A5101824095- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- MicroRNA in disease regulation
- Saffron Plant Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Ginseng Biological Effects and Applications
- Seaweed-derived Bioactive Compounds
- Polysaccharides and Plant Cell Walls
- Cancer-related Molecular Pathways
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Nanoparticle-Based Drug Delivery
- Circular RNAs in diseases
- Medicinal Plants and Bioactive Compounds
- Biological and pharmacological studies of plants
- Cell Adhesion Molecules Research
- Genomics and Chromatin Dynamics
- Natural product bioactivities and synthesis
- Phytoestrogen effects and research
- Magnetic and Electromagnetic Effects
- Cancer, Lipids, and Metabolism
Beijing University of Chinese Medicine
2014-2024
Southwest Forestry University
2024
Southeast University
2024
Zhejiang Academy of Forestry
2010-2024
Shanghai Jiao Tong University
2019-2021
Soochow University
2020-2021
Second Affiliated Hospital of Soochow University
2021
Renji Hospital
2018-2020
Taixing People's Hospital
2017
Harbin Medical University
2011-2015
Abstract Background Long non-coding RNAs (lncRNAs) have been associated with non-small cell lung cancer (NSCLC), but the underlying molecular mechanisms of their specific roles in mediating aerobic glycolysis poorly explored. Methods Next-generation RNA sequencing assay was performed to identify differentially expressed between NSCLC tissues high 18 F-fluorodeoxyglucose (FDG) uptake and adjacent normal tissues. LINC01123 expression measured by real-time PCR situ hybridization (ISH) assay....
Rationale: Non-small cell lung cancer (NSCLC) is a deadly disease with hallmark of aberrant metabolism. The mechanism glycolysis associated lncRNA underlying the aggressive behaviors NSCLC poorly understood. Methods: expression level AC020978 in was measured by quantitative real-time PCR and fluorescence situ hybridization (FISH) assay. biological role proliferation aerobic determined functional experiments vitro vivo. transcription assessed dual-luciferase reporter chromatin...
Abstract Background Colon cancer is the second leading worldwide. Recurrent disease and chemotherapeutic drug resistance are very common in advanced stage of colon cancer. ATP-citrate lyase (ACLY), first-step rate-controlling enzyme lipid synthesis, elevated However, it remains unclear about exact role ACLY development metastasis. Methods To evaluate metastasis, we performed cell migration invasion assays two ACLY-deficient lines. mouse model used to examine ACLY’s effects on metastasis...
Hypoxia is commonly observed in solid tumors and contributes to the resistance of DNA damage drugs. However, mechanisms behind this are still unclear. In study, we aimed explore effects hypoxia-induced exosomes on non-small cell lung cancer (NSCLC). Methods: NSCLC cells were subjected either normoxic or hypoxic conditions assess survival changes expression levels key proteins. Comparative proteomics performed identify exosomal PKM2 cisplatin-resistant cells-derived exosomes. Functions...
Over 1000 different mutants of the tumor suppressor protein p53 with one amino acid change in core domain have been reported human cancers. In mouse knock-in models, two frequent displayed loss wild-type (wt) function, inhibition wt and p53-independent gain function. The remaining systematically characterized for but not other phenotypes. We report concomitant assessment function interference using URA3-based yeast confirmatory mammalian assays. studied 76 representing 54% over 15 000...
Abstract Traditional Chinese medicine (TCM) is widely used in clinical practice, including skin and gastrointestinal diseases. Here, a potential TCM QY305 (T‐QY305) reported that can modulate the recruitment of neutrophil colon tissue thus reducing cutaneous adverse reaction diarrhea induced by epidermal growth factor receptor inhibitors (EGFRIs). On another hand, T‐QY305 formula, through regulating features would highlight presence N‐QY305, subunit nanostructure contained T‐QY305, confirm...
Abstract Regulating cardiolipin to maintain mitochondrial homeostasis is a promising strategy for addressing Parkinson's disease (PD). Through comprehensive screening and validation process involving multiple models, ginsenoside Rg3 (Rg3) as compound capable of enhancing levels identified. This augmentation in fosters by bolstering unfolded protein response, promoting mitophagy, oxidative phosphorylation. Consequently, this cascade enhances the survival tyrosine hydroxylase positive (TH + )...
The transcription factor and tumor suppressor protein p53 is frequently inactivated in human cancers. In many cases, gene mutations result high levels of inactive, full-length with one amino acid change the core domain that recognizes DNA-binding sites. ability to endow function mutated proteins would dramatically improve cancer therapy, because it reactivate a central apoptotic pathway. By using genetic strategies assays yeast mammalian cells, we identified global motif involving codons...
Accumulative evidence has shown the adverse effects of a geomagnetic field shielded condition, so called hypomagnetic (HMF), on metabolic processes and oxidative stress in animals cells. However, underlying mechanism remains unclear. In this study, we evaluate role HMF regulation cellular reactive oxygen species (ROS) human neuroblastoma SH-SY5Y We found that exposure led to ROS decrease, restoring decrease by additional H2O2 rescued HMF-enhanced cell proliferation. The measurements related...
Host and viral factors influence the HIV-1 infection course. Reduced Nef function has been observed in controllers during chronic phase, but kinetics mechanisms of attenuation such individuals remain unclear. We examined plasma RNA-derived clones from 10 recently infected who subsequently suppressed viremia to less than 2,000 RNA copies/ml within 1 year postinfection (acute controllers) 50 did not control progressors). acute displayed a lesser ability downregulate CD4 HLA class I cell...
Rats intracerebroventricularily (icv) treated with streptozotocin (STZ), shown to generate an insulin resistant brain state, were used as animal model for the sporadic form of Alzheimer's disease (sAD). Previously, we showed in vivo study that 3 months after STZ icv treatment hippocampal adult neurogenesis (AN) is impaired. In present study, examined effects on isolated neural stem cells (NSCs) using vitro approach. We revealed 2.5 mM inhibits proliferation NSCs indicated by reduced number...
The herbal medicine Tong Luo Jiu Nao (TLJN) contains geniposide (GP) and ginsenoside Rg1 at a molar ratio of 10:1. is the major component another medicine, panax notoginseng saponin (PNS). TLJN has been shown to strengthen brain function in humans, animals it improves learning memory. We have previously that reduces amyloidogenic processing Alzheimer's disease (AD) mouse models. Together this suggests may be potential treatment for patients with dementia. Because chronic damage central...
miRNA-489 was shown to be a suppressor factor in many cancers, however, evidence on the effects and mechanism of progression cervical cancer is limited.So we aimed determine function proliferation apoptosis our present study.Interestingly, found that signifi cantly down-regulated tissues.miRNA-489 overexpression inhibited cell improved cells.Further, over-expression suppressed activation PI3K AKT, stimulated P53 proteins expression.In conclusion, results suggested may considered as biomarker...