A5078738286- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Eosinophilic Esophagitis
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Retinoids in leukemia and cellular processes
- Celiac Disease Research and Management
- Transgenic Plants and Applications
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Viral-associated cancers and disorders
- Respiratory viral infections research
- Chemical Reactions and Isotopes
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Diabetes and associated disorders
- Viral Infections and Immunology Research
- Drug-Induced Adverse Reactions
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
Université Paris Cité
2008-2024
Assistance Publique – Hôpitaux de Paris
2024
Benaroya Research Institute
2015-2022
Virginia Mason Medical Center
2017-2022
Cancer Research Institute of the Slovak Academy of Sciences
2018
Inserm
2004-2009
Hôpital Saint-Louis
2004-2008
Délégation Paris 7
2008
Institut Universitaire de France
2008
A unique T helper cell signature in allergic patients isolates the pathogenic cells and provides a target for disease intervention.
Recent evidence in cancer research, developed the notion that malignant tumors consist of different subpopulations cells, one them, known as stem being attributed many important properties such enhanced tumorigenicity, proliferation potential and profound multidrug resistance to chemotherapy. Several key cells markers were identified colon cancer. In our study we focused on aldehyde dehydrogenase type 1 (ALDH1) expression cancer-derived cell lines HT-29/eGFP, HCT-116/eGFP LS-180/eGFP, its...
The PALISADE study, an international, phase 3 trial of peanut oral immunotherapy (POIT) with AR101, resulted in desensitization children and adolescents who were highly allergic to peanut. An improved understanding the immune mechanism induced response food allergen would enable more informed effective therapeutic strategies. Our main purpose was examine immunological changes blood samples from a subset peanut-allergic individuals undergoing AR101.
Background. Monitoring of Epstein-Barr virus (EBV) reactivation after allogeneic hematopoietic stem-cell transplantation markedly improved with quantitative real-time polymerase chain reaction amplification EBV DNA and visualization EBV-specific CD8+ T cells peptide-human leukocyte antigen (HLA) class I tetramers. We decided to combine these methods evaluate posttransplant rituximab therapy. Methods. followed 56 patients treated an HLA-genoidentical sibling (n=32), HLA-matched unrelated...
Tcell—mediated immunity is essential for the control of cytomegalovirus (CMV) infections in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our aims were to identify patterns CMV specific immune responses associated with multiple or prolonged reactivations. We analyzed findings 116 recipients during course infection reactivation and latency. CD8+ T determined weekly, using HLA class I tetramers together extended phenotypic analyses. results confirmed that...
Understanding the peanut-specific CD4 T cell responses in peanut allergic subjects should provide new insights into development of innovative immunotherapies for treatment allergy. Although cells have a TH2 profile peanut-allergic subjects, immunogenicity different Ara h components eliciting specific and heterogeneity these h-reactive remains unclear. In this study, we investigated 1, 2, 3, 6, 8-specific (PA) sensitized non-peanut-allergic (sNPA), using CD154 up-regulation assay class II...
Abstract Background Characterising the clinical and immunological impact of daily cat exposure in cat‐allergic subjects with asthma who live cats (WC) those do not (WoC) may provide understanding drivers allergic response. Methods Clinical characteristics (skin prick test, spirometry, symptom assessments, markers) were compared between asthmatic WC ( n = 10) WoC 9). Results had greater use long‐acting beta agonists p < .05) high‐potency corticosteroids. No differences observed lung...
Allergen-reactive TH2A cells are identified as a pathogenic subpopulation in allergic inflammation. We hypothesized would confer susceptibility to the effects of epithelial cytokine IL-33 due selective expression receptor ST2. sought determine whether ST2 was unique and role modulating human allergen-specific T cell responses. recruited seasonal (pollen), perennial (dust mite), or food (peanut) individuals on basis clinical history serum IgE > 0.35 kU/L. CD4+ were tracked using CD154 assay...
Food allergies manifest in a wide array of clinical manifestation and treatment response. Identification the cellular molecular mechanisms driving these differences has potential to reveal drug targets biomarkers predict We performed multi-modal immune-monitoring assess peanut-specific CD4 T cell properties both non-allergic individuals peanut allergic patients undergoing Double Blind Placebo Control Challenge (DBPCFC) allergen-specific immunotherapy. Peanut CD4+ cells were tracked using...
Abstract Rationale We aimed to evaluate the impact of daily cat exposure in allergic asthmatics by both clinical symptom and immunological measures. Methods Twenty adults with history cat-induced asthma rhinitis, positive serum dander-specific IgE (sIgE&gt;0.35kU/L) Skin Prick Test (SPT) were enrolled at a 1:1 ratio according ownership. For comparison, extract- Fel d1- specific basophil sensitivity test (BST), sIgE, sIgG4 SPT measured on Day 1 28; ambulatory spirometry measures obtained...