A5000551343- interferon and immune responses
- Ubiquitin and proteasome pathways
- Allergic Rhinitis and Sensitization
- Glioma Diagnosis and Treatment
- Food Allergy and Anaphylaxis Research
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Tuberous Sclerosis Complex Research
- Cerebrospinal fluid and hydrocephalus
- CRISPR and Genetic Engineering
- Single-cell and spatial transcriptomics
- Renal cell carcinoma treatment
- Respiratory and Cough-Related Research
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Renal and related cancers
- Herbal Medicine Research Studies
- Histiocytic Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Celiac Disease Research and Management
- Neurogenesis and neuroplasticity mechanisms
Cornell University
2019-2024
Weill Cornell Medicine
2022-2024
New York Genome Center
2024
New York University
2024
Neurological Surgery
2019-2024
University of Wisconsin–Madison
2020-2023
University of Wisconsin Carbone Cancer Center
2020-2023
Immune Tolerance Network
2020-2023
Johnson University
2020-2023
Rutgers, The State University of New Jersey
2020-2023
Recent work has highlighted the tumor microenvironment as a central player in cancer. In particular, interactions between and immune cells may help drive development of brain tumors such glioblastoma multiforme (GBM). Despite significant research into molecular classification glioblastoma, few studies have characterized comprehensive manner infiltrate situ within different GBM subtypes.In this study, we use an unbiased, automated immunohistochemistry-based approach to determine phenotype...
Renal angiomyolipoma is a kidney tumor in the perivascular epithelioid (PEComa) family that common patients with Tuberous Sclerosis Complex (TSC) and Lymphangioleiomyomatosis (LAM) but occurs rarely sporadically. Though histologically benign, renal can cause life-threatening hemorrhage failure. Both LAM have mutations TSC2 or TSC1. However, frequency contribution of other somatic events development unknown. We performed whole exome sequencing 32 resected samples (n = 30 angiomyolipoma, n 2...
Rationale Nasal allergen provocations may be useful in investigating the pathophysiology of allergic rhinitis and effects treatments. Objective To use grass pollen nasal challenge (NAC) to investigate immunotherapy a cross-sectional study. Methods We studied cutaneous responses untreated subjects with seasonal grass-pollen (n = 14) compared immunotherapy-treated allergics 14), plus nonatopic control group 14). Volunteers underwent standardized NAC 2000 biological units timothy (equivalent...
Abstract Taxanes remain one of the most effective medical treatments for breast cancer. Clinical trials have coupled taxanes with immune checkpoint inhibitors in patients triple-negative cancer (TNBC) promising results. However, mechanism linking to activation is unclear. To determine if paclitaxel could elicit an antitumoral response, we sampled tumor tissues from TNBC receiving weekly (80 mg/m2) and found increased stromal tumor-infiltrating lymphocytes micronucleation over baseline three...
Training on complements in English, German and Mandarin has been reported to trigger improvements both Theory of Mind (ToM), with typically developing (TD) pre-schoolers the verge these skills (Hale & Tager-Flusberg, 2003; Lohmann Tomasello, Shuliang, Yanjie, Sabbagh, 2014). In current study, we build idea that increasing mastery complementation holds promise enhancing ToM, seek (i) replicate positive effects observed previous work for this effect French-speaking TD children, (ii) pilot...
Structural variants (SVs) are increasingly recognized as important contributors to oncogenesis through their effects on 3D genome folding. Recent advances in whole-genome sequencing have enabled large-scale profiling of SVs across diverse tumors, yet experimental characterization individual impact folding remains infeasible. Here, we leveraged a convolutional neural network, Akita, predict disruptions caused by somatic identified 61 tumor types from the Children's Brain Tumor Network...
Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help us to understand pathophysiology improve outcomes. Here, we report adult ablation autism spectrum disorder (ASD)-associated CHD8 in astrocytes attenuates via remodeling chromatin accessibility, changing gene expression. Conditional Chd8 deletion astrocytes, but not microglia, suppresses by impeding astrocyte proliferation...
Tuberous sclerosis complex (TSC) is characterized by tumor development in the brain, heart, kidney, and lungs. In TSC tumors, loss of TSC1/TSC2 protein leads to activation mTORC1 with downstream effects on anabolism cell growth. Because enhances mRNA transcription, we hypothesized that aberrant might confer TSC-null dependence transcriptional regulation. We demonstrate TSC1- or TSC2-null cells, contrast their wild-type counterparts, are sensitive pharmacological inhibition CDK7. Mechanistic...
Background: Brain tumors are the most common solid in children, and high-grade brain leading cause of cancer-related death among all childhood cancers. Tumor segmentation is essential for surgical planning, treatment radiomics studies, but manual time-consuming has high interoperator variability. This paper presents a deep learning-based method automated pediatric based on multi-parametric MRI. Methods: Multi-parametric MRI (MP-MRI) scans (T1, T1w-Gd, T2, FLAIR) 167 patients with de novo...
Abstract Chromosome instability (CIN) generates genetic and karyotypic diversity that is common in hematological malignancies. Low to moderate levels of CIN are well tolerated can promote cancer proliferation. However, high lethal. Thus, may serve both as a prognostic factor predict clinical outcome predictive biomarker. A retrospective study was performed evaluate acute myeloid leukemia (AML). mis‐segregation frequency correlated with bone marrow core biopsy specimens from 17 AML cases....
Summary Recent massively-parallel approaches to decipher gene regulatory circuits have focused on the discovery of either cis -regulatory elements (CREs) or trans -acting factors. Here, we develop a scalable approach that pairs - and CRISPR screens systematically dissect how key immune checkpoint PD-L1 is regulated. In human pancreatic ductal adenocarcinoma (PDAC) cells, tile locus using ∼25,000 perturbations in constitutive IFNγ-stimulated conditions. We discover 67 enhancer- repressor-like...
Abstract BACKGROUND ACNS1123 was a Phase 2 trial that evaluated the survival benefit of whole ventricular irradiation (WVI) instead craniospinal in children with localized CNS NGGCTs who achieved complete/partial radiographic response (CR/PR) to induction chemotherapy negative tumor markers (beta-HCG/AFP) serum and cerebrospinal fluid (CSF). Patients did not achieve CR/PR were considered inevaluable removed from study therapy post-induction. METHODS In unplanned, exploratory analyses, we...
Coronavirus disease 2019 (COVID-19) is an immunoinflammatory and hypercoagulable state that contributes to respiratory distress, multi-organ dysfunction, mortality. Dipyridamole, by increasing extracellular adenosine, has been postulated be protective for COVID-19 patients through its immunosuppressive, anti-inflammatory, anti-coagulant, vasodilatory, anti-viral actions. Likewise, low-dose aspirin also demonstrated effects patients. This study evaluated the effect of these two drugs...