoprotein (LDL) receptor–related protein 1 (LRP1) as an SAA receptor endocytoses SAA-retinol complexes promotes acquisition...
Autophagy is a key innate immune defense mechanism in intestinal epithelial cells. Bacterial invasion of cells activates antibacterial autophagy through process that requires the adaptor protein MYD88, yet how MYD88 signaling connects to machinery unknown. Here, we show mouse pathogen Salmonella enterica Serovar Typhimurium ( Typhimurium) triggers regulates binding anti-autophagy factor B cell lymphoma 2 (BCL2) essential Beclin1 (BECN1) small enterocytes, lineage. infection activated kinase...