Rebecca Hoyd
A5022597516- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Gut microbiota and health
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Advanced X-ray and CT Imaging
- Cutaneous Melanoma Detection and Management
- Mycobacterium research and diagnosis
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Frailty in Older Adults
- Cancer-related molecular mechanisms research
- Colorectal Cancer Screening and Detection
- Molecular Biology Techniques and Applications
- Single-cell and spatial transcriptomics
- Metabolomics and Mass Spectrometry Studies
- Nutrition and Health in Aging
- Head and Neck Cancer Studies
- Cardiac Imaging and Diagnostics
- IL-33, ST2, and ILC Pathways
The Ohio State University
2019-2025
Columbus Oncology and Hematology Associates
2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2021-2024
The Ohio State University Wexner Medical Center
2021-2024
Rigshospitalet
2023
Abstract Neutrophils are increasingly implicated in chronic inflammation and metabolic disorders. Here, we show that visceral adipose tissue (VAT) from individuals with obesity contains more neutrophils than those without is associated a distinct bacterial community. Exploring the mechanism, gavaged microbiome-depleted mice stool patients during high-fat or normal diet administration. Only receiving subjects enrichment of VAT neutrophils, suggesting donor microbiome recipient determine...
Abstract Background The microbiome has been shown to affect the response Immune Checkpoint Inhibitors (ICIs) in a small number of cancers and preclinical models. Here, we sought broadly survey identify those which may play prognostic role using retrospective analyses patients with advanced cancer treated ICIs. Methods We conducted analysis 690 who received ICI therapy for cancer. used literature review define causal model relationship between medications, microbiome, guide abstraction...
Abstract Tumor hypoxia has been shown to predict poor patient outcomes in several cancer types, partially because it reduces radiation’s ability kill cells. We hypothesized that some of the clinical effects could also be due its impact on tumor microbiome. Therefore, we examined RNA sequencing data from Oncology Research Information Exchange Network database patients with colorectal treated radiotherapy. identified microbial RNAs for each and related them hypoxic gene expression scores...
Emerging evidence supports the important role of tumor microbiome in oncogenesis, cancer immune phenotype, progression, and treatment outcomes many malignancies. In this study, we investigated metastatic melanoma its potential roles association with clinical outcomes, such as survival, patients disease treated checkpoint inhibitors (ICI). Baseline samples were collected from 71 before ICIs. Bulk RNA sequencing (RNA-seq) was conducted on formalin-fixed, paraffin-embedded fresh frozen samples....
Abstract Background We investigated the role of A2B-adenosine receptor in regulating immunosuppressive metabolic stress tumor microenvironment. Novel antagonist PBF-1129 was tested for antitumor activity mice and evaluated safety immunologic efficacy a phase I clinical trial patients with non-small cell lung cancer. Methods The antagonists their impact on immune microenvironment were lung, melanoma, colon, breast, epidermal growth factor receptor–inducible transgenic cancer models. Employing...
Abstract Evidence supports significant interactions among microbes, immune cells, and tumor cells in at least 10%–20% of human cancers, emphasizing the importance further investigating these complex relationships. However, implications significance tumor-related microbes remain largely unknown. Studies have demonstrated critical roles host cancer prevention treatment responses. Understanding between can drive diagnosis microbial therapeutics (bugs as drugs). Computational identification...
Abstract Cancer outcomes have improved with immune checkpoint inhibitor (ICI) treatment; however, less than half of tumors respond. Emerging data show that some responses to ICI depend on the host’s microbiome. Here, we explore a dietary intervention modify microbiome and determine response ICIs. Following pre-clinical studies showing benefit black raspberries, conducted human trial called BEWELL Study ( NCT04267874 ). The increased abundance pro-ICI-response microbes (PIRMs). In mouse...
Improved understanding of the factors that underlie immune checkpoint inhibitor (ICI) response and toxicity are needed as only half patients with metastatic melanoma respond, 10-40% experience immune-related adverse events (irAEs). Modifying gut microbiome could positively affect to ICIs reduce toxicities. Here, we sought determine if pre-treatment predicts ICI or in setting melanoma. Melanoma (n=88) over 18 years age, planning receive therapy enrolled a prospective observational cohort...
<p>Kruskal-Walis test results comparing the deconvolved immune cell compositions between hypoxic and normoxic tumors.</p>
<p>Numbers at risk for the association between survival and Fusobacterium canifelinum abundance in COADREAD tumors treated with radiation.</p>
<p>Demographic variables stratified by low and high hypoxia scores, showing no significant differences to be controlled for in the Cox proportional hazards model described Figure 1D.</p>
<p>Numbers at risk for the association between low and high hypoxia in COAD READ tumors (associated with Kaplan-Meier curve shown Figure 1D).</p>
<p>Boxplots showing the immune cell fractions for cells with significantly different expression in high and low hypoxia mouse samples at p-value <0.05. No differences remained significant after correction multiple hypothesis testing.</p>
<p>Log2 fold changes of annotated Cutibacterium genes between hypoxic and normoxic tumors in nude BALB/c mice.</p>
<p>Boxplot comparing Fusobacterium counts in low and high hypoxia 16s samples.</p>
<p>Differences in the immune cell populations, estimated by RNAseq, within high and low hypoxia mouse tumors, combining nude BALB/c mice.</p>
<p>Correlations between tumor microbes enriched in hypoxic tumors both mice and humans deconvolved immune cell abundances.</p>
<p>Differences in the tumor microbes low and high hypoxia mouse tumors.</p>
<p>Selected log2 fold change results for microbes found to be significantly enriched in hypoxic tumors both mice and human subjects.</p>
<p>Differences in the immune cell populations, estimated by RNAseq, within high and low hypoxia mouse tumors, separated strain.</p>
<p>Boxplots comparing immune fractions in low and high hypoxia groups the ORIEN radiation cohort, displaying cells with significantly different abundance an adjusted p-value <0.05.</p>
<p>Hypoxia scores by stage (A) or sex (B) for the ORIEN radiation-treated cohort.</p>