A5021305446- Complement system in diseases
- Immune Cell Function and Interaction
- Inflammation biomarkers and pathways
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
- Dietary Effects on Health
- Hepatitis C virus research
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Mycobacterium research and diagnosis
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
Southwestern University
2024
National Institute of Diabetes and Digestive and Kidney Diseases
2023
National Institutes of Health
2023
The University of Texas Southwestern Medical Center
2022-2023
The intestinal microbiota regulates mammalian lipid absorption, metabolism, and storage. We report that the reprograms metabolism in mice by repressing expression of long noncoding RNA (lncRNA) Snhg9 (small nucleolar host gene 9) small epithelial cells. suppressed activity peroxisome proliferator–activated receptor γ (PPARγ)—a central regulator metabolism—by dissociating PPARγ inhibitor sirtuin 1 from cell cycle apoptosis protein 2 (CCAR2). Forced epithelium conventional impaired reduced...
Peristaltic movement of the intestine propels food down length gastrointestinal tract to promote nutrient absorption. Interactions between intestinal macrophages and enteric nervous system regulate motility, yet we have an incomplete understanding molecular mediators this crosstalk. Here, identify complement component 1q (C1q) as a macrophage product that regulates gut motility. Macrophages were predominant source C1q in mouse most extraintestinal tissues. Although mediates...
ABSTRACT Peristaltic movement of the intestine propels food down length gastrointestinal tract to promote nutrient absorption. Interactions between intestinal macrophages and enteric nervous system regulate motility, yet we have an incomplete understanding molecular mediators this crosstalk. Here identify complement component 1q (C1q) as a macrophage product that regulates gut motility. Macrophages were predominant source C1q in mouse most extraintestinal tissues. Although mediates...
Abstract Background & Aims Direct‐acting antiviral (DAA) therapy has revolutionized treatment for the hepatitis C virus (HCV). While DAA is common, little known about intrahepatic immunological changes after sustained virologic response (SVR). We aim to describe transcriptional alterations of gut microbiome and liver SVR. Methods Twenty‐two HCV patients were evaluated before 9 months 12 weeks sofosbuvir/velpatasvir treatment. All achieved A biopsy, portal blood (direct vein cannulation),...
Abstract Small intestinal epithelial cells (sIECs) form a critical barrier essential for nutrient absorption and host defense. sIECs undergo continuous renewal to maintain their integrity. Phagocytes, such as macrophages, facilitate the clearance of apoptotic that enter subepithelial tissues. However, little is known about how sIEC-phagocyte crosstalk maintains Our study reveals synchrony between sIEC death accumulation specific subset macrophages engaged in engulfing dying cells. Notably,...
Abstract Intestinal Tim4+ CD4+ macrophages are a distinctive macrophage subset that express Tim4, receptor for phosphatidylserine on dying apoptotic cells, Unlike other subsets, they do not depend blood monocytes their turnover, instead self-maintained in the small intestine. The signal(s) responsible self-maintenance and function of is known. We have discovered maintenance gut resident population depends dietary vitamin A its derivative retinoic acid (RA). Retinoic receptors, which direct...