A5014889450- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Seismic Imaging and Inversion Techniques
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Seismic Waves and Analysis
- Geophysical Methods and Applications
- Hydraulic Fracturing and Reservoir Analysis
- Drilling and Well Engineering
- Ubiquitin and proteasome pathways
- High-pressure geophysics and materials
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- earthquake and tectonic studies
- Seismology and Earthquake Studies
- Geological and Geochemical Analysis
- Virus-based gene therapy research
- Viral Infections and Vectors
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Drug-Induced Hepatotoxicity and Protection
- Phagocytosis and Immune Regulation
- Climate Change and Health Impacts
- Acute Lymphoblastic Leukemia research
- Protein Degradation and Inhibitors
The Ohio State University Wexner Medical Center
2023-2025
The Ohio State University
2020-2024
Grantmakers for Effective Organizations
2005-2024
Guangxi Research Institute of Chemical Industry
2022
Union Hospital
2022
Huazhong University of Science and Technology
2022
Cooperative Institute for Research in Environmental Sciences
1991-1995
University of Colorado Boulder
1995
Beijing Seismological Bureau
1988
Peking University
1985
The stress tensor orientation was estimated based on inversion from 238 first motion fault plane solutions of earthquakes with mostly M = 3.5 ± 0.6 located in the 10‐km radius Kaoiki crustal volume. Separate inversions for subvolumes containing 20–50 events yielded same results several adjacent volumes, suggesting that is homogeneous those parts area and are stable meaningful. Five spatial subsets data were found which at least one principal axes different other sets by 20°–80° confidence...
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<div>Abstract<p>Colorectal cancer is the second leading cause of mortality in United States. Although immune checkpoint blockade therapies including anti-PD-1/PD-L1 have been successful treating a subset patients with colorectal cancer, response rates remain low. We found that riluzole, well-tolerated FDA-approved oral medicine for amyotrophic lateral sclerosis, increased intratumoral CD8<sup>+</sup> T cells and suppressed tumor growth colon syngeneic immune–competent...
Abstract BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in US. 5-fluorouracil (5-FU)-based chemotherapies combination with targeted agents remain standard care patients metastatic or locally advanced disease. New treatment strategies are needed for CRC microsatellite stable Preclinical studies showed that riluzole, an oral medicine amyotrophic lateral sclerosis, inhibits glutamate release and synergizes 5-FU to reduce cell viability lines....
FOLFOX, composed of 5-FU, oxaliplatin and leucovorin, is a first line chemotherapy regimen for colorectal cancer (CRC) treatment. In this study, we show that 5-FU induce DNA damage activate cGAS/STING signaling leading to enhanced expression interferon (IFN) β, IFN-stimulated genes inflammatory cytokines in mouse human colon cells as well increased intratumoral CD8 + T mice. Crucially, increase PD-L1 at the mRNA protein levels, which has been shown inhibit cell function. Depletion cGAS,...
Abstract The cGAS/STING cytosolic DNA-sensing pathway plays a significant role in antitumor immunity. Expression of STING is tightly regulated and commonly reduced or defective many types cancer. We have identified SIX4 as regulator expression colon cancer cells. showed that knockout decreased at the mRNA protein levels while ectopic increased expression. Depletion led to attenuated activation downstream signaling. Reexpression cells reversed effect. Ectopic enhanced DMXAA cGAMP-induced...
The 95 best-quality fault-plane solutions for earthquakes in a 30 by 10 km area near the epicenter of 1868 Hawaiian earthquake ( M about 7.9) were used estimating orientation stress and strain tensors. Most had magnitudes ML = 3.5 ± 0.6 with nine events range 4.2 ≦ 5.5. Although this area, Hilea, is capable great earthquakes, it seldom produces 5.5 6.5. We found that directions slip principal strains are much more uniform Hilea than neighboring regions Kaoiki south Kona, not varying 15°....
To analyze the changes of coagulation function in severe fever with thrombocytopenia syndrome (SFTS) and its relationship thrombocytopenia, to explore value as an early predictor severity SFTS. The clinical data 428 SFTS patients (70 deaths 358 survivors) admitted Department Infectious Disease at Wuhan Union Hospital from January 2014 July 2020 were retrospectively analyzed. differences parameters disseminated intravascular (DIC) scores between two groups compared. results showed that...
We applied microfracture vector scanning (VS, i.e., migration of 3D vector) for microseismic monitoring 2 wells, using direct transverse wave and on surface, the fracturing layers vertical depths 6550m 6691m 11/9/2023 4/16/2024, respectively. The detection purpose is to evaluate effect, study feasibility applying VS surface monitor ultra-deep fracturing. tried our best meet necessary conditions, improve signal-to-noise ratio (S/N), in data acquisition, denoising, migration, reasonable...
101 Background: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in US. 5-fluorouracil (5-FU) based chemotherapies combination with targeted agents remain standard care patients metastatic or locally advanced disease. It essential to develop new treatment strategies CRC microsatellite stable disease, whom immune checkpoint blockade ineffective. Our preclinical studies showed riluzole, an oral medicine for amyotrophic lateral sclerosis, can increase intratumoral...
Abstract Colorectal cancer is the second leading cause of mortality in United States. Although immune checkpoint blockade therapies including anti-PD-1/PD-L1 have been successful treating a subset patients with colorectal cancer, response rates remain low. We found that riluzole, well-tolerated FDA-approved oral medicine for amyotrophic lateral sclerosis, increased intratumoral CD8+ T cells and suppressed tumor growth colon syngeneic immune–competent mice. Riluzole-mediated suppression was...
To satisfy the necessary condition of applying vector scanning, which is that all records have to be random with small amplitudes, we avoid, identify, and suppress any visible or hidden regular interferes in background records. Except for data acquisition, another important segment processing. Our processing progress covers jobs: (1) preparation, including a scanning geometric design, making 3D velocity model, calculating corresponding travel time table between each pair station point whole...
Objective: To retrospectively analyze the characteristics and influencing factors of liver function changes in 111 elderly patients with COVID-19 pneumonia. Methods: admitted to Department Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University Science Technology from February 5 March 3, 2020 were enrolled. According severity disease condition, they divided into severe group (n=40), normal (n=71), abnormal (n=86) (n=25). The indexes related [total bilirubin (TBil),...
With the rapid development of computer technology and Internet era, machine vision is a new science formed by cross-integration various disciplines such as image processing theory, advanced information digital signal methods based on computers. The application in has become an inevitable trend, it can better acquire understand images, quickly effectively analyze, extract useful targets provide decision makers with required content. This also improve work efficiency accuracy to achieve more...
We estimated stress and seismic strain tensors for the Kilauea volcano's south flank. The orientation inversion calculation were performed using fault-plane solutions. principal directions are approximately uniformly distributed in space time during interval covered by data. However, σ1, σ3 plane is orthogonal to є1, є3 plane. Therefore, a weak layer may exist beneath σ1 has plunge of 59° an azimuth 152°, with 10° 95 per cent confidence range. also developed magnitude estimate magnitudes...
This paper presents results of processing landmine and UXO data collected with a<br>3-D GPR system using beam forming tomography. We provide a brief summary the<br>beam tomography concept for discriminating based on data<br>provided by the EPFL\LAMI\DeTec project Lausanne. Using this technique efficacy<br>of producing high-resolution 3-D images synthetic array was<br>demonstrated. follow description new wide band linear system<br>that uses step-frequency...
This paper presents results of processing landmine and UXO data collected with a 3‐D GPR system using beam forming tomography. We provide brief summary the tomography concept for discriminating based on provided by EPFL\LAMI\DeTec project Lausanne. Using this technique efficacy producing high‐resolution images synthetic array was demonstrated. follow description new wide band linear that uses step‐frequency continuous waveform (SFCW). 3D‐GPR is capable operating in stand‐off mode; surveying...