A5076795570- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Psoriasis: Treatment and Pathogenesis
- melanin and skin pigmentation
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Sperm and Testicular Function
- T-cell and B-cell Immunology
- Genital Health and Disease
- Nonmelanoma Skin Cancer Studies
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Urologic and reproductive health conditions
- Chemokine receptors and signaling
- Xenotransplantation and immune response
- Virus-based gene therapy research
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- NF-κB Signaling Pathways
- Skin Protection and Aging
- Herpesvirus Infections and Treatments
- Cell Adhesion Molecules Research
- Contact Dermatitis and Allergies
Regeneron (United States)
2020-2024
Rockefeller University
2011-2019
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2015
Wenzhou Medical University
2015
Cornell University
2012
NYU Langone Health
2012
Population Council
2006-2007
Population Council
2006-2007
The timely restructuring of the blood–testis barrier (BTB) that facilitates migration preleptotene and leptotene spermatocytes from basal to adluminal compartment in seminiferous epithelium adult rat testes, which occurs at late stage VII through early VIII epithelial cycle, is a crucial cellular event spermatogenesis. However, regulation BTB dynamics biochemical level remains elusive. In this study, tumor necrosis factor α (TNFα), secretory product Sertoli germ cells was shown affect...
Vitiligo is a common skin disorder, characterized by progressive de-pigmentation due to the loss of cutaneous melanocytes. The exact cause melanocyte remains unclear, but large number observations have pointed important role cellular immunity in vitiligo pathogenesis.
BackgroundHyperactivity of the IL-23/IL-17 axis is central to plaque psoriasis pathogenesis. Secukinumab, a fully human mAb that selectively inhibits IL-17A, approved for treatment psoriasis, psoriatic arthritis, and ankylosing spondylitis. Secukinumab improves complete spectrum manifestations, with durable clinical responses beyond 5 years treatment. In feed-forward model chronicity, IL-17A has been hypothesized as key driver pathogenic gene expression by lesional keratinocytes, but in vivo...
<h3>Background</h3> Tofacitinib is an oral Janus kinase inhibitor being investigated for psoriasis. <h3>Objective</h3> We sought to elucidate the molecular mechanisms underlying clinical efficacy of tofacitinib in patients with <h3>Methods</h3> Twelve plaque psoriasis were randomized (3:1) receive 10 mg or placebo twice daily 12 weeks. Biopsy specimens taken from nonlesional (baseline) and lesional (baseline, days 1 3, weeks 1, 2, 4, 12) skin. examined psoriatic epidermal features...
Patients with epidermodysplasia verruciformis (EV) and biallelic null mutations of TMC6 (encoding EVER1) or TMC8 (EVER2) are selectively prone to disseminated skin lesions due keratinocyte-tropic human β-papillomaviruses (β-HPVs), which lack E5 E8. We describe EV patients homozygous for the CIB1 gene encoding calcium- integrin-binding protein-1 (CIB1). is strongly expressed in cultured keratinocytes controls but not those patients. forms a complex EVER1 EVER2, proteins EVER1- EVER2-deficient...
<h3>Importance</h3> Limited therapies are available in patients with inoperable locally advanced cutaneous squamous cell carcinoma (cSCC). <h3>Objective</h3> To determine the efficacy of programmed death 1 receptor (PD-1) inhibitors cSCC. <h3>Design, Setting, and Participants</h3> A single patient cSCC who declined surgery radiotherapy underwent treatment pembrolizumab, an anti–PD-1 antibody, at academic dermatologic section cancer center. The was followed up for clinical radiologic...
Rationale: Sensitization to Fel d 1 (Felis domesticus allergen 1) contributes persistent allergic rhinitis and asthma. Existing treatment options for cat allergy, including immunotherapy, are only moderately effective, immunotherapy has limited use because of safety concerns. Objectives: To explore the relationship among pharmacokinetic, clinical, immunological effects anti-Fel monoclonal antibodies (REGN1908-1909) in patients after treatment. Methods: Patients received REGN1908-1909 (n =...
The efficacy of an allergen-specific IgG cocktail to treat cat allergy suggests that may be a major protective mechanism elicited by allergen immunotherapy.Extending these findings, we tested Bet v 1-specific antibody in birch-allergic subjects.This was phase 1, randomized, double-blind, study with 2 parts. Part A administered ascending doses the REGN5713/14/15 (150-900 mg) 32 healthy adults. B single subcutaneous 900-mg dose or placebo 64 subjects. Total nasal symptom score response...
Abstract Background Nasal epithelial cells are important regulators of barrier function and immune signaling; however, in allergic rhinitis (AR) these functions can be disrupted by inflammatory mediators. We aimed to better discern AR disease mechanisms using transcriptome data from nasal brushing samples individuals with without AR. Methods Data were drawn a feasibility study Timothy grass clinical trial evaluating 16 weeks treatment the following: dupilumab, monoclonal antibody that binds...
Immune suppressed organ transplant recipients suffer increased morbidity and mortality from primary cutaneous SCC. We studied tumor microenvironment in transplant-associated SCC (TSCC), immune-competent normal skin by IHC, IF RT-PCR on surgical discard. determined T cell polarization TSCC intracellular cytokine staining of crawl outs human explants. the effects IL-22, an inducer keratinocyte proliferation, proliferation vitro. are both associated with significantly higher numbers CD3+ CD8+...
Background: Subcutaneous immunotherapy (SCIT) has been proven as an effective therapy against some allergens for seasonal allergic rhinitis (SAR) patients unresponsive to intranasal corticosteroids and/or antihistamines but carries risk of systemic reactions. Dupilumab blocks the shared receptor component interleukin-4 and interleukin-13, key central drivers type 2 inflammation in multiple diseases. Objective: To evaluate efficacy safety SCIT+dupilumab vs SCIT alone. Methods: This phase 2a,...
BackgroundThe dominant allergen in cat dander, Felis domesticus 1 (Fel d 1), is a persistent trigger for allergic rhinitis and asthma symptoms.ObjectiveWe evaluated the efficacy of Fel monoclonal antibodies (REGN1908/1909) preventing allergen–induced early asthmatic responses (EARs) cat-allergic patients with mild asthma.MethodsPatients were randomized to single-dose REGN1908/1909 600 mg (n = 29) or placebo 27). The FEV1 was measured up 4 hours environmental exposure unit 85 days after...
Abstract Keloids are benign fibroproliferative tumors more frequently found among African Americans. Until now, keloid etiopathogenesis is not fully understood. To characterize keloids in Americans, we performed transcriptional profiling of biopsies from large chronic keloids, adjacent non‐lesional (NL) skin (n=3) and a newly formed lesion using Affymetrix HGU133 2.0 plus arrays. Quantitative RT‐PCR (qRT‐PCR) immunohistochemistry (IHC) staining were to confirm increased expression relevant...
In adult rat testes, blood–testis barrier (BTB) restructuring facilitates the migration of preleptotene spermatocytes from basal to adluminal compartment that occurs at stage VIII epithelial cycle. Structural proteins BTB must utilize an efficient mechanism (e.g. endocytosis) facilitate its transient ‘opening’. Dynamin II, a large GTPase known be involved in endocytosis, was shown product Sertoli and germ cells testis. It also localized BTB, as well apical ectoplasmic specialization (apical...
To characterize the presence of CD200 and receptor (CD200R) in human cutaneous squamous cell carcinoma (SCC) microenvironment to define a possible role for axis immune evasion by SCC.Gene expression SCC vs normal skin was studied. Laser capture microdissection used determine differential actinic keratosis situ invasive SCC. Immunofluorescence microscopy CD200R on macrophages, myeloid dendritic cells, natural killer T cells skin. The effects supernatant induction blood endothelial also...
Palmoplantar pustular psoriasis (PPPP) and non‒pustular palmoplantar (NPPP) are localized, debilitating forms of psoriasis. The inflammatory circuits involved in PPPP NPPP not well-understood. To compare the cellular immunological features that differentiate NPPP, skin biopsies were collected from a total 30 participants with PPPP, vulgaris (PV) 10 healthy participants. A subset consented to second biopsy after 3 additional weeks off medication. Histologic staining lesional nonlesional...
// Hanna Ning 1,* , Hiroshi Mitsui Claire Q.F. Wang 1 Mayte Suárez-Fariñas 1,2 Juana Gonzalez Kejal R. Shah 3 Jie Chen 4 Israel Coats Diane Felsen John A. Carucci 5 and James G. Krueger Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 2 Center Clinical Translational Science, USA Texas Dermatology Associates, Baylor University Medical Center, Dallas, TX Institute Pediatric Urology, Department of Weill Cornell College, Ronald O. Perelman York Langone * These...
Abstract REGN1908‐1909, a 1:1 cocktail of two fully human IgG 4 monoclonal antibodies (mAbs), REGN1908 and REGN1909, is being evaluated for treatment cat allergy. Both REGN1909 bind to the dominant allergen, Fel d 1. Adults with allergy confirmed by skin prick test (SPT) were randomized single subcutaneous administration placebo ( n = 6) or REGN1908‐1909 at doses 150 6), 300 600 mg 6). Blood samples taken prespecified time points pharmacokinetic (PK) analysis exploratory evaluation...