A5058600360- Neuroscience and Neuropharmacology Research
- Toxic Organic Pollutants Impact
- Corneal surgery and disorders
- Cancer-related molecular mechanisms research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Intraocular Surgery and Lenses
- CRISPR and Genetic Engineering
- Per- and polyfluoroalkyl substances research
- Stress Responses and Cortisol
- Pregnancy and preeclampsia studies
- Gut microbiota and health
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Effects and risks of endocrine disrupting chemicals
- RNA Research and Splicing
- Prenatal Screening and Diagnostics
- RNA modifications and cancer
- Environmental Quality and Pollution
- Preterm Birth and Chorioamnionitis
- Blood donation and transfusion practices
- Intracerebral and Subarachnoid Hemorrhage Research
- Birth, Development, and Health
Nanjing Medical University
2003-2025
Nanjing Brain Hospital
2025
Nankai University
2022-2024
Central South University
2024
Xiangya Hospital Central South University
2024
Ministry of Industry and Information Technology
2024
Chongqing University of Technology
2024
First Affiliated Hospital of Guangzhou Medical University
2023
Guangzhou Medical University
2023
State Key Laboratory of Respiratory Disease
2023
The ferocious global assault of COVID-19 continues. Critically ill patients witnessed significantly higher mortality than severe and moderate ones. Herein, we aim to comprehensively delineate clinical features explore risk factors developing critical disease.This is a Mini-national multicenter, retrospective, cohort study involving 2,387 consecutive inpatients that underwent discharge or death between January 27 March 21, 2020. After quality control, 2,044 were enrolled. Electronic medical...
Significance The major spliceosome is required for mRNA processing and believed to be essential cell survival. Here we report that mutations affecting the are associated with nonobstructive azoospermia (NOA), a common but poorly understood cause of male infertility in humans. Specifically, dysregulation impairs differentiation spermatogonia, abolishing maturation germ cells into sperm. requirement during spermatogonial highly conserved among species. Our study has uncovered genetic causes...
Non-homologous end-joining (NHEJ) and homologous recombination repair (HRR), contribute to ionizing radiation (IR)-induced DNA double-strand breaks (DSBs). Mre11 binding is the first step for activating HRR Ku initiating NHEJ. High-linear energy transfer (LET) IR (such as high charged particles) killing more cells at same dose compared with low-LET X or γ rays) due inefficient However, these phenomena have not been demonstrated animal level mechanism by which high-LET does affect efficiency...
Health literacy (HL) has become an important public health issue and is receiving growing attention. However, the HL levels of military college students in China have never been analyzed. This study aimed to investigate related associate factors Chongqing, China. Data was obtained with "Chinese Citizen Literacy Questionnaire (2012 edition)" from 3183 aged 16-28 years at Chongqing December 2015. A total score ≥80 points determined adequate HL, level defined as proportion who had out number...
Abstract Chemotherapeutic agents, including cisplatin, have remained a cornerstone of lung adenocarcinoma (LUAD) treatment and continue to play an essential role in clinical practice, despite remarkable progress therapeutic strategies. Hence, thorough comprehension the molecular mechanisms underlying chemotherapeutic agent resistance is paramount. Our investigation centered on potential involvement NPAS2 gene LUAD, which highly expressed tumors its high expression has been associated with...
Purpose . To evaluate the role of corneal epithelium in riboflavin/ultraviolet-A (UVA) mediated collagen cross-linking treatment. Methods Fifty New Zealand rabbits were divided into 5 groups: UVA treatment with or without epithelium, UVA+riboflavin and control any All sacrificed after irradiation subsequently 4 mm × 10 strips harvested for biomechanical evaluation. Results alone did not enhance maximal stress Young’s modulus specimens (3.15 ± 0.56 mpa, 1.00 0.09 mpa) (3.53 0.85 0.94 0.21...
AbstractThe implicit association test (IAT) is a promising method used to assess individual attitudes by indirectly measuring the strengths of associations between target and attribute categories. To date, cognitive processes involved in prosocial attitude IAT task have received little attention. The present study examined temporal dynamics that measures using event-related potentials (ERPs). ERP results revealed enhanced N2 amplitudes for incongruent trials when compared with congruent P300...
Loss-of-function mutation of Akt3 in humans has been associated with microcephaly and cognitive defects. Two Akt isoforms, Akt1 Akt3, are highly expressed hippocampal pyramidal cells. We explored the roles respectively, spatial cognition underlying mechanisms.We used knockout (Akt1-KO) (Akt3-KO) mice to examine influence deficiency on memory, as well induction maintenance CA1 NMDA receptor-dependent protein synthesis-dependent long-term potentiation (LTP).Long-term memory was impaired...
Williams-Beuren syndrome (WBS) is a microdeletion disorder with cognitive phenotype. NSUN5 gene, which encodes cytosine-5 RNA methyltransferase, located in WBS deletion locus. To investigate the influence of on behaviors, we produced single-gene Nsun5 knockout (Nsun5-KO) mice. Here, report that adult Nsun5-KO mice showed spatial deficits. Size brain and hippocampal structures number CA1 or CA3 pyramidal cells did not differ from WT Basal properties Schaffer collateral-CA1 synaptic...
Abstract Participants in deep space missions face protracted exposure to galactic cosmic radiation (GCR). In this setting, lung cancer is a significant component of the overall risk radiation-exposure induced death. Here we investigate persistent effects GCR on DNA repair capacity lung-derived epithelial cells, using an enzyme-stimulated chromosomal rearrangement as endpoint. Replicate cell cultures were irradiated with energetic 48 Ti ions (a component) or reference γ-rays. After six-day...
Akt signaling has been associated with adult neurogenesis in the hippocampal dentate gyrus (DG). We reported cognitive dysfunction Akt3 knockout (Akt3-KO) mice down-regulation of mTOR activation. However, little is known about effects on neurogenesis. Herein, we show that progenitor cells, neuroblasts, and mature newborn neurons DG expressed protein. The phosphorylation was increased after voluntary wheel running for 7 days wild-type (running WT mice), but not Akt3-KO mice). Subsequently,...
A rapid, accurate, non-sputum-based triage test for diagnosing tuberculosis (TB) is a high-priority need. Cepheid developed novel prototype blood test, Xpert