A5060823509- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Hydrocarbon exploration and reservoir analysis
- Reservoir Engineering and Simulation Methods
- Systemic Lupus Erythematosus Research
- Hydraulic Fracturing and Reservoir Analysis
- Hepatitis B Virus Studies
- Natural product bioactivities and synthesis
- Autophagy in Disease and Therapy
- Food Quality and Safety Studies
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Polysaccharides and Plant Cell Walls
- Sunflower and Safflower Cultivation
- Metabolomics and Mass Spectrometry Studies
- Seismic Imaging and Inversion Techniques
- Traditional Chinese Medicine Studies
- Gastroesophageal reflux and treatments
- Venomous Animal Envenomation and Studies
- CO2 Sequestration and Geologic Interactions
- Saffron Plant Research Studies
- Healthcare and Venom Research
Shandong University of Traditional Chinese Medicine
2009-2024
Beijing City University
2024
Shandong Institute for Product Quality Inspection
2024
Chang Gung Memorial Hospital
2013-2023
China University of Geosciences (Beijing)
2011-2022
Beijing University of Chinese Medicine
2010-2021
Chang Gung University
2020-2021
Chang Gung Children's Hospital
2021
Memorial Hospital of South Bend
2011-2020
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2016
Endothelial damage (ED) has been implicated in accelerating the development of atherosclerosis. The latter condition is a risk factor for developing several cardiovascular diseases (CVDs) associated with high morbidity and mortality rates worldwide.
Abstract DJ ‐1/PARK7, the Parkinson's disease‐related protein, plays an important role in mitochondrial function. However, mechanisms by which ‐1 affects function are not fully understood. Akt is a promoter of neuron survival and partly involved neurodegenerative process. This research aimed at investigating possible relationship between signalling regulating dopaminergic neuron‐like cells SH ‐ SY 5Y PC ‐12. Overexpression was firstly validated both transcriptional translational levels after...
For screening the active phloroglucinols on influenza virus (H5N1) from Dryopteris crassirhizoma NaKai, a database was established including twenty-three that had been isolated crassirhizoma. Their inhibitory effect neuraminidase (NA) of H5N1 screened by molecular docking. As result, three candidates were selected. The rhizomes D. subjected to isolation and purification processes obtain inhibitor candidates. Thirteen obtained, selected two new phloroglucinols. five investigated for their...
The incidence of non-alcoholic fatty liver disease (NAFLD) is significant in hepatitis C virus (HCV) carriers due to multiple mechanisms, and this worsens the progression chronic diseases, such as cirrhosis hepatocellular carcinoma, death. purpose study was examine whether alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio correlates with status hepatosteatosis.A cross-sectional observational study.Community-based annual examination northern Taiwan.A total 1354 participants...
BACKGROUND:Anti-tumor properties of hydroxysafflor-yellow A (HSYA) have been recently revealed, as a series apoptotic factors were confirmed to be regulated by HSYA and associated with peroxisome proliferator-activated receptor Gamma (PPARγ). In this study, we investigated the cell apoptosis mechanism via activated PPARγ signal in human gastric carcinoma cells. MATERIAL AND METHODS:BGC-823 cells cultured divided into 5 independent groups: Tumor, HSYA, HSYA+PPARγ inhibitor (GW9662), PPARg...
Abstract The evolution of ferritin levels in hepatitis C virus (HCV)-infected patients with sustained virological responses (SVRs) following various therapy regimens remains elusive. An 8-year prospective cohort study 1194 HCV-infected [interferon-based (n = 620), direct-acting antiviral agent (DAA) 355)] was conducted. At baseline, sex, alanine aminotransferase (ALT), triglycerides, homeostatic model assessment insulin resistance (HOMA-IR), estimated glomerular filtration rate (eGFR),...
The impact of sex on metabolic alterations in individuals with hepatitis B virus (HBV) or C (HCV) infection remains elusive. A community-based study was performed to assess sex, age, body mass index, the lipid profile, blood pressure, glucose, alanine aminotransferase, HBV surface antigen (HBsAg), and HCV antibody levels, smoking alcohol drinking habits, cardiometabolic diseases, including diabetes, hypertension, cardiovascular events, renal diseases. HCV-RNA level genotype were further...
The real-world benefits of direct-acting antiviral (DAA)-induced sustained virologic response (SVR) on the de novo occurrence and progression esophageal varices (EV) remain unclear in patients with hepatitis C virus (HCV)-related liver cirrhosis (LC). This is a retrospective cohort study evaluating all Child-Pugh class A HCV-related LC during 2013 to 2020 Chang Gung Medical System. total 215 fit inclusion criteria were enrolled. Of them, 132 (61.4%) achieved DAA induced-SVR 83 (38.6%) did...
Xiaoyaosan (XYS) decoction is a famous prescription for the treatment of mental disorders in China. In this experiment, we explored way which XYS decoction-reverse hippocampus neuron apoptosis vitro. We used decoction-containing serum to treat oxidative-stress-induced and immunofluorescence determine concentration free calcium, mitochondrial membrane potential, apoptotic rate neuron. Results showed that 3-hour oxidative stress decrease increase calcium via triggering pathological changes...
Context It has been found that hydroxysafflor-yellow A (HSYA) inhibits angiogenesis and the proliferation of abnormal human umbilical vein endothelial cells (HUVECs) in our previous study; however, mechanism is still unclear.Objective This study investigates mechanisms HSYA inhibiting HUVECs through detecting expression vascular growth factor (VEGF) its receptor (KDR), protein Ras-Raf-MEK-ERK-signalling pathway.Materials methods HepG2 cell cultural supernatant was used to culture make...
Da-Bu-Yin-Wan (DBYW) and Qian-Zheng-San (QZS), two classic traditional Chinese medicinal formulas, were clinically employed to treat Parkinson's disease (PD). Our previous studies demonstrated neuroprotective effects of them on mitochondrial function in PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The purpose this research was investigate their possible mechanisms the light ATP-sensitive potassium (mitoKATP) channels. effect DBYW QZS dopamine (DA) neurons...
To investigate the effect of Da-Bu-Yin-Wan and Qian-Zheng-San (DBYW QZS) on mitochondrial mass in Parkinson's disease (PD) cell model induced by 1-Methyl-4-phenylpyridinium Ion (MPP+). The SH-SY5Y was selected treated with MPP+. PD intervened DBYW QZS. CCK-8 method used to detect survival rate cells each group. Mitochondria labeled mitoTracker®Red CMXRos probe observed laser scanning confocal microscope, ImageJ software process images measure form factors; Tetramethylrhodamine methyl ester...
Although the rhizomes of Rheum nobile Hook. f. et Thoms (Polygonaceae) are widely used in Tibetan medicine, no previous investigations regarding biological activities and rarely chemical constituents this plant have been reported. As part an ongoing search for novel bioactive agents, a phytochemical investigation R. led to isolation two new compounds Rheumone B (1) piceatannol-4'-O-β-D-(6″-O-acetyl)-glucoside (2), together with 15 known by gel filtration over Sephadex LH-20 preparative HPLC....