A5054686355- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Gut microbiota and health
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Advanced X-ray and CT Imaging
- Cutaneous Melanoma Detection and Management
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Pancreatic and Hepatic Oncology Research
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Mycobacterium research and diagnosis
- Cancer Mechanisms and Therapy
- CAR-T cell therapy research
- Metabolomics and Mass Spectrometry Studies
- Cytokine Signaling Pathways and Interactions
- Cancer Treatment and Pharmacology
- Prostate Cancer Treatment and Research
- Cancer-related Molecular Pathways
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
The Ohio State University
2019-2025
The Ohio State University Wexner Medical Center
2020-2025
Linyi People's Hospital
2014-2025
Shanxi Medical University
2023-2025
Institute of Physics
2001-2024
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2020-2024
Tongji Hospital
2020-2023
Huazhong University of Science and Technology
2020-2023
Hunan University
2021-2022
Chinese Academy of Agricultural Sciences
2021
Abstract Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed facilities have endeavored to mitigate pandemic, but mortality COVID-19 continues increase. Here, we present a risk prediction model for (MRPMC) that uses patients’ clinical data on admission stratify patients by risk, which enables physiological deterioration and death up 20 days in advance. This ensemble is built using four machine learning methods including Logistic Regression,...
The basic helix-loop-helix transcription factor achaete-scute complex homologue 1 (ASCL1) is essential for the development of normal lung neuroendocrine cells as well other endocrine and neural tissues. Small cell cancer (SCLC) non-SCLC with features express ASCL1, where may play a role in virulence primitive phenotype these tumors. In this study, RNA interference knockdown ASCL1 cultured SCLC resulted inhibition soft agar clonogenic capacity induction apoptosis. cDNA microarray analyses...
The ferocious global assault of COVID-19 continues. Critically ill patients witnessed significantly higher mortality than severe and moderate ones. Herein, we aim to comprehensively delineate clinical features explore risk factors developing critical disease.This is a Mini-national multicenter, retrospective, cohort study involving 2,387 consecutive inpatients that underwent discharge or death between January 27 March 21, 2020. After quality control, 2,044 were enrolled. Electronic medical...
4000 Background: E/GEJ adenocarcinoma has a high mortality rate despite curative intent therapy. Although the use of immune checkpoint inhibition (ICI) in combination with chemotherapy metastatic setting and as adjuvant monotherapy both confer survival benefits, its role neoadjuvant chemoradiation or other ICIs remains unclear. Here we report impact nivo on pCR pts receiving part EA2174 clinical trial. Methods: Pts localized T1N1-3M0 T2-3N0-2M0 an ECOG PS 0-1 deemed surgical candidates for...
In thyroid cancer clinical trials, agents targeting VEGF receptors (VEGFR) and RET, among other kinases, have led to partial responses but few complete or durable responses. The RAF-MEK-ERK PI3K-AKT-mTOR signaling pathways are frequently activated in differentiated medullary (DTC MTC) may provide therapeutic targets for these diseases. We tested a novel drug combination RAF, phosphoinositide 3-kinase (PI3K), mTOR, plus VEGFR2 preclinical models with defined genetic backgrounds.RAF265, an...
Abstract Taxanes remain one of the most effective medical treatments for breast cancer. Clinical trials have coupled taxanes with immune checkpoint inhibitors in patients triple-negative cancer (TNBC) promising results. However, mechanism linking to activation is unclear. To determine if paclitaxel could elicit an antitumoral response, we sampled tumor tissues from TNBC receiving weekly (80 mg/m2) and found increased stromal tumor-infiltrating lymphocytes micronucleation over baseline three...
The spread of COVID-19 has led students to take classes online (rather than face-to-face) worldwide, including in China. For this study, we conducted qualitative focus group discussions identify the experience and difficulties faced by physical education higher taking classes, impact on their activity performance, as well some health problems they face while during quarantine period, such weight gain, depression, anxiety. Finally, utilizing Mayer’s learning model a conceptual framework,...
Importance Nonclinical studies suggest that the combination of poly(ADP-ribose) polymerase and programmed cell death 1/programmed death–ligand 1 inhibitors has enhanced antitumor activity; however, patient populations may benefit from this have not been identified. Objective To evaluate whether avelumab talazoparib is effective in patients with pathogenic BRCA1/2 or ATM alterations, regardless tumor type. Design, Setting, Participants In pan-cancer tumor-agnostic phase 2b nonrandomized...
Context: Gastrointestinal (GI) carcinoid tumors elaborate serotonin and other vasoactive substances, causing the syndrome. Based on developmental biology data, we hypothesized that basic helix-loop-helix transcription factors, including achaete-scute complex homolog-like 1 (Ascl1)/hASH1, Notch signaling pathway might regulate neuroendocrine phenotype in GI carcinoids. Objective: The aim of this study was to evaluate expression factors components carcinoids model their interaction a relevant...
Context: Activating mutations in the BRAF gene, primarily at V600E, are associated with poorer outcomes patients papillary thyroid cancer. MAPK kinase (MEK), immediately downstream of BRAF, is a promising target for ras-raf-MEK-ERK pathway inhibition.
Context: Differentiated thyroid cancer and anaplastic tumors frequently have activation of the ras/raf /MAPK kinase (MEK)/ERK phosphatidylinositol 3-kinase (PI-3K)/AKT/mammalian target rapamycin (mTOR) signaling pathways. Objective: The objective study was to investigate efficacy MEK mTOR inhibitors in preclinical treatment models with defined mutation status. Experimental Design: inhibitor AZD6244 (ARRY-142886) were tested separately combination 10 differentiated cell lines a xenograft...
Abstract Tumor‐associated macrophages (TAMs) play critical roles in reprogramming other immune cells and orchestrating antitumor immunity. However, the interplay between TAMs tumor responsible for enhancing evasion remains insufficiently understood. Here, we revealed that interleukin (IL)‐1β was among most abundant cytokines within vitro tumor‐macrophage coculture system, enhanced IL‐1β expression associated with impaired cytotoxicity of CD8 + T human ovarian cancer, indicating possibility...
Abstract Tumor hypoxia has been shown to predict poor patient outcomes in several cancer types, partially because it reduces radiation’s ability kill cells. We hypothesized that some of the clinical effects could also be due its impact on tumor microbiome. Therefore, we examined RNA sequencing data from Oncology Research Information Exchange Network database patients with colorectal treated radiotherapy. identified microbial RNAs for each and related them hypoxic gene expression scores...
Emerging evidence supports the important role of tumor microbiome in oncogenesis, cancer immune phenotype, progression, and treatment outcomes many malignancies. In this study, we investigated metastatic melanoma its potential roles association with clinical outcomes, such as survival, patients disease treated checkpoint inhibitors (ICI). Baseline samples were collected from 71 before ICIs. Bulk RNA sequencing (RNA-seq) was conducted on formalin-fixed, paraffin-embedded fresh frozen samples....
Abstract Lessons Learned Pancreatic neuroendocrine tumors versus carcinoid should be examined separately in clinical trials. Progression-free survival is more clinically relevant as the primary endpoint (rather than response rate) phase II trials for low-grade tumors. Background. The most common subtypes of (NETs) are pancreatic islet cell and carcinoids, which represent only 2% all gastrointestinal malignancies. Histone deacetylase (HDAC) inhibitors have already been shown to suppress tumor...
Abstract Evidence supports significant interactions among microbes, immune cells, and tumor cells in at least 10%–20% of human cancers, emphasizing the importance further investigating these complex relationships. However, implications significance tumor-related microbes remain largely unknown. Studies have demonstrated critical roles host cancer prevention treatment responses. Understanding between can drive diagnosis microbial therapeutics (bugs as drugs). Computational identification...
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