A5101978755- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Nutrition and Health in Aging
- Endometrial and Cervical Cancer Treatments
- COVID-19 Clinical Research Studies
- Reproductive Biology and Fertility
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Colorectal and Anal Carcinomas
- Ectopic Pregnancy Diagnosis and Management
- Diet and metabolism studies
- Ovarian function and disorders
- Lung Cancer Treatments and Mutations
- Signaling Pathways in Disease
- Pancreatic and Hepatic Oncology Research
- Pharmacological Effects of Natural Compounds
- Endometriosis Research and Treatment
- Gestational Trophoblastic Disease Studies
- Cancer Risks and Factors
- Nuclear Receptors and Signaling
- COVID-19 and Mental Health
Tongji Hospital
2019-2024
Huazhong University of Science and Technology
2014-2024
Xuchang University
2022-2024
Chinese PLA General Hospital
2020-2024
National Clinical Research Center for Digestive Diseases
2020-2024
Ministry of Education of the People's Republic of China
2024
Ocean University of China
2023
First Hospital of Jilin University
2019-2022
Changzhou University
2022
Yantaishan Hospital
2022
Abstract Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed facilities have endeavored to mitigate pandemic, but mortality COVID-19 continues increase. Here, we present a risk prediction model for (MRPMC) that uses patients’ clinical data on admission stratify patients by risk, which enables physiological deterioration and death up 20 days in advance. This ensemble is built using four machine learning methods including Logistic Regression,...
Objective: This study was intended to investigate the relationship between COVID-19 disease and ovarian function in reproductive-aged women. Methods: Female patients of reproductive age were recruited January 28 March 8, 2020 from Tongji Hospital Wuhan. Their baseline clinical characteristics, as well menstrual conditions, recorded. Differentials reserve markers sex hormones (including anti-Müllerian hormone [AMH], follicle-stimulating [FSH], ratio FSH luteinizing [LH], estradiol [E2],...
Recent studies have indicated that females with coronavirus disease 2019 (COVID-19) a lower morbidity, severe case rate, and mortality better outcome than those of male individuals. However, the reasons remained to be addressed.
The ferocious global assault of COVID-19 continues. Critically ill patients witnessed significantly higher mortality than severe and moderate ones. Herein, we aim to comprehensively delineate clinical features explore risk factors developing critical disease.This is a Mini-national multicenter, retrospective, cohort study involving 2,387 consecutive inpatients that underwent discharge or death between January 27 March 21, 2020. After quality control, 2,044 were enrolled. Electronic medical...
Summary Background As of March 2, 2020, SARS-CoV-2 has infected more than 80174 people and caused 2915 deaths in China. This virus rapidly spreads to 56 countries worldwide. Thus, order effectively block its transmission, it is urgent uncover all the possible transmission routes SARS-CoV-2. Methods From January 28 February 18, 35 female patients diagnosed with COVID-19 Tongji Hospital were included this descriptive study. The gynecologic history, clinical characteristics, laboratory findings...
// Chunyou Wang 1, * , Pian Liu 2, Heshui Wu 1 Pengfei Cui Yongfeng Li Yao 3 Zhiqiang Shanmiao Gou Pancreatic Disease Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic China 2 Cancer Center, Department Hepatobiliary Surgery, These authors have contributed equally to this work Correspondence to: Gou, e-mail: gousm@163.com Keywords: miR-323-3p, pancreatic ductal adenocarcinoma, SMAD2, SMAD3 Received: August 14,...
Abstract Importance How to explain the better prognosis of female coronavirus disease 2019 (COVID-19) patients than that males? Objective To determine correlation between menstruation status/sex hormones and COVID-19, identify potential protective factors for patients. Design, Setting, Participants A cross-sectional study COVID-19 who were hospitalized at Tongji Mobile Cabin Hospitals from Jan 28, 2020 March 8, 2020. Exposures Confirmed SARS-CoV-2 infection. Main Outcomes Measures Sex...
Abstract Background Evidence for the efficacy of immunotherapy in biliary tract cancer (BTC) is limited and unsatisfactory. Methods Chinese BTC patients receiving a PD-1 inhibitor with chemotherapy, monotherapy or chemotherapy alone were retrospectively analyzed. The primary outcome was overall survival (OS). key secondary outcomes progression-free (PFS) safety. Patients previously treated any agent targeting T cell costimulation immune checkpoints excluded. Results study included 77 (a plus...
Tissue repair/wound healing, in which angiogenesis plays an important role, is a critical step many diseases including chronic wound, myocardial infarction, stroke, cancer, and inflammation. Recently, we were the first to report that orphan nuclear receptor TR3/Nur77 mediator of its associated microvessel permeability. Tumor growth induced by VEGF-A, histamine, serotonin are almost completely inhibited Nur77 knockout mice. However, it not known whether any roles wound healing. In these...
Cancer cachexia (CC) is a devastating metabolic syndrome characterized by skeletal muscle wasting and body weight loss, posing significant burden on the health survival of cancer patients. Despite ongoing efforts, effective treatments for CC are still lacking. Metabolomics, an advanced omics technique, offers comprehensive analysis small-molecule metabolites involved in cellular metabolism. In research, metabolomics has emerged as valuable tool identifying diagnostic biomarkers, unravelling...
The concept of neurotrophic factor tyrosine kinase receptor (NTRK) fusion tumor has emerged in recent years. Moreover, NTRK is unusual common tumors but can often be identified rare tumors. cervical or uterine are mainly recognized through case reports due to their extremely low incidence. In this study, we reported a new EML4-NTRK3 sarcoma enhance its recognition. To the best our knowledge, first from Chinese institution. We also conducted literature review, which total 19 cases and 4 were...
Cachexia is a complex metabolic disorder and muscle atrophy syndrome, impacting 80% patients with advanced cancers. Malignant glioma considered to be one of the deadliest human cancers, accounting for about 60% all primary brain tumors. However, cachexia symptoms induced by have received little attention. This work aims explore skeletal in orthotopic murine models. BALB/c nude mice were orthotopicly implanted normal glial (HEB) (WHO II CHG5 WHO IV U87) cells. depicted phenotypic,...
BACKGROUNDDistant metastasis, particularly visceral metastasis (VM), represents an important negative prognostic factor for prostate cancer (PCa) patients.However, due to the lower rate of occurrence VM, studies on these patients are relatively rare.Consequently, focusing factors associated with PCa VM highly desirable. AIMTo investigate overall survival (OS) in lung, brain, and liver metastases, respectively, evaluate impact site-specific number-specific OS. METHODSData were extracted from...
Apolipoprotein A-I (apoA-I) mimetic peptide, D-4F, exhibits anti-atherogenic effects similar to high-density lipoprotein (HDL). However, it remains elusive whether D-4F and HDL share molecular mechanisms underlying endothelial cell protections. We here compared the metabolic changes in cells induced by against oxidized low-density (ox-LDL), which may be of benefit understanding protective D-4F. Functional assays including wound healing, transwell migration tube formation were used evaluate...
Cachexia is a complex metabolic derangement syndrome that affects approximately 50-80% of cancer patients. So far, few works have been reported to provide global overview gastric cachexia (GCC)-related changes. We established GCC murine model by orthotopicly implanting BGC823 cell line and conducted NMR-based metabolomic analysis tissues, sera, gastrocnemius. The with typical symptoms, confirmed significant weight loss muscle atrophy, showed distinctly distinguished profiles tumors,...
Abstract Previous studies have shown that miRNAs involved in a number of biological processes, such as cell growth, development, differentiation, and apoptosis. The dysregulation miRNA expression is associated with various diseases, including cervical cancer. However, the involvement miR‐3647‐5p progression tumors unclear. In this study, we confirmed was down‐regulated during carcinogenesis which positively correlated prognosis patients addition, our study showed can inhibit proliferation...
Premature ovarian insufficiency (POI) may lead to early menopause, fertility loss and birth defects without effective treatment. Here, we explored the efficacy safety of gene therapy rescue function in both natural aging doxorubicin (Dox) induced POI mice. Sirt1 Tgfbr2 were screened out identified as key genes murine human tissues. Then, adenovirus (AdV) was selected a suited carrier for infection after comparison multiple viral vectors. In two models, significantly improved AdV-Sirt1...
The purpose of this study was to assess the comparative efficacy six programmed cell death-1 inhibitors (nivolumab, pembrolizumab, sintilimab, tislelizumab, toripalimab, and camrelizumab) that have been used as first-line therapy for Chinese patients with advanced non-small lung cancer (NSCLC), which remains unclear. We determined differences in by observing patient survival data, goal informing future treatment options. Retrospective data analysis from June 2015 April 2023 included 913...
Cesarean scar pregnancy (CSP) can have catastrophic consequences, but a standardized diagnosis and treatment for CSP are lacking. At least 10 different treatments currently available, further confusing selection. The aim of this study was to compare the outcomes using laparotomy or laparoscopy treat CSP.We reviewed data from 935 patients with suspected 1 January 2013 31 December 2018. A total 278 were included in study, whom 121 treated 157 laparotomy. We compared analyzed characteristics...